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Antinociceptive effect and GC/MS analysis of Rosmarinus officinalis L. essential oil from its aerial parts.
Planta Med. 2009 Apr; 75(5):508-11.PM

Abstract

The rationale of this investigation was to examine the antinociceptive properties of the essential oil obtained from Rosmarinus officinalis aerial parts, using a rat model of arthritic pain. The essential oil (100, 300 and 600 mg/kg, I. P.) produced a dose-dependent antinociceptive effect, manifested as a significant reduction in the dysfunction in the pain-induced functional impairment model in the rat (PIFIR model), mainly at high doses. Chemical constituents of the essential oil were further analyzed by gas chromatography-mass spectrometry (GC/MS). The major compounds in the essential oil were alpha-pinene (14.10 %), camphene (11.47 %), beta-pinene (12.02 %), myrcene (3.31 %), alpha-phellandrene (7.87 %), eucalyptol (8.58 %), 2-bornanone (3.42 %), camphor (8.75 %), isoborneol (3.48 %), borneol (4.85 %) and borneol acetate (6.49 %). The antinociceptive effects of R. officinalis essential oil were tested in combination with 0.12 mg/kg WAY100635, s. c. (an antagonist of 5-HT(1A) receptors) or 1 mg/kg naloxone, i. p. (an antagonist of endogenous opioids receptors), demonstrating in both cases an inhibition of the antinociceptive response. This study suggests an involvement, at least in part, of the serotonergic system via 5-HT(1A) receptors and endogenous opioids in the antinociceptive effect of R. officinalis essential oil in the PIFIR model.

Authors+Show Affiliations

Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México, D. F., México.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19184968

Citation

Martínez, Ana L., et al. "Antinociceptive Effect and GC/MS Analysis of Rosmarinus Officinalis L. Essential Oil From Its Aerial Parts." Planta Medica, vol. 75, no. 5, 2009, pp. 508-11.
Martínez AL, González-Trujano ME, Pellicer F, et al. Antinociceptive effect and GC/MS analysis of Rosmarinus officinalis L. essential oil from its aerial parts. Planta Med. 2009;75(5):508-11.
Martínez, A. L., González-Trujano, M. E., Pellicer, F., López-Muñoz, F. J., & Navarrete, A. (2009). Antinociceptive effect and GC/MS analysis of Rosmarinus officinalis L. essential oil from its aerial parts. Planta Medica, 75(5), 508-11. https://doi.org/10.1055/s-0029-1185319
Martínez AL, et al. Antinociceptive Effect and GC/MS Analysis of Rosmarinus Officinalis L. Essential Oil From Its Aerial Parts. Planta Med. 2009;75(5):508-11. PubMed PMID: 19184968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive effect and GC/MS analysis of Rosmarinus officinalis L. essential oil from its aerial parts. AU - Martínez,Ana L, AU - González-Trujano,Maria Eva, AU - Pellicer,Francisco, AU - López-Muñoz,Francisco J, AU - Navarrete,Andrés, Y1 - 2009/01/30/ PY - 2009/2/3/entrez PY - 2009/2/3/pubmed PY - 2009/9/16/medline SP - 508 EP - 11 JF - Planta medica JO - Planta Med. VL - 75 IS - 5 N2 - The rationale of this investigation was to examine the antinociceptive properties of the essential oil obtained from Rosmarinus officinalis aerial parts, using a rat model of arthritic pain. The essential oil (100, 300 and 600 mg/kg, I. P.) produced a dose-dependent antinociceptive effect, manifested as a significant reduction in the dysfunction in the pain-induced functional impairment model in the rat (PIFIR model), mainly at high doses. Chemical constituents of the essential oil were further analyzed by gas chromatography-mass spectrometry (GC/MS). The major compounds in the essential oil were alpha-pinene (14.10 %), camphene (11.47 %), beta-pinene (12.02 %), myrcene (3.31 %), alpha-phellandrene (7.87 %), eucalyptol (8.58 %), 2-bornanone (3.42 %), camphor (8.75 %), isoborneol (3.48 %), borneol (4.85 %) and borneol acetate (6.49 %). The antinociceptive effects of R. officinalis essential oil were tested in combination with 0.12 mg/kg WAY100635, s. c. (an antagonist of 5-HT(1A) receptors) or 1 mg/kg naloxone, i. p. (an antagonist of endogenous opioids receptors), demonstrating in both cases an inhibition of the antinociceptive response. This study suggests an involvement, at least in part, of the serotonergic system via 5-HT(1A) receptors and endogenous opioids in the antinociceptive effect of R. officinalis essential oil in the PIFIR model. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/19184968/Antinociceptive_effect_and_GC/MS_analysis_of_Rosmarinus_officinalis_L__essential_oil_from_its_aerial_parts_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0029-1185319 DB - PRIME DP - Unbound Medicine ER -