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Body composition by dual-energy X-ray absorptiometry in women with previous pre-eclampsia or small-for-gestational-age offspring.
BJOG. 2009 Feb; 116(3):442-51.BJOG

Abstract

OBJECTIVE

To investigate differences in body composition and fat distribution between women with previous pre-eclampsia or small-for-gestational-age (SGA) offspring and those with uncomplicated pregnancies.

DESIGN

Cohort study.

SETTING

Population-based study in a genetically isolated population in the southwest of the Netherlands.

POPULATION

Women after pregnancies complicated by pre-eclampsia (n=45), SGA offspring (n=53) and uncomplicated pregnancies (n=106).

METHODS

Women were compared for body composition and fat distribution variables, assessed by dual-energy X-ray absorptiometry (DXA) and anthropometrics at a mean follow-up time of 10.8 (SD +/- 5.9) years after pregnancy.

MAIN OUTCOME MEASURES

Total lean and fat mass, android fat mass, gynoid fat mass, android-to-gynoid fat ratio, waist and hip circumference, waist-to-hip ratio.

RESULTS

Women with previous pre-eclampsia compared with controls had higher mean total fat mass index (11.5 +/- 0.6 versus 9.7 +/- 0.4 kg/m(2); P = 0.03), lean mass index (15.8 +/- 0.3 versus 14.5 +/- 0.2 kg/m(2); P =0.001) and body mass index ([BMI]; 28.4 +/- 0.8 versus 25.4 +/- 0.5 kg/m(2); P = 0.005). Their waist circumferences (90.7 +/- 2.0 versus 78.5 +/- 1.3 cm; P < 0.001) and waist-to-hip ratios (0.86 +/- 0.01 versus 0.77 +/- 0.01; P < 0.001) were also higher as well as android fat mass (2.8 +/- 0.2 versus 2.1 +/- 0.1 kg; P = 0.01) and android-to-gynoid fat ratios (0.45 +/- 0.02 versus 0.39 +/- 0.01; P = 0.02). Mean total fat, lean and BMI was not significantly different between women with previous SGA offspring and controls, yet waist-to-hip ratios (0.83 +/- 0.01; P < 0.001) were higher. The observed differences in waist and hip circumference, waist-to-hip ratio and gynoid fat mass could not be attributed to differences in BMI.

CONCLUSION

Women with previous pre-eclampsia or SGA offspring pregnancies compared with those with uncomplicated pregnancies have a preferential fat accumulation in the abdominal over hip region, which may explain, at least partly, their increased cardiovascular risk.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, University Medical Center, Rotterdam, The Netherlands. a.berends@erasmusmc.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19187378

Citation

Berends, A L., et al. "Body Composition By Dual-energy X-ray Absorptiometry in Women With Previous Pre-eclampsia or Small-for-gestational-age Offspring." BJOG : an International Journal of Obstetrics and Gynaecology, vol. 116, no. 3, 2009, pp. 442-51.
Berends AL, Zillikens MC, de Groot CJ, et al. Body composition by dual-energy X-ray absorptiometry in women with previous pre-eclampsia or small-for-gestational-age offspring. BJOG. 2009;116(3):442-51.
Berends, A. L., Zillikens, M. C., de Groot, C. J., Rivadeneira, F., Oostra, B. A., van Duijn, C. M., & Steegers, E. A. (2009). Body composition by dual-energy X-ray absorptiometry in women with previous pre-eclampsia or small-for-gestational-age offspring. BJOG : an International Journal of Obstetrics and Gynaecology, 116(3), 442-51. https://doi.org/10.1111/j.1471-0528.2008.02044.x
Berends AL, et al. Body Composition By Dual-energy X-ray Absorptiometry in Women With Previous Pre-eclampsia or Small-for-gestational-age Offspring. BJOG. 2009;116(3):442-51. PubMed PMID: 19187378.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body composition by dual-energy X-ray absorptiometry in women with previous pre-eclampsia or small-for-gestational-age offspring. AU - Berends,A L, AU - Zillikens,M C, AU - de Groot,C J M, AU - Rivadeneira,F, AU - Oostra,B A, AU - van Duijn,C M, AU - Steegers,E A P, PY - 2009/2/4/entrez PY - 2009/2/4/pubmed PY - 2009/4/23/medline SP - 442 EP - 51 JF - BJOG : an international journal of obstetrics and gynaecology JO - BJOG VL - 116 IS - 3 N2 - OBJECTIVE: To investigate differences in body composition and fat distribution between women with previous pre-eclampsia or small-for-gestational-age (SGA) offspring and those with uncomplicated pregnancies. DESIGN: Cohort study. SETTING: Population-based study in a genetically isolated population in the southwest of the Netherlands. POPULATION: Women after pregnancies complicated by pre-eclampsia (n=45), SGA offspring (n=53) and uncomplicated pregnancies (n=106). METHODS: Women were compared for body composition and fat distribution variables, assessed by dual-energy X-ray absorptiometry (DXA) and anthropometrics at a mean follow-up time of 10.8 (SD +/- 5.9) years after pregnancy. MAIN OUTCOME MEASURES: Total lean and fat mass, android fat mass, gynoid fat mass, android-to-gynoid fat ratio, waist and hip circumference, waist-to-hip ratio. RESULTS: Women with previous pre-eclampsia compared with controls had higher mean total fat mass index (11.5 +/- 0.6 versus 9.7 +/- 0.4 kg/m(2); P = 0.03), lean mass index (15.8 +/- 0.3 versus 14.5 +/- 0.2 kg/m(2); P =0.001) and body mass index ([BMI]; 28.4 +/- 0.8 versus 25.4 +/- 0.5 kg/m(2); P = 0.005). Their waist circumferences (90.7 +/- 2.0 versus 78.5 +/- 1.3 cm; P < 0.001) and waist-to-hip ratios (0.86 +/- 0.01 versus 0.77 +/- 0.01; P < 0.001) were also higher as well as android fat mass (2.8 +/- 0.2 versus 2.1 +/- 0.1 kg; P = 0.01) and android-to-gynoid fat ratios (0.45 +/- 0.02 versus 0.39 +/- 0.01; P = 0.02). Mean total fat, lean and BMI was not significantly different between women with previous SGA offspring and controls, yet waist-to-hip ratios (0.83 +/- 0.01; P < 0.001) were higher. The observed differences in waist and hip circumference, waist-to-hip ratio and gynoid fat mass could not be attributed to differences in BMI. CONCLUSION: Women with previous pre-eclampsia or SGA offspring pregnancies compared with those with uncomplicated pregnancies have a preferential fat accumulation in the abdominal over hip region, which may explain, at least partly, their increased cardiovascular risk. SN - 1471-0528 UR - https://www.unboundmedicine.com/medline/citation/19187378/Body_composition_by_dual_energy_X_ray_absorptiometry_in_women_with_previous_pre_eclampsia_or_small_for_gestational_age_offspring_ L2 - https://doi.org/10.1111/j.1471-0528.2008.02044.x DB - PRIME DP - Unbound Medicine ER -