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MDMA reinstates cocaine-seeking behaviour in mice.
Eur Neuropsychopharmacol. 2009 Jun; 19(6):391-7.EN

Abstract

BACKGROUND

MDMA effects are mediated by monoaminergic systems, which seem to play a central role in cocaine craving and relapse.

METHODS

CD1 mice trained to self-administer cocaine (1 mg/kg/infusion) underwent an extinction procedure in which the cues contingent with drug self-administration remained present. Mice achieving extinction were injected with MDMA (10 mg/kg), d-amphetamine (1 and 2 mg/kg) or saline and tested for reinstatement.

RESULTS

Acute MDMA, but not d-amphetamine or saline reinstated cocaine-seeking behaviour in mice in which cocaine self-administration and contingent cues were previously extinguished.

CONCLUSIONS

Acute MDMA can reinstate cocaine-seeking behaviour in mice.

Authors+Show Affiliations

Laboratori de Neurofarmacologia, Departament de Ciències Experimentals i de la Salud, Universitat Pompeu Fabra, Calle Dr. Aiguader 88, 08003 Barcelona, Spain. jose.trigo@upf.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19188047

Citation

Trigo, José Manuel, et al. "MDMA Reinstates Cocaine-seeking Behaviour in Mice." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 19, no. 6, 2009, pp. 391-7.
Trigo JM, Orejarena MJ, Maldonado R, et al. MDMA reinstates cocaine-seeking behaviour in mice. Eur Neuropsychopharmacol. 2009;19(6):391-7.
Trigo, J. M., Orejarena, M. J., Maldonado, R., & Robledo, P. (2009). MDMA reinstates cocaine-seeking behaviour in mice. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 19(6), 391-7. https://doi.org/10.1016/j.euroneuro.2008.12.010
Trigo JM, et al. MDMA Reinstates Cocaine-seeking Behaviour in Mice. Eur Neuropsychopharmacol. 2009;19(6):391-7. PubMed PMID: 19188047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MDMA reinstates cocaine-seeking behaviour in mice. AU - Trigo,José Manuel, AU - Orejarena,Maria Juliana, AU - Maldonado,Rafael, AU - Robledo,Patricia, Y1 - 2009/02/01/ PY - 2008/05/08/received PY - 2008/12/10/revised PY - 2008/12/23/accepted PY - 2009/2/4/entrez PY - 2009/2/4/pubmed PY - 2009/6/26/medline SP - 391 EP - 7 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 19 IS - 6 N2 - BACKGROUND: MDMA effects are mediated by monoaminergic systems, which seem to play a central role in cocaine craving and relapse. METHODS: CD1 mice trained to self-administer cocaine (1 mg/kg/infusion) underwent an extinction procedure in which the cues contingent with drug self-administration remained present. Mice achieving extinction were injected with MDMA (10 mg/kg), d-amphetamine (1 and 2 mg/kg) or saline and tested for reinstatement. RESULTS: Acute MDMA, but not d-amphetamine or saline reinstated cocaine-seeking behaviour in mice in which cocaine self-administration and contingent cues were previously extinguished. CONCLUSIONS: Acute MDMA can reinstate cocaine-seeking behaviour in mice. SN - 1873-7862 UR - https://www.unboundmedicine.com/medline/citation/19188047/MDMA_reinstates_cocaine_seeking_behaviour_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-977X(09)00006-6 DB - PRIME DP - Unbound Medicine ER -