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Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma.
Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1536-41.PN

Abstract

Atopic dermatitis (AD) is often the initial step in the "atopic march," given that more than half of AD patients with moderate to severe AD develop asthma later in life. Both AD and asthma share a similar "atopy" phenotype that includes T helper type 2 inflammation with eosinophilia and hyper-IgE immunoglobulinemia, but the molecular mechanisms underlying the "atopic march" remain elusive. In the present study, we show that induced expression of thymic stromal lymphopoietin (TSLP) in mouse epidermal keratinocytes upon topical application of MC903 (a low calcemic analogue of vitamin D3) not only triggers AD as we previously reported but also aggravates experimental allergic asthma induced by ovalbumin sensitization and challenge. Our study, which provides a mouse model to study human "atopic march," indicates that keratinocyte-produced TSLP may represent an important factor in the link of atopic dermatitis to asthma.

Authors+Show Affiliations

Department of Functional Genomics, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique/Institut National de la Santé et de la Recherche Médicale/Université Louis Pasteur, 67404 Illkirch, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19188585

Citation

Zhang, Zhikun, et al. "Thymic Stromal Lymphopoietin Overproduced By Keratinocytes in Mouse Skin Aggravates Experimental Asthma." Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 5, 2009, pp. 1536-41.
Zhang Z, Hener P, Frossard N, et al. Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma. Proc Natl Acad Sci U S A. 2009;106(5):1536-41.
Zhang, Z., Hener, P., Frossard, N., Kato, S., Metzger, D., Li, M., & Chambon, P. (2009). Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma. Proceedings of the National Academy of Sciences of the United States of America, 106(5), 1536-41. https://doi.org/10.1073/pnas.0812668106
Zhang Z, et al. Thymic Stromal Lymphopoietin Overproduced By Keratinocytes in Mouse Skin Aggravates Experimental Asthma. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1536-41. PubMed PMID: 19188585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma. AU - Zhang,Zhikun, AU - Hener,Pierre, AU - Frossard,Nelly, AU - Kato,Shigeaki, AU - Metzger,Daniel, AU - Li,Mei, AU - Chambon,Pierre, Y1 - 2009/02/02/ PY - 2009/2/4/entrez PY - 2009/2/4/pubmed PY - 2009/2/28/medline SP - 1536 EP - 41 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc Natl Acad Sci U S A VL - 106 IS - 5 N2 - Atopic dermatitis (AD) is often the initial step in the "atopic march," given that more than half of AD patients with moderate to severe AD develop asthma later in life. Both AD and asthma share a similar "atopy" phenotype that includes T helper type 2 inflammation with eosinophilia and hyper-IgE immunoglobulinemia, but the molecular mechanisms underlying the "atopic march" remain elusive. In the present study, we show that induced expression of thymic stromal lymphopoietin (TSLP) in mouse epidermal keratinocytes upon topical application of MC903 (a low calcemic analogue of vitamin D3) not only triggers AD as we previously reported but also aggravates experimental allergic asthma induced by ovalbumin sensitization and challenge. Our study, which provides a mouse model to study human "atopic march," indicates that keratinocyte-produced TSLP may represent an important factor in the link of atopic dermatitis to asthma. SN - 1091-6490 UR - https://www.unboundmedicine.com/medline/citation/19188585/Thymic_stromal_lymphopoietin_overproduced_by_keratinocytes_in_mouse_skin_aggravates_experimental_asthma_ L2 - http://www.pnas.org/cgi/pmidlookup?view=long&pmid=19188585 DB - PRIME DP - Unbound Medicine ER -