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Mannose binding lectin gene polymorphisms and associated auto-immune diseases in type 1 diabetes Brazilian patients.
Clin Immunol 2009; 131(2):254-9CI

Abstract

In our study we investigated the possible role of MBL2 functional single nucleotide polymorphisms (SNPs) in the augmented susceptibility to develop other autoimmune diseases in presence of type 1 diabetes (T1D) in a group of Brazilian patients. Patients were stratified for the presence of autoimmune diseases known to be associated with T1D, such as autoimmune thyroid disease (AITD) and celiac disease (CD), and compared with healthy controls (HC). Our findings suggest that MBL2 functional SNPs are more closely related to AITD than to T1D, being MBL2 SNPs frequencies in T1D patients not affected by AITD comparable to the HC ones, while significantly different between AITD patients and patients not affected by the disease. Thus, the association between MBL2 polymorphisms and T1D that we previously reported, seems to result from the stronger association of MBL2 SNPs with another autoimmune disease, the AITD, frequently associated with T1D.

Authors+Show Affiliations

Pediatric Endocrinology Unit of Clinical Hospital, Federal University of Pernambuco, Pernambuco, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19185543

Citation

Araujo, Jacqueline, et al. "Mannose Binding Lectin Gene Polymorphisms and Associated Auto-immune Diseases in Type 1 Diabetes Brazilian Patients." Clinical Immunology (Orlando, Fla.), vol. 131, no. 2, 2009, pp. 254-9.
Araujo J, Segat L, Guimarães RL, et al. Mannose binding lectin gene polymorphisms and associated auto-immune diseases in type 1 diabetes Brazilian patients. Clin Immunol. 2009;131(2):254-9.
Araujo, J., Segat, L., Guimarães, R. L., Brandão, L. A., Souza, P. E., Santos, S., ... Crovella, S. (2009). Mannose binding lectin gene polymorphisms and associated auto-immune diseases in type 1 diabetes Brazilian patients. Clinical Immunology (Orlando, Fla.), 131(2), pp. 254-9. doi:10.1016/j.clim.2008.12.010.
Araujo J, et al. Mannose Binding Lectin Gene Polymorphisms and Associated Auto-immune Diseases in Type 1 Diabetes Brazilian Patients. Clin Immunol. 2009;131(2):254-9. PubMed PMID: 19185543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mannose binding lectin gene polymorphisms and associated auto-immune diseases in type 1 diabetes Brazilian patients. AU - Araujo,Jacqueline, AU - Segat,Ludovica, AU - Guimarães,Rafael L, AU - Brandão,Lucas A C, AU - Souza,Paulo E R, AU - Santos,Sérgio, AU - Soares,Thereza S, AU - Falcão,Elcy A, AU - Rodrigues,Fernanda, AU - Carvalho,Ronaldo,Jr AU - de Lima-Filho,José Luiz, AU - Arraes,Luiz Claudio, AU - Crovella,Sergio, Y1 - 2009/01/29/ PY - 2008/08/20/received PY - 2008/12/24/revised PY - 2008/12/28/accepted PY - 2009/2/3/entrez PY - 2009/2/3/pubmed PY - 2009/5/16/medline SP - 254 EP - 9 JF - Clinical immunology (Orlando, Fla.) JO - Clin. Immunol. VL - 131 IS - 2 N2 - In our study we investigated the possible role of MBL2 functional single nucleotide polymorphisms (SNPs) in the augmented susceptibility to develop other autoimmune diseases in presence of type 1 diabetes (T1D) in a group of Brazilian patients. Patients were stratified for the presence of autoimmune diseases known to be associated with T1D, such as autoimmune thyroid disease (AITD) and celiac disease (CD), and compared with healthy controls (HC). Our findings suggest that MBL2 functional SNPs are more closely related to AITD than to T1D, being MBL2 SNPs frequencies in T1D patients not affected by AITD comparable to the HC ones, while significantly different between AITD patients and patients not affected by the disease. Thus, the association between MBL2 polymorphisms and T1D that we previously reported, seems to result from the stronger association of MBL2 SNPs with another autoimmune disease, the AITD, frequently associated with T1D. SN - 1521-7035 UR - https://www.unboundmedicine.com/medline/citation/19185543/Mannose_binding_lectin_gene_polymorphisms_and_associated_auto_immune_diseases_in_type_1_diabetes_Brazilian_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6616(09)00002-3 DB - PRIME DP - Unbound Medicine ER -