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Hyperbaric oxygen preconditioning reduces ischemia-reperfusion injury by inhibition of apoptosis via mitochondrial pathway in rat brain.
Neuroscience. 2009 Apr 10; 159(4):1309-15.N

Abstract

This study examined the hypothesis that apoptotic inhibition via mitochondrial pathway was involved in hyperbaric oxygen preconditioning (HBO-PC)-induced neuroprotection on ischemia-reperfusion injury in rat brain. Male Sprague-Dawley rats (250 approximately 280 g, n=144) were divided into control, middle cerebral artery occlusion (MCAO) for 90 min, and HBO-PC plus MCAO groups. HBO-PC was conducted four times by giving 100% oxygen at 2.5 atm absolute (ATA), for 1 h at 12 h intervals for 2 days. At 24 h after the last HBO-PC, MCAO was performed and at 24 h after MCAO, neurological function, brain water content, infarct volume, and cell death were evaluated. Enzymatic activity of capase-3 and -9, and expression of cytochrome c, Bcl-2 and Bax proteins were performed in the samples from hippocampus, ischemic penumbra and core of the brain cortex, respectively. HBO-PC reduced brain edema, decreased infarction volume, and improved neurological recovery. HBO-PC reduced cytoplasm cytochrome c levels, decreased caspase enzyme activity, upregulated the ratio of Bcl-2 and Bax expression, and abated the apoptosis of ischemic tissue. HBO-PC protects brain tissues from ischemia-reperfusion injury by suppressing mitochondrial apoptotic pathways.

Authors+Show Affiliations

Department of Neurology, Changhai Hospital, 168 Changhai Road, Shanghai, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19185051

Citation

Li, J-S, et al. "Hyperbaric Oxygen Preconditioning Reduces Ischemia-reperfusion Injury By Inhibition of Apoptosis Via Mitochondrial Pathway in Rat Brain." Neuroscience, vol. 159, no. 4, 2009, pp. 1309-15.
Li JS, Zhang W, Kang ZM, et al. Hyperbaric oxygen preconditioning reduces ischemia-reperfusion injury by inhibition of apoptosis via mitochondrial pathway in rat brain. Neuroscience. 2009;159(4):1309-15.
Li, J. S., Zhang, W., Kang, Z. M., Ding, S. J., Liu, W. W., Zhang, J. H., Guan, Y. T., & Sun, X. J. (2009). Hyperbaric oxygen preconditioning reduces ischemia-reperfusion injury by inhibition of apoptosis via mitochondrial pathway in rat brain. Neuroscience, 159(4), 1309-15. https://doi.org/10.1016/j.neuroscience.2009.01.011
Li JS, et al. Hyperbaric Oxygen Preconditioning Reduces Ischemia-reperfusion Injury By Inhibition of Apoptosis Via Mitochondrial Pathway in Rat Brain. Neuroscience. 2009 Apr 10;159(4):1309-15. PubMed PMID: 19185051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperbaric oxygen preconditioning reduces ischemia-reperfusion injury by inhibition of apoptosis via mitochondrial pathway in rat brain. AU - Li,J-S, AU - Zhang,W, AU - Kang,Z-M, AU - Ding,S-J, AU - Liu,W-W, AU - Zhang,J H, AU - Guan,Y-T, AU - Sun,X-J, Y1 - 2009/01/13/ PY - 2008/10/10/received PY - 2009/01/01/revised PY - 2009/01/05/accepted PY - 2009/2/3/entrez PY - 2009/2/3/pubmed PY - 2009/8/21/medline SP - 1309 EP - 15 JF - Neuroscience JO - Neuroscience VL - 159 IS - 4 N2 - This study examined the hypothesis that apoptotic inhibition via mitochondrial pathway was involved in hyperbaric oxygen preconditioning (HBO-PC)-induced neuroprotection on ischemia-reperfusion injury in rat brain. Male Sprague-Dawley rats (250 approximately 280 g, n=144) were divided into control, middle cerebral artery occlusion (MCAO) for 90 min, and HBO-PC plus MCAO groups. HBO-PC was conducted four times by giving 100% oxygen at 2.5 atm absolute (ATA), for 1 h at 12 h intervals for 2 days. At 24 h after the last HBO-PC, MCAO was performed and at 24 h after MCAO, neurological function, brain water content, infarct volume, and cell death were evaluated. Enzymatic activity of capase-3 and -9, and expression of cytochrome c, Bcl-2 and Bax proteins were performed in the samples from hippocampus, ischemic penumbra and core of the brain cortex, respectively. HBO-PC reduced brain edema, decreased infarction volume, and improved neurological recovery. HBO-PC reduced cytoplasm cytochrome c levels, decreased caspase enzyme activity, upregulated the ratio of Bcl-2 and Bax expression, and abated the apoptosis of ischemic tissue. HBO-PC protects brain tissues from ischemia-reperfusion injury by suppressing mitochondrial apoptotic pathways. SN - 1873-7544 UR - https://www.unboundmedicine.com/medline/citation/19185051/Hyperbaric_oxygen_preconditioning_reduces_ischemia_reperfusion_injury_by_inhibition_of_apoptosis_via_mitochondrial_pathway_in_rat_brain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(09)00009-8 DB - PRIME DP - Unbound Medicine ER -