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Effects of Hypericum perforatum (St. John's wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial.
Menopause. 2009 Mar-Apr; 16(2):307-14.M

Abstract

OBJECTIVE

The aim of this pilot double-blind, randomized clinical trial, which initially targeted breast cancer survivors, was to obtain preliminary evidence of the effect of Hypericum perforatum extract (St. John's wort extract) compared with placebo on symptoms and quality of life of symptomatic perimenopausal women. We also assessed practical difficulties in recruiting women to such a trial.

METHODS

Symptomatic perimenopausal women aged 40 to 65 years who experience hot flashes (three or more per day, Heart and Estrogen/Progestin Replacement Study scale) were randomly assigned to receive ethanolic St. John's wort extract (900 mg TID) or placebo. The women were asked to keep a daily diary during the week before randomization and during the week before the 3-month follow-up (primary outcome) to record hot flash frequency and intensity. A hot flash score (frequency x severity) was calculated. The Menopause-Specific Quality of Life questionnaire was used to assess menopause-specific quality of life.

RESULTS

Forty-seven women were randomized. After 12 weeks of treatment, a nonsignificant difference favoring the St. John's wort group was observed in the daily hot flash frequency (St. John's wort, -2.3 +/- 3.6; placebo, -1.0 +/- 2.2; P = 0.11) and the hot flash score (-3.8 +/- 8.3 and -1.8 +/- 6.5, respectively; P = 0.10). After 3 months of treatment, compared with the placebo group, women in the St. John's wort group reported significantly better menopause-specific quality of life (P = 0.01) and significantly fewer sleep problems (P = 0.05).

CONCLUSIONS

Hypericum perforatum may improve quality of life in ways that are important to symptomatic perimenopausal women, but these results need to be confirmed by a larger clinical trial.

Authors+Show Affiliations

Centre de Recherche, Centre Hospitalier Universitaire du Québec, Québec, QC, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19194342

Citation

Al-Akoum, Mahéra, et al. "Effects of Hypericum Perforatum (St. John's Wort) On Hot Flashes and Quality of Life in Perimenopausal Women: a Randomized Pilot Trial." Menopause (New York, N.Y.), vol. 16, no. 2, 2009, pp. 307-14.
Al-Akoum M, Maunsell E, Verreault R, et al. Effects of Hypericum perforatum (St. John's wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial. Menopause. 2009;16(2):307-14.
Al-Akoum, M., Maunsell, E., Verreault, R., Provencher, L., Otis, H., & Dodin, S. (2009). Effects of Hypericum perforatum (St. John's wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial. Menopause (New York, N.Y.), 16(2), 307-14. https://doi.org/10.1097/gme.0b013e31818572a0
Al-Akoum M, et al. Effects of Hypericum Perforatum (St. John's Wort) On Hot Flashes and Quality of Life in Perimenopausal Women: a Randomized Pilot Trial. Menopause. 2009 Mar-Apr;16(2):307-14. PubMed PMID: 19194342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Hypericum perforatum (St. John's wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial. AU - Al-Akoum,Mahéra, AU - Maunsell,Elizabeth, AU - Verreault,René, AU - Provencher,Louise, AU - Otis,Hélène, AU - Dodin,Sylvie, PY - 2009/2/6/entrez PY - 2009/2/6/pubmed PY - 2009/10/29/medline SP - 307 EP - 14 JF - Menopause (New York, N.Y.) JO - Menopause VL - 16 IS - 2 N2 - OBJECTIVE: The aim of this pilot double-blind, randomized clinical trial, which initially targeted breast cancer survivors, was to obtain preliminary evidence of the effect of Hypericum perforatum extract (St. John's wort extract) compared with placebo on symptoms and quality of life of symptomatic perimenopausal women. We also assessed practical difficulties in recruiting women to such a trial. METHODS: Symptomatic perimenopausal women aged 40 to 65 years who experience hot flashes (three or more per day, Heart and Estrogen/Progestin Replacement Study scale) were randomly assigned to receive ethanolic St. John's wort extract (900 mg TID) or placebo. The women were asked to keep a daily diary during the week before randomization and during the week before the 3-month follow-up (primary outcome) to record hot flash frequency and intensity. A hot flash score (frequency x severity) was calculated. The Menopause-Specific Quality of Life questionnaire was used to assess menopause-specific quality of life. RESULTS: Forty-seven women were randomized. After 12 weeks of treatment, a nonsignificant difference favoring the St. John's wort group was observed in the daily hot flash frequency (St. John's wort, -2.3 +/- 3.6; placebo, -1.0 +/- 2.2; P = 0.11) and the hot flash score (-3.8 +/- 8.3 and -1.8 +/- 6.5, respectively; P = 0.10). After 3 months of treatment, compared with the placebo group, women in the St. John's wort group reported significantly better menopause-specific quality of life (P = 0.01) and significantly fewer sleep problems (P = 0.05). CONCLUSIONS: Hypericum perforatum may improve quality of life in ways that are important to symptomatic perimenopausal women, but these results need to be confirmed by a larger clinical trial. SN - 1530-0374 UR - https://www.unboundmedicine.com/medline/citation/19194342/Effects_of_Hypericum_perforatum__St__John's_wort__on_hot_flashes_and_quality_of_life_in_perimenopausal_women:_a_randomized_pilot_trial_ L2 - https://doi.org/10.1097/gme.0b013e31818572a0 DB - PRIME DP - Unbound Medicine ER -