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Definition and natural history of metabolic steatosis: clinical aspects of NAFLD, NASH and cirrhosis.
Diabetes Metab. 2008 Dec; 34(6 Pt 2):634-7.DM

Abstract

Metabolic steatosis or non-alcoholic fatty liver (NAFLD) is the most common cause of chronic liver injury in Western countries. Histological signs of necroinflammation, indicating the presence of non-alcoholic steatohepatitis (NASH), are present in 20-30% of cases. While steatosis on its own has a benign course, NASH may be associated with fibrosis and may progress to cirrhosis, terminal liver failure and hepatocellular carcinoma. NAFLD is closely associated with the metabolic syndrome, its prevalence reaching 50-90% in obese patients. The clinical impact of NAFLD has been demonstrated in large cohort studies by the overprevalence of cirrhosis and hepatocellular carcinoma in obese and diabetic patients. In terms of survival, liver disease is the third most common cause of mortality in patients with NAFLD. When associated with other causes of liver disease such as alcohol consumption or hepatitis C infection, metabolic steatosis may be a major risk factor for disease progression.

Authors+Show Affiliations

Service d'Hépatologie, Hôpital Saint-Antoine, 75571 Paris cedex 12, France. lawrence.serfaty@sat.aphp.frNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19195623

Citation

Serfaty, L, and M Lemoine. "Definition and Natural History of Metabolic Steatosis: Clinical Aspects of NAFLD, NASH and Cirrhosis." Diabetes & Metabolism, vol. 34, no. 6 Pt 2, 2008, pp. 634-7.
Serfaty L, Lemoine M. Definition and natural history of metabolic steatosis: clinical aspects of NAFLD, NASH and cirrhosis. Diabetes Metab. 2008;34(6 Pt 2):634-7.
Serfaty, L., & Lemoine, M. (2008). Definition and natural history of metabolic steatosis: clinical aspects of NAFLD, NASH and cirrhosis. Diabetes & Metabolism, 34(6 Pt 2), 634-7. https://doi.org/10.1016/S1262-3636(08)74597-X
Serfaty L, Lemoine M. Definition and Natural History of Metabolic Steatosis: Clinical Aspects of NAFLD, NASH and Cirrhosis. Diabetes Metab. 2008;34(6 Pt 2):634-7. PubMed PMID: 19195623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Definition and natural history of metabolic steatosis: clinical aspects of NAFLD, NASH and cirrhosis. AU - Serfaty,L, AU - Lemoine,M, PY - 2009/2/7/entrez PY - 2009/2/7/pubmed PY - 2009/3/25/medline SP - 634 EP - 7 JF - Diabetes & metabolism JO - Diabetes Metab VL - 34 IS - 6 Pt 2 N2 - Metabolic steatosis or non-alcoholic fatty liver (NAFLD) is the most common cause of chronic liver injury in Western countries. Histological signs of necroinflammation, indicating the presence of non-alcoholic steatohepatitis (NASH), are present in 20-30% of cases. While steatosis on its own has a benign course, NASH may be associated with fibrosis and may progress to cirrhosis, terminal liver failure and hepatocellular carcinoma. NAFLD is closely associated with the metabolic syndrome, its prevalence reaching 50-90% in obese patients. The clinical impact of NAFLD has been demonstrated in large cohort studies by the overprevalence of cirrhosis and hepatocellular carcinoma in obese and diabetic patients. In terms of survival, liver disease is the third most common cause of mortality in patients with NAFLD. When associated with other causes of liver disease such as alcohol consumption or hepatitis C infection, metabolic steatosis may be a major risk factor for disease progression. SN - 1262-3636 UR - https://www.unboundmedicine.com/medline/citation/19195623/Definition_and_natural_history_of_metabolic_steatosis:_clinical_aspects_of_NAFLD_NASH_and_cirrhosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1262-3636(08)74597-X DB - PRIME DP - Unbound Medicine ER -