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Improvements in body fat distribution and circulating adiponectin by alternate-day fasting versus calorie restriction.
J Nutr Biochem. 2010 Mar; 21(3):188-95.JN

Abstract

Calorie restriction (CR) and alternate-day fasting (ADF) beneficially affect several aspects of adipose tissue physiology, but direct comparisons between regimens have yet to be performed. The present study evaluated the effects of ADF versus CR on body fat distribution and circulating adiponectin levels and examined the kinetic mechanisms that underlie changes in fat distribution. Thirty female C57BL/6J mice were randomized to one of five groups for 4 weeks: (a) CR-25% (25% energy restriction daily), (b) ADF-75% (75% restriction on fast day), (c) ADF-85% (85% restriction on fast day), (d) ADF-100% (100% restriction on fast day) and (e) control (ad libitum fed). Body weights of the CR mice were lower than that of the ADF and control groups posttreatment. After 4 weeks of diet, the proportion of visceral fat decreased (P<.001) and the proportion of subcutaneous fat increased (P<.001) similarly in ADF and CR animals. Adiponectin increased (P<.05) by 62-86% in the ADF groups and by 69% in the CR group. Triglyceride (TG) synthesis and de novo lipogenesis were augmented (P<.05) in the subcutaneous fat pad of ADF and CR animals, relative to control. No differences in net lipolysis were observed, resulting in greater TG accumulation in the subcutaneous fat pad, with a shift in the ratio of TG between depots. These findings indicate that ADF (both modified and true) produces similar beneficial modulations in body fat distribution and adiponectin levels as daily CR.

Authors+Show Affiliations

Department of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, CA 94720, USA. kvarady@nature.berkeley.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19195863

Citation

Varady, Krista A., et al. "Improvements in Body Fat Distribution and Circulating Adiponectin By Alternate-day Fasting Versus Calorie Restriction." The Journal of Nutritional Biochemistry, vol. 21, no. 3, 2010, pp. 188-95.
Varady KA, Allister CA, Roohk DJ, et al. Improvements in body fat distribution and circulating adiponectin by alternate-day fasting versus calorie restriction. J Nutr Biochem. 2010;21(3):188-95.
Varady, K. A., Allister, C. A., Roohk, D. J., & Hellerstein, M. K. (2010). Improvements in body fat distribution and circulating adiponectin by alternate-day fasting versus calorie restriction. The Journal of Nutritional Biochemistry, 21(3), 188-95. https://doi.org/10.1016/j.jnutbio.2008.11.001
Varady KA, et al. Improvements in Body Fat Distribution and Circulating Adiponectin By Alternate-day Fasting Versus Calorie Restriction. J Nutr Biochem. 2010;21(3):188-95. PubMed PMID: 19195863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improvements in body fat distribution and circulating adiponectin by alternate-day fasting versus calorie restriction. AU - Varady,Krista A, AU - Allister,Candice A, AU - Roohk,Donald J, AU - Hellerstein,Marc K, Y1 - 2009/02/05/ PY - 2008/06/04/received PY - 2008/09/02/revised PY - 2008/11/03/accepted PY - 2009/2/7/entrez PY - 2009/2/7/pubmed PY - 2010/5/7/medline SP - 188 EP - 95 JF - The Journal of nutritional biochemistry JO - J Nutr Biochem VL - 21 IS - 3 N2 - Calorie restriction (CR) and alternate-day fasting (ADF) beneficially affect several aspects of adipose tissue physiology, but direct comparisons between regimens have yet to be performed. The present study evaluated the effects of ADF versus CR on body fat distribution and circulating adiponectin levels and examined the kinetic mechanisms that underlie changes in fat distribution. Thirty female C57BL/6J mice were randomized to one of five groups for 4 weeks: (a) CR-25% (25% energy restriction daily), (b) ADF-75% (75% restriction on fast day), (c) ADF-85% (85% restriction on fast day), (d) ADF-100% (100% restriction on fast day) and (e) control (ad libitum fed). Body weights of the CR mice were lower than that of the ADF and control groups posttreatment. After 4 weeks of diet, the proportion of visceral fat decreased (P<.001) and the proportion of subcutaneous fat increased (P<.001) similarly in ADF and CR animals. Adiponectin increased (P<.05) by 62-86% in the ADF groups and by 69% in the CR group. Triglyceride (TG) synthesis and de novo lipogenesis were augmented (P<.05) in the subcutaneous fat pad of ADF and CR animals, relative to control. No differences in net lipolysis were observed, resulting in greater TG accumulation in the subcutaneous fat pad, with a shift in the ratio of TG between depots. These findings indicate that ADF (both modified and true) produces similar beneficial modulations in body fat distribution and adiponectin levels as daily CR. SN - 1873-4847 UR - https://www.unboundmedicine.com/medline/citation/19195863/Improvements_in_body_fat_distribution_and_circulating_adiponectin_by_alternate_day_fasting_versus_calorie_restriction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(08)00247-7 DB - PRIME DP - Unbound Medicine ER -