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VEGF protects motor neurons against excitotoxicity by upregulation of GluR2.
Neurobiol Aging. 2010 Dec; 31(12):2185-91.NA

Abstract

Influx of Ca(2+) ions through the α-amino-3-hydroxy-5-methylisoxazole propionic acid (AMPA) receptors is toxic to neurons and contributes to motor neuron degeneration observed in amyotrophic lateral sclerosis (ALS). The Ca(2+) permeability of the AMPA receptor depends on its subunit composition. If the GluR2 subunit is present in the receptor complex, the AMPA receptor is impermeable to Ca(2+). In this study, we identified vascular endothelial growth factor-A (VEGF) as a GluR2 inducing molecule. Cultured motor neurons pretreated with VEGF displayed higher GluR2 levels. This resulted in AMPA receptor currents with a low relative Ca(2+) permeability and in motor neurons that were less vulnerable to AMPA receptor-mediated excitotoxicity. This effect of VEGF was mediated through the VEGFR2 present on the motor neurons and was due to stimulation of GluR2 transcription. Intracerebroventricular treatment with VEGF similarly induced GluR2 expression in the ventral spinal cord of rats and this mechanism contributes to the protective effect of VEGF on motor neurons.

Authors+Show Affiliations

Laboratory of Neurobiology, Experimental Neurology, K.U. Leuven, Leuven, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19185395

Citation

Bogaert, Elke, et al. "VEGF Protects Motor Neurons Against Excitotoxicity By Upregulation of GluR2." Neurobiology of Aging, vol. 31, no. 12, 2010, pp. 2185-91.
Bogaert E, Van Damme P, Poesen K, et al. VEGF protects motor neurons against excitotoxicity by upregulation of GluR2. Neurobiol Aging. 2010;31(12):2185-91.
Bogaert, E., Van Damme, P., Poesen, K., Dhondt, J., Hersmus, N., Kiraly, D., Scheveneels, W., Robberecht, W., & Van Den Bosch, L. (2010). VEGF protects motor neurons against excitotoxicity by upregulation of GluR2. Neurobiology of Aging, 31(12), 2185-91. https://doi.org/10.1016/j.neurobiolaging.2008.12.007
Bogaert E, et al. VEGF Protects Motor Neurons Against Excitotoxicity By Upregulation of GluR2. Neurobiol Aging. 2010;31(12):2185-91. PubMed PMID: 19185395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - VEGF protects motor neurons against excitotoxicity by upregulation of GluR2. AU - Bogaert,Elke, AU - Van Damme,Philip, AU - Poesen,Koen, AU - Dhondt,Joke, AU - Hersmus,Nicole, AU - Kiraly,Dora, AU - Scheveneels,Wendy, AU - Robberecht,Wim, AU - Van Den Bosch,Ludo, Y1 - 2009/01/29/ PY - 2008/09/15/received PY - 2008/11/27/revised PY - 2008/12/02/accepted PY - 2009/2/3/entrez PY - 2009/2/3/pubmed PY - 2011/8/30/medline SP - 2185 EP - 91 JF - Neurobiology of aging JO - Neurobiol Aging VL - 31 IS - 12 N2 - Influx of Ca(2+) ions through the α-amino-3-hydroxy-5-methylisoxazole propionic acid (AMPA) receptors is toxic to neurons and contributes to motor neuron degeneration observed in amyotrophic lateral sclerosis (ALS). The Ca(2+) permeability of the AMPA receptor depends on its subunit composition. If the GluR2 subunit is present in the receptor complex, the AMPA receptor is impermeable to Ca(2+). In this study, we identified vascular endothelial growth factor-A (VEGF) as a GluR2 inducing molecule. Cultured motor neurons pretreated with VEGF displayed higher GluR2 levels. This resulted in AMPA receptor currents with a low relative Ca(2+) permeability and in motor neurons that were less vulnerable to AMPA receptor-mediated excitotoxicity. This effect of VEGF was mediated through the VEGFR2 present on the motor neurons and was due to stimulation of GluR2 transcription. Intracerebroventricular treatment with VEGF similarly induced GluR2 expression in the ventral spinal cord of rats and this mechanism contributes to the protective effect of VEGF on motor neurons. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/19185395/VEGF_protects_motor_neurons_against_excitotoxicity_by_upregulation_of_GluR2_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(08)00418-1 DB - PRIME DP - Unbound Medicine ER -