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Functional brain changes in early Parkinson's disease during motor response and motor inhibition.
Neurobiol Aging. 2011 Jan; 32(1):115-24.NA

Abstract

Motor impairment represents the main clinical feature of Parkinson's disease (PD). Cognitive deficits are also frequently observed in patients with PD, with a prominent involvement of executive functions and visuo-spatial abilities. We used event-related functional MRI (fMRI) and a paradigm based on visual attention and motor inhibition (Go/NoGO-task) to investigate brain activations in 13 patients with early PD in comparison with 11 healthy controls. The two groups did not report behavioural differences in task performance. During motor inhibition (NoGO-effect), PD patients compared to controls showed an increased activation in the prefrontal cortex and in the basal ganglia. They also showed a reduced and less coherent hemodynamic response in the occipital cortex. These results indicate that specific cortico-subcortical functional changes, involving not only the fronto-striatal network but also the temporal-occipital cortex, are already present in patients with early PD and no clinical evidence of cognitive impairment. We discuss our findings in terms of compensatory mechanisms (fronto-striatal changes) and preclinical signs of visuo-perceptual deficits and visual hallucinations.

Authors+Show Affiliations

Don Carlo Gnocchi Foundation, Scientific Institute and University, IRCCS, 20148 Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19188005

Citation

Baglio, Francesca, et al. "Functional Brain Changes in Early Parkinson's Disease During Motor Response and Motor Inhibition." Neurobiology of Aging, vol. 32, no. 1, 2011, pp. 115-24.
Baglio F, Blasi V, Falini A, et al. Functional brain changes in early Parkinson's disease during motor response and motor inhibition. Neurobiol Aging. 2011;32(1):115-24.
Baglio, F., Blasi, V., Falini, A., Farina, E., Mantovani, F., Olivotto, F., Scotti, G., Nemni, R., & Bozzali, M. (2011). Functional brain changes in early Parkinson's disease during motor response and motor inhibition. Neurobiology of Aging, 32(1), 115-24. https://doi.org/10.1016/j.neurobiolaging.2008.12.009
Baglio F, et al. Functional Brain Changes in Early Parkinson's Disease During Motor Response and Motor Inhibition. Neurobiol Aging. 2011;32(1):115-24. PubMed PMID: 19188005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional brain changes in early Parkinson's disease during motor response and motor inhibition. AU - Baglio,Francesca, AU - Blasi,Valeria, AU - Falini,Andrea, AU - Farina,Elisabetta, AU - Mantovani,Federica, AU - Olivotto,Fabrizio, AU - Scotti,Giuseppe, AU - Nemni,Raffaello, AU - Bozzali,Marco, Y1 - 2009/02/01/ PY - 2008/01/10/received PY - 2008/10/10/revised PY - 2008/12/15/accepted PY - 2009/2/4/entrez PY - 2009/2/4/pubmed PY - 2011/3/15/medline SP - 115 EP - 24 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 32 IS - 1 N2 - Motor impairment represents the main clinical feature of Parkinson's disease (PD). Cognitive deficits are also frequently observed in patients with PD, with a prominent involvement of executive functions and visuo-spatial abilities. We used event-related functional MRI (fMRI) and a paradigm based on visual attention and motor inhibition (Go/NoGO-task) to investigate brain activations in 13 patients with early PD in comparison with 11 healthy controls. The two groups did not report behavioural differences in task performance. During motor inhibition (NoGO-effect), PD patients compared to controls showed an increased activation in the prefrontal cortex and in the basal ganglia. They also showed a reduced and less coherent hemodynamic response in the occipital cortex. These results indicate that specific cortico-subcortical functional changes, involving not only the fronto-striatal network but also the temporal-occipital cortex, are already present in patients with early PD and no clinical evidence of cognitive impairment. We discuss our findings in terms of compensatory mechanisms (fronto-striatal changes) and preclinical signs of visuo-perceptual deficits and visual hallucinations. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/19188005/Functional_brain_changes_in_early_Parkinson's_disease_during_motor_response_and_motor_inhibition_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(08)00426-0 DB - PRIME DP - Unbound Medicine ER -