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Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder.
Arch Gen Psychiatry. 2009 Feb; 66(2):142-51.AG

Abstract

CONTEXT

Structural neuroimaging studies suggest the presence of subtle abnormalities in the brains of patients with bipolar disorder. The influence of genetic and/or environmental factors on these brain abnormalities is unknown.

OBJECTIVE

To investigate the contribution of genetic and environmental factors on brain volume in bipolar disorder.

DESIGN

Magnetic resonance imaging (1.5 T) brain scans of monozygotic (MZ) or dizygotic (DZ) twins concordant and discordant for bipolar disorder were compared with healthy twin pairs.

SETTING

Subjects were recruited from the population, the Netherlands Twin Register, and the twin pair cohort at the University Medical Center Utrecht, Utrecht, The Netherlands.

PARTICIPANTS

A total of 234 subjects including 50 affected twin pairs (9 MZ concordant; 15 MZ discordant; 4 DZ concordant; 22 DZ discordant) and 67 healthy twin pairs (39 MZ and 28 DZ) were included.

MAIN OUTCOME MEASURES

Volumes of the intracranium, cerebrum, cerebellum, lateral and third ventricle, and gray and white matter from the cerebrum and frontal, parietal, temporal, and occipital lobes, both with and without correction for lithium use. To estimate the influence of additive genetic, common, and unique environmental factors, structural equation modeling was applied.

RESULTS

Bipolar disorder was associated with a decrease in total cortical volume. Decreases in white matter were related to the genetic risk of developing bipolar disorder (bivariate heritability, 77%; 95% confidence interval, 38% to 100%). Significant environmental correlations were found for cortical gray matter. These relationships all became more pronounced when data were corrected for lithium use.

CONCLUSIONS

Focusing on genes controlling white matter integrity may be a fruitful strategy in the quest to discover genes implicated in bipolar disorder. Elucidating the mechanism by which lithium attenuates brain matter loss may lead to the development of neuroprotective drugs.

Authors+Show Affiliations

Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

19188536

Citation

van der Schot, Astrid C., et al. "Influence of Genes and Environment On Brain Volumes in Twin Pairs Concordant and Discordant for Bipolar Disorder." Archives of General Psychiatry, vol. 66, no. 2, 2009, pp. 142-51.
van der Schot AC, Vonk R, Brans RG, et al. Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder. Arch Gen Psychiatry. 2009;66(2):142-51.
van der Schot, A. C., Vonk, R., Brans, R. G., van Haren, N. E., Koolschijn, P. C., Nuboer, V., Schnack, H. G., van Baal, G. C., Boomsma, D. I., Nolen, W. A., Hulshoff Pol, H. E., & Kahn, R. S. (2009). Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder. Archives of General Psychiatry, 66(2), 142-51. https://doi.org/10.1001/archgenpsychiatry.2008.541
van der Schot AC, et al. Influence of Genes and Environment On Brain Volumes in Twin Pairs Concordant and Discordant for Bipolar Disorder. Arch Gen Psychiatry. 2009;66(2):142-51. PubMed PMID: 19188536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder. AU - van der Schot,Astrid C, AU - Vonk,Ronald, AU - Brans,Rachel G H, AU - van Haren,Neeltje E M, AU - Koolschijn,P Cédric M P, AU - Nuboer,Valerie, AU - Schnack,Hugo G, AU - van Baal,G Caroline M, AU - Boomsma,Dorret I, AU - Nolen,Willem A, AU - Hulshoff Pol,Hilleke E, AU - Kahn,René S, PY - 2009/2/4/entrez PY - 2009/2/4/pubmed PY - 2009/3/3/medline SP - 142 EP - 51 JF - Archives of general psychiatry JO - Arch Gen Psychiatry VL - 66 IS - 2 N2 - CONTEXT: Structural neuroimaging studies suggest the presence of subtle abnormalities in the brains of patients with bipolar disorder. The influence of genetic and/or environmental factors on these brain abnormalities is unknown. OBJECTIVE: To investigate the contribution of genetic and environmental factors on brain volume in bipolar disorder. DESIGN: Magnetic resonance imaging (1.5 T) brain scans of monozygotic (MZ) or dizygotic (DZ) twins concordant and discordant for bipolar disorder were compared with healthy twin pairs. SETTING: Subjects were recruited from the population, the Netherlands Twin Register, and the twin pair cohort at the University Medical Center Utrecht, Utrecht, The Netherlands. PARTICIPANTS: A total of 234 subjects including 50 affected twin pairs (9 MZ concordant; 15 MZ discordant; 4 DZ concordant; 22 DZ discordant) and 67 healthy twin pairs (39 MZ and 28 DZ) were included. MAIN OUTCOME MEASURES: Volumes of the intracranium, cerebrum, cerebellum, lateral and third ventricle, and gray and white matter from the cerebrum and frontal, parietal, temporal, and occipital lobes, both with and without correction for lithium use. To estimate the influence of additive genetic, common, and unique environmental factors, structural equation modeling was applied. RESULTS: Bipolar disorder was associated with a decrease in total cortical volume. Decreases in white matter were related to the genetic risk of developing bipolar disorder (bivariate heritability, 77%; 95% confidence interval, 38% to 100%). Significant environmental correlations were found for cortical gray matter. These relationships all became more pronounced when data were corrected for lithium use. CONCLUSIONS: Focusing on genes controlling white matter integrity may be a fruitful strategy in the quest to discover genes implicated in bipolar disorder. Elucidating the mechanism by which lithium attenuates brain matter loss may lead to the development of neuroprotective drugs. SN - 1538-3636 UR - https://www.unboundmedicine.com/medline/citation/19188536/Influence_of_genes_and_environment_on_brain_volumes_in_twin_pairs_concordant_and_discordant_for_bipolar_disorder_ L2 - https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/archgenpsychiatry.2008.541 DB - PRIME DP - Unbound Medicine ER -