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Higher HDL cholesterol levels are associated with a lower incidence of chronic kidney disease in patients with type 2 diabetes.
Nutr Metab Cardiovasc Dis. 2009 Oct; 19(8):580-6.NM

Abstract

BACKGROUND AND AIMS

Type 2 diabetes is one of the most important risk factor for the development of chronic kidney disease (CKD). Recently, it has been shown that lower high-density lipoprotein cholesterol (HDL-C) levels predicted the development of microalbuminuria in type 2 diabetic individuals. We have prospectively assessed the effects of plasma HDL-C levels on the incidence of CKD in a large cohort of type 2 diabetic patients.

METHODS AND RESULTS

We followed 1987 type 2 diabetic outpatients with normal or near-normal kidney function at baseline for 5 years for the occurrence of incident CKD defined as glomerular filtration rate < or = 60 mL/min/1.73 m(2) (as estimated by the abbreviated Modified Diet and Renal Disease Study equation). Cox proportional hazards models were used to examine the independent relationship between plasma HDL-C levels and incident CKD. During a median follow-up of 5 years, 11.8% (n=234) of participants developed incident CKD. In multivariate regression analysis, higher HDL-C levels were associated with a lower risk of incident CKD (multiple-adjusted hazard ratio 0.76; 95% coefficient intervals 0.61-0.96; p=0.025) independently of age, gender, body mass index, hypertension, smoking history, diabetes duration, hemoglobin A1c, plasma triglycerides, LDL-cholesterol, presence of diabetic retinopathy, baseline albuminuria, and current use of medications (anti-hypertensive, anti-platelet, lipid-lowering and hypoglycemic drugs).

CONCLUSIONS

Higher plasma levels of HDL-C are associated with a lower risk of incident CKD in a large cohort of type 2 diabetic adults independently of numerous confounding factors.

Authors+Show Affiliations

Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1, 37126 Verona, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19196499

Citation

Zoppini, G, et al. "Higher HDL Cholesterol Levels Are Associated With a Lower Incidence of Chronic Kidney Disease in Patients With Type 2 Diabetes." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 19, no. 8, 2009, pp. 580-6.
Zoppini G, Targher G, Chonchol M, et al. Higher HDL cholesterol levels are associated with a lower incidence of chronic kidney disease in patients with type 2 diabetes. Nutr Metab Cardiovasc Dis. 2009;19(8):580-6.
Zoppini, G., Targher, G., Chonchol, M., Perrone, F., Lippi, G., & Muggeo, M. (2009). Higher HDL cholesterol levels are associated with a lower incidence of chronic kidney disease in patients with type 2 diabetes. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 19(8), 580-6. https://doi.org/10.1016/j.numecd.2008.11.003
Zoppini G, et al. Higher HDL Cholesterol Levels Are Associated With a Lower Incidence of Chronic Kidney Disease in Patients With Type 2 Diabetes. Nutr Metab Cardiovasc Dis. 2009;19(8):580-6. PubMed PMID: 19196499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher HDL cholesterol levels are associated with a lower incidence of chronic kidney disease in patients with type 2 diabetes. AU - Zoppini,G, AU - Targher,G, AU - Chonchol,M, AU - Perrone,F, AU - Lippi,G, AU - Muggeo,M, Y1 - 2009/02/03/ PY - 2008/08/22/received PY - 2008/10/17/revised PY - 2008/11/10/accepted PY - 2009/2/7/entrez PY - 2009/2/7/pubmed PY - 2009/12/16/medline SP - 580 EP - 6 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 19 IS - 8 N2 - BACKGROUND AND AIMS: Type 2 diabetes is one of the most important risk factor for the development of chronic kidney disease (CKD). Recently, it has been shown that lower high-density lipoprotein cholesterol (HDL-C) levels predicted the development of microalbuminuria in type 2 diabetic individuals. We have prospectively assessed the effects of plasma HDL-C levels on the incidence of CKD in a large cohort of type 2 diabetic patients. METHODS AND RESULTS: We followed 1987 type 2 diabetic outpatients with normal or near-normal kidney function at baseline for 5 years for the occurrence of incident CKD defined as glomerular filtration rate < or = 60 mL/min/1.73 m(2) (as estimated by the abbreviated Modified Diet and Renal Disease Study equation). Cox proportional hazards models were used to examine the independent relationship between plasma HDL-C levels and incident CKD. During a median follow-up of 5 years, 11.8% (n=234) of participants developed incident CKD. In multivariate regression analysis, higher HDL-C levels were associated with a lower risk of incident CKD (multiple-adjusted hazard ratio 0.76; 95% coefficient intervals 0.61-0.96; p=0.025) independently of age, gender, body mass index, hypertension, smoking history, diabetes duration, hemoglobin A1c, plasma triglycerides, LDL-cholesterol, presence of diabetic retinopathy, baseline albuminuria, and current use of medications (anti-hypertensive, anti-platelet, lipid-lowering and hypoglycemic drugs). CONCLUSIONS: Higher plasma levels of HDL-C are associated with a lower risk of incident CKD in a large cohort of type 2 diabetic adults independently of numerous confounding factors. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/19196499/Higher_HDL_cholesterol_levels_are_associated_with_a_lower_incidence_of_chronic_kidney_disease_in_patients_with_type_2_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(08)00230-5 DB - PRIME DP - Unbound Medicine ER -