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Hypercaloric diets differing in fat composition have similar effects on serum leptin and weight gain in female subjects with anorexia nervosa.
Nutr Res. 2009 Jan; 29(1):1-7.NR

Abstract

Weight regain in subjects with anorexia nervosa is associated with an increase in serum leptin concentrations that is hypothesized to impair full weight restoration. As diets rich in n-3 polyunsaturated fatty acids (PUFA) have been described to lower serum leptin concentrations, we tested the hypothesis that consumption of a hypercaloric diet rich in n-3 PUFA is associated with an attenuated increase in serum leptin and a higher efficiency of body weight gain in subjects with anorexia nervosa. Twenty-five female subjects with anorexia nervosa were enrolled into this controlled dietary intervention study. Four subjects discontinued therapy or participation in the study prematurely, and six were excluded. 15 subjects completed the study. Subjects consumed hypercaloric diets rich in either saturated fatty acids (SFA, n = 8) or n-3 PUFA (n = 7) for 5 weeks. Primary endpoints were the change in serum leptin concentrations and body weight gain relative to energy consumed. Serum leptin concentrations increased distinctly throughout the study (P < .001), and to a similar extend in both groups [+2.9 (SD 2.4) vs. +2.8 (SD 3.4) ng/mL in the SFA- and n-3 PUFA group, respectively; P = .487]. The efficiency of body weight gain also did not differ significantly between groups, with a body weight gain of 63.1 (SD 12.4) vs. 79.2 (SD 26.0) g per 4.2 MJ (1000 kcal) consumed in the SFA- and n-3 PUFA group, respectively (P = .132). Hypercaloric diets rich in either SFA or n-3 PUFA do not differ in their effects on serum leptin concentrations and the efficiency of body weight gain in female subjects with anorexia nervosa.

Authors+Show Affiliations

Christoph-Dornier-Clinic for Psychotherapy, 48143 Münster, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19185771

Citation

Mauler, Birgit, et al. "Hypercaloric Diets Differing in Fat Composition Have Similar Effects On Serum Leptin and Weight Gain in Female Subjects With Anorexia Nervosa." Nutrition Research (New York, N.Y.), vol. 29, no. 1, 2009, pp. 1-7.
Mauler B, Dubben S, Pawelzik M, et al. Hypercaloric diets differing in fat composition have similar effects on serum leptin and weight gain in female subjects with anorexia nervosa. Nutr Res. 2009;29(1):1-7.
Mauler, B., Dubben, S., Pawelzik, M., Pawelzik, D., Weigle, D. S., & Kratz, M. (2009). Hypercaloric diets differing in fat composition have similar effects on serum leptin and weight gain in female subjects with anorexia nervosa. Nutrition Research (New York, N.Y.), 29(1), 1-7. https://doi.org/10.1016/j.nutres.2008.12.001
Mauler B, et al. Hypercaloric Diets Differing in Fat Composition Have Similar Effects On Serum Leptin and Weight Gain in Female Subjects With Anorexia Nervosa. Nutr Res. 2009;29(1):1-7. PubMed PMID: 19185771.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypercaloric diets differing in fat composition have similar effects on serum leptin and weight gain in female subjects with anorexia nervosa. AU - Mauler,Birgit, AU - Dubben,Svenja, AU - Pawelzik,Markus, AU - Pawelzik,Dorothea, AU - Weigle,David S, AU - Kratz,Mario, PY - 2008/09/26/received PY - 2008/12/10/revised PY - 2008/12/11/accepted PY - 2009/2/3/entrez PY - 2009/2/3/pubmed PY - 2009/3/28/medline SP - 1 EP - 7 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 29 IS - 1 N2 - Weight regain in subjects with anorexia nervosa is associated with an increase in serum leptin concentrations that is hypothesized to impair full weight restoration. As diets rich in n-3 polyunsaturated fatty acids (PUFA) have been described to lower serum leptin concentrations, we tested the hypothesis that consumption of a hypercaloric diet rich in n-3 PUFA is associated with an attenuated increase in serum leptin and a higher efficiency of body weight gain in subjects with anorexia nervosa. Twenty-five female subjects with anorexia nervosa were enrolled into this controlled dietary intervention study. Four subjects discontinued therapy or participation in the study prematurely, and six were excluded. 15 subjects completed the study. Subjects consumed hypercaloric diets rich in either saturated fatty acids (SFA, n = 8) or n-3 PUFA (n = 7) for 5 weeks. Primary endpoints were the change in serum leptin concentrations and body weight gain relative to energy consumed. Serum leptin concentrations increased distinctly throughout the study (P < .001), and to a similar extend in both groups [+2.9 (SD 2.4) vs. +2.8 (SD 3.4) ng/mL in the SFA- and n-3 PUFA group, respectively; P = .487]. The efficiency of body weight gain also did not differ significantly between groups, with a body weight gain of 63.1 (SD 12.4) vs. 79.2 (SD 26.0) g per 4.2 MJ (1000 kcal) consumed in the SFA- and n-3 PUFA group, respectively (P = .132). Hypercaloric diets rich in either SFA or n-3 PUFA do not differ in their effects on serum leptin concentrations and the efficiency of body weight gain in female subjects with anorexia nervosa. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/19185771/Hypercaloric_diets_differing_in_fat_composition_have_similar_effects_on_serum_leptin_and_weight_gain_in_female_subjects_with_anorexia_nervosa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(08)00257-1 DB - PRIME DP - Unbound Medicine ER -