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Retropubic, laparoscopic, and robot-assisted radical prostatectomy: a systematic review and cumulative analysis of comparative studies.
Eur Urol. 2009 May; 55(5):1037-63.EU

Abstract

CONTEXT

Despite the wide diffusion of laparoscopic radical prostatectomy (LRP) and robot-assisted laparoscopic radical prostatectomy (RALP), only few studies comparing the results of these techniques with the retropubic radical prostatectomy (RRP) are currently available.

OBJECTIVE

To evaluate the perioperative, functional, and oncologic results in the comparative studies evaluating RRP, LRP, and RALP.

EVIDENCE ACQUISITION

A systematic review of the literature was performed in January 2008, searching Medline, Embase, and Web of Science databases. A "free-text" protocol using the term radical prostatectomy was applied. Some 4000 records were retrieved from the Medline database; 2265 records were retrieved from the Embase database;, and 4219 records were retrieved from the Web of Science database. Three of the authors reviewed the records to identify comparative studies. A cumulative analysis was conducted using Review Manager software v.4.2 (Cochrane Collaboration, Oxford, UK).

EVIDENCE SYNTHESIS

Thirty-seven comparative studies were identified in the literature search, including a single, randomised, controlled trial. With regard to the perioperative outcome, LRP and RALP were more time consuming than RRP, especially in the initial steps of the learning curve, but blood loss, transfusion rates, catheterisation time, hospitalisation duration, and complication rates all favoured LRP. With regard to the functional results, LRP and RRP showed similar continence and potency rates. Similarly, no significant differences were identified between LRP and RALP, while a single, nonrandomised, prospective study suggested advantages in terms of both continence and potency recovery after RALP, compared with RRP. With regard to the oncologic outcome, LRP and RALP were associated with positive surgical margin rates similar to those of RRP.

CONCLUSIONS

The quality of the available comparative studies was not excellent. LRP and RALP are followed by significantly lower blood loss and transfusion rates, but the available data were not sufficient to prove the superiority of any surgical approach in terms of functional and oncologic outcomes. Further high-quality, prospective, multicentre, comparative studies are needed.

Authors+Show Affiliations

Department of Oncological and Surgical Sciences, Urology Clinic, University of Padua, Padua, Italy. vincenzo.ficarra@unipd.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Review
Systematic Review

Language

eng

PubMed ID

19185977

Citation

Ficarra, Vincenzo, et al. "Retropubic, Laparoscopic, and Robot-assisted Radical Prostatectomy: a Systematic Review and Cumulative Analysis of Comparative Studies." European Urology, vol. 55, no. 5, 2009, pp. 1037-63.
Ficarra V, Novara G, Artibani W, et al. Retropubic, laparoscopic, and robot-assisted radical prostatectomy: a systematic review and cumulative analysis of comparative studies. Eur Urol. 2009;55(5):1037-63.
Ficarra, V., Novara, G., Artibani, W., Cestari, A., Galfano, A., Graefen, M., Guazzoni, G., Guillonneau, B., Menon, M., Montorsi, F., Patel, V., Rassweiler, J., & Van Poppel, H. (2009). Retropubic, laparoscopic, and robot-assisted radical prostatectomy: a systematic review and cumulative analysis of comparative studies. European Urology, 55(5), 1037-63. https://doi.org/10.1016/j.eururo.2009.01.036
Ficarra V, et al. Retropubic, Laparoscopic, and Robot-assisted Radical Prostatectomy: a Systematic Review and Cumulative Analysis of Comparative Studies. Eur Urol. 2009;55(5):1037-63. PubMed PMID: 19185977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retropubic, laparoscopic, and robot-assisted radical prostatectomy: a systematic review and cumulative analysis of comparative studies. AU - Ficarra,Vincenzo, AU - Novara,Giacomo, AU - Artibani,Walter, AU - Cestari,Andrea, AU - Galfano,Antonio, AU - Graefen,Markus, AU - Guazzoni,Giorgio, AU - Guillonneau,Bertrand, AU - Menon,Mani, AU - Montorsi,Francesco, AU - Patel,Vipul, AU - Rassweiler,Jens, AU - Van Poppel,Hendrik, Y1 - 2009/01/25/ PY - 2008/12/11/received PY - 2009/01/16/accepted PY - 2009/2/3/entrez PY - 2009/2/3/pubmed PY - 2009/10/27/medline SP - 1037 EP - 63 JF - European urology JO - Eur. Urol. VL - 55 IS - 5 N2 - CONTEXT: Despite the wide diffusion of laparoscopic radical prostatectomy (LRP) and robot-assisted laparoscopic radical prostatectomy (RALP), only few studies comparing the results of these techniques with the retropubic radical prostatectomy (RRP) are currently available. OBJECTIVE: To evaluate the perioperative, functional, and oncologic results in the comparative studies evaluating RRP, LRP, and RALP. EVIDENCE ACQUISITION: A systematic review of the literature was performed in January 2008, searching Medline, Embase, and Web of Science databases. A "free-text" protocol using the term radical prostatectomy was applied. Some 4000 records were retrieved from the Medline database; 2265 records were retrieved from the Embase database;, and 4219 records were retrieved from the Web of Science database. Three of the authors reviewed the records to identify comparative studies. A cumulative analysis was conducted using Review Manager software v.4.2 (Cochrane Collaboration, Oxford, UK). EVIDENCE SYNTHESIS: Thirty-seven comparative studies were identified in the literature search, including a single, randomised, controlled trial. With regard to the perioperative outcome, LRP and RALP were more time consuming than RRP, especially in the initial steps of the learning curve, but blood loss, transfusion rates, catheterisation time, hospitalisation duration, and complication rates all favoured LRP. With regard to the functional results, LRP and RRP showed similar continence and potency rates. Similarly, no significant differences were identified between LRP and RALP, while a single, nonrandomised, prospective study suggested advantages in terms of both continence and potency recovery after RALP, compared with RRP. With regard to the oncologic outcome, LRP and RALP were associated with positive surgical margin rates similar to those of RRP. CONCLUSIONS: The quality of the available comparative studies was not excellent. LRP and RALP are followed by significantly lower blood loss and transfusion rates, but the available data were not sufficient to prove the superiority of any surgical approach in terms of functional and oncologic outcomes. Further high-quality, prospective, multicentre, comparative studies are needed. SN - 1873-7560 UR - https://www.unboundmedicine.com/medline/citation/19185977/Retropubic_laparoscopic_and_robot_assisted_radical_prostatectomy:_a_systematic_review_and_cumulative_analysis_of_comparative_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0302-2838(09)00049-9 DB - PRIME DP - Unbound Medicine ER -