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Comparison of the developmental effects of 5-methoxy-N,N-diisopropyltryptamine (Foxy) to (+/-)-3,4-methylenedioxymethamphetamine (ecstasy) in rats.
Psychopharmacology (Berl). 2009 Jun; 204(2):287-97.P

Abstract

RATIONALE

We have previously shown that (+/-)-3,4-methylenedioxymethamphetamine (MDMA) treatment from postnatal days (P)11 to P20 leads to learning and memory deficits when the animals are tested as adults. Recently, the club drug 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) has gained popularity.

OBJECTIVE

Due to the similarities between MDMA and 5-MeO-DIPT and the substitution of 5-MeO-DIPT for MDMA, the purpose of this study was to compare the developmental effects of these drugs.

METHODS

Within a litter, animals were treated from P11 to P20 with either MDMA, 5-MeO-DIPT, or saline.

RESULTS

MDMA-treated animals showed increased anxiety in a measure of defensive marble burying, as well as deficits in spatial and path integration learning. 5-MeO-DIPT-treated animals showed spatial learning deficits; however, there were no deficits observed in spatial memory or path integration learning. 5-MeO-DIPT-treated animals also showed hyperactivity in response to a challenge dose of methamphetamine.

CONCLUSIONS

The results show that treatment with either 5-MeO-DIPT or MDMA during development results in cognitive deficits and other behavioral changes but the pattern of effects is distinct for each drug.

Authors+Show Affiliations

Division of Neurology, Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19198809

Citation

Skelton, Matthew R., et al. "Comparison of the Developmental Effects of 5-methoxy-N,N-diisopropyltryptamine (Foxy) to (+/-)-3,4-methylenedioxymethamphetamine (ecstasy) in Rats." Psychopharmacology, vol. 204, no. 2, 2009, pp. 287-97.
Skelton MR, Schaefer TL, Herring NR, et al. Comparison of the developmental effects of 5-methoxy-N,N-diisopropyltryptamine (Foxy) to (+/-)-3,4-methylenedioxymethamphetamine (ecstasy) in rats. Psychopharmacology (Berl). 2009;204(2):287-97.
Skelton, M. R., Schaefer, T. L., Herring, N. R., Grace, C. E., Vorhees, C. V., & Williams, M. T. (2009). Comparison of the developmental effects of 5-methoxy-N,N-diisopropyltryptamine (Foxy) to (+/-)-3,4-methylenedioxymethamphetamine (ecstasy) in rats. Psychopharmacology, 204(2), 287-97. https://doi.org/10.1007/s00213-009-1459-x
Skelton MR, et al. Comparison of the Developmental Effects of 5-methoxy-N,N-diisopropyltryptamine (Foxy) to (+/-)-3,4-methylenedioxymethamphetamine (ecstasy) in Rats. Psychopharmacology (Berl). 2009;204(2):287-97. PubMed PMID: 19198809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the developmental effects of 5-methoxy-N,N-diisopropyltryptamine (Foxy) to (+/-)-3,4-methylenedioxymethamphetamine (ecstasy) in rats. AU - Skelton,Matthew R, AU - Schaefer,Tori L, AU - Herring,Nicole R, AU - Grace,Curtis E, AU - Vorhees,Charles V, AU - Williams,Michael T, Y1 - 2009/02/06/ PY - 2008/09/17/received PY - 2008/12/30/accepted PY - 2009/2/10/entrez PY - 2009/2/10/pubmed PY - 2009/8/6/medline SP - 287 EP - 97 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 204 IS - 2 N2 - RATIONALE: We have previously shown that (+/-)-3,4-methylenedioxymethamphetamine (MDMA) treatment from postnatal days (P)11 to P20 leads to learning and memory deficits when the animals are tested as adults. Recently, the club drug 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) has gained popularity. OBJECTIVE: Due to the similarities between MDMA and 5-MeO-DIPT and the substitution of 5-MeO-DIPT for MDMA, the purpose of this study was to compare the developmental effects of these drugs. METHODS: Within a litter, animals were treated from P11 to P20 with either MDMA, 5-MeO-DIPT, or saline. RESULTS: MDMA-treated animals showed increased anxiety in a measure of defensive marble burying, as well as deficits in spatial and path integration learning. 5-MeO-DIPT-treated animals showed spatial learning deficits; however, there were no deficits observed in spatial memory or path integration learning. 5-MeO-DIPT-treated animals also showed hyperactivity in response to a challenge dose of methamphetamine. CONCLUSIONS: The results show that treatment with either 5-MeO-DIPT or MDMA during development results in cognitive deficits and other behavioral changes but the pattern of effects is distinct for each drug. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/19198809/Comparison_of_the_developmental_effects_of_5_methoxy_NN_diisopropyltryptamine__Foxy__to__+/___34_methylenedioxymethamphetamine__ecstasy__in_rats_ L2 - https://dx.doi.org/10.1007/s00213-009-1459-x DB - PRIME DP - Unbound Medicine ER -