Tags

Type your tag names separated by a space and hit enter

Inflammatory and oxidative stress biomarkers in allergic rhinitis: the effect of smoking.
Clin Exp Allergy. 2009 Mar; 39(3):345-53.CE

Abstract

BACKGROUND

Accumulating evidence confirms the presence of pan-airway inflammation in allergic rhinitis patients. Smoking is known to affect the asthmatic airway inflammation. However, no study has evaluated the impact of smoking on airway inflammation of allergic rhinitis patients.

OBJECTIVE

The aim of the present study was to evaluate the impact of smoking on inflammatory and oxidative stress biomarkers in patients with seasonal allergic rhinitis, using non-invasive methods for sample collection.

METHODS

Forty patients with seasonal allergic rhinitis (20 smokers and 20 non-smokers) and 30 healthy subjects (15 smokers and 15 non-smokers) were recruited for the study during pollen season. All subjects were submitted to measurement of the fraction of exhaled NO (FeNO), exhaled breath condensate (EBC) collection, nasal lavage collection, pre- and post- bronchodilation spirometry and metacholine bronchial challenge testing. pH, leukotriene B(4) (LTB(4)) and 8-isoprostane were determined in EBC and nasal lavage samples.

RESULTS

Patients with allergic rhinitis presented higher LTB(4) and 8-isoprostane levels in nasal lavage (P<0.0001 for both comparisons), with no significant differences between smokers and non-smokers. Patients with allergic rhinitis also presented higher LTB(4) levels and lower pH in EBC (P<0.001 and P=0.004, respectively), with prominent differences between smokers and non-smokers (P<0.0001 and P=0.003, for LTB(4) and pH, respectively). A significant correlation between nasal lavage and EBC LTB(4) values was observed (r(s)=0.313, P=0.048).

CONCLUSIONS

Patients with allergic rhinitis present increased LTB(4) and 8-isoprostane in their nasal cavity, however, with no significant differences between smokers and non-smokers. In contrast, smokers with allergic rhinitis present higher LTB(4) levels and lower pH in EBC, suggesting that these patients may be more susceptible to the deleterious effects of smoking, compared with non-smokers.

Authors+Show Affiliations

Respiratory Medicine Department, University of Thessaly Medical School, University Hospital of Larissa, Larissa, Greece. ktk@otenet.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19187324

Citation

Tanou, K, et al. "Inflammatory and Oxidative Stress Biomarkers in Allergic Rhinitis: the Effect of Smoking." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 39, no. 3, 2009, pp. 345-53.
Tanou K, Koutsokera A, Kiropoulos TS, et al. Inflammatory and oxidative stress biomarkers in allergic rhinitis: the effect of smoking. Clin Exp Allergy. 2009;39(3):345-53.
Tanou, K., Koutsokera, A., Kiropoulos, T. S., Maniati, M., Papaioannou, A. I., Georga, K., Zarogiannis, S., Gourgoulianis, K. I., & Kostikas, K. (2009). Inflammatory and oxidative stress biomarkers in allergic rhinitis: the effect of smoking. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 39(3), 345-53. https://doi.org/10.1111/j.1365-2222.2008.03149.x
Tanou K, et al. Inflammatory and Oxidative Stress Biomarkers in Allergic Rhinitis: the Effect of Smoking. Clin Exp Allergy. 2009;39(3):345-53. PubMed PMID: 19187324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inflammatory and oxidative stress biomarkers in allergic rhinitis: the effect of smoking. AU - Tanou,K, AU - Koutsokera,A, AU - Kiropoulos,T S, AU - Maniati,M, AU - Papaioannou,A I, AU - Georga,K, AU - Zarogiannis,S, AU - Gourgoulianis,K I, AU - Kostikas,K, PY - 2009/2/4/entrez PY - 2009/2/4/pubmed PY - 2009/3/31/medline SP - 345 EP - 53 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin Exp Allergy VL - 39 IS - 3 N2 - BACKGROUND: Accumulating evidence confirms the presence of pan-airway inflammation in allergic rhinitis patients. Smoking is known to affect the asthmatic airway inflammation. However, no study has evaluated the impact of smoking on airway inflammation of allergic rhinitis patients. OBJECTIVE: The aim of the present study was to evaluate the impact of smoking on inflammatory and oxidative stress biomarkers in patients with seasonal allergic rhinitis, using non-invasive methods for sample collection. METHODS: Forty patients with seasonal allergic rhinitis (20 smokers and 20 non-smokers) and 30 healthy subjects (15 smokers and 15 non-smokers) were recruited for the study during pollen season. All subjects were submitted to measurement of the fraction of exhaled NO (FeNO), exhaled breath condensate (EBC) collection, nasal lavage collection, pre- and post- bronchodilation spirometry and metacholine bronchial challenge testing. pH, leukotriene B(4) (LTB(4)) and 8-isoprostane were determined in EBC and nasal lavage samples. RESULTS: Patients with allergic rhinitis presented higher LTB(4) and 8-isoprostane levels in nasal lavage (P<0.0001 for both comparisons), with no significant differences between smokers and non-smokers. Patients with allergic rhinitis also presented higher LTB(4) levels and lower pH in EBC (P<0.001 and P=0.004, respectively), with prominent differences between smokers and non-smokers (P<0.0001 and P=0.003, for LTB(4) and pH, respectively). A significant correlation between nasal lavage and EBC LTB(4) values was observed (r(s)=0.313, P=0.048). CONCLUSIONS: Patients with allergic rhinitis present increased LTB(4) and 8-isoprostane in their nasal cavity, however, with no significant differences between smokers and non-smokers. In contrast, smokers with allergic rhinitis present higher LTB(4) levels and lower pH in EBC, suggesting that these patients may be more susceptible to the deleterious effects of smoking, compared with non-smokers. SN - 1365-2222 UR - https://www.unboundmedicine.com/medline/citation/19187324/Inflammatory_and_oxidative_stress_biomarkers_in_allergic_rhinitis:_the_effect_of_smoking_ L2 - https://doi.org/10.1111/j.1365-2222.2008.03149.x DB - PRIME DP - Unbound Medicine ER -