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[The Pvu II and Xba I polymorphisms in the estrogen receptor alpha gene in Chinese patients with severe preeclampsia].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009 Feb; 26(1):40-4.ZY

Abstract

OBJECTIVE

To assess the allele and genotype frequencies of the estrogen receptor alpha (ESR alpha) Pvu II and Xba I polymorphisms in patients with severe preeclampsia and compare them with those of normal pregnant women.

METHODS

Blood samples from 131 patients with severe preeclampsia and 223 normal pregnant women from Chinese Han in Chengdu area were analyzed, using PCR-RFLP method. Pregnant patients with blood pressure exceeding 140/90 mmHg (or 18.7/12 kPa) were recruited with a strict definition of preeclampsia. Genotyping was performed using PCR-RFLP for Pvu II and Xba I polymorphisms in the ESR alpha gene.

RESULTS

The T and C allele frequencies for Pvu II site were 0.580 and 0.420 in the patient group, and 0.576 and 0.424 in the controls, respectively. The A and G allele frequencies for Xba I site were 0.763 and 0.237 in the patient group, and 0.807 and 0.193 in control group, respectively. No significant difference in the allele frequencies of either site was observed between the two groups. However, the CC homozygotes or CT heterozygotes in the control pregnant women had higher systolic blood pressure levels than TT homozygotes for Pvu II site after the data was adjusted for age and BMI (114.00+/-21.44 mmHg or 114.33+/-1.21 mmHg vs. 108.62+/-1.91 mmHg, P<0.05). No genotype effect on the blood pressures was found for Pvu II site in the case group, nor for Xba I site in either group.

CONCLUSION

Our work has excluded the association of the ESRalpha Pvu II and Xb I polymorphism with severe preeclampsia in a Southwest Chinese population, although this polymorphism may be associated with the systolic blood pressure level in the normal pregnant women.

Authors+Show Affiliations

Unit of Laboratory Medicine, West China Second Hospital, Sichuan University, Chengdu, Sichuan, 610041 PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

19199249

Citation

Zhang, Juan, et al. "[The Pvu II and Xba I Polymorphisms in the Estrogen Receptor Alpha Gene in Chinese Patients With Severe Preeclampsia]." Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, vol. 26, no. 1, 2009, pp. 40-4.
Zhang J, Bai H, Liu XH, et al. [The Pvu II and Xba I polymorphisms in the estrogen receptor alpha gene in Chinese patients with severe preeclampsia]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009;26(1):40-4.
Zhang, J., Bai, H., Liu, X. H., Fan, P., Liu, R., & He, G. L. (2009). [The Pvu II and Xba I polymorphisms in the estrogen receptor alpha gene in Chinese patients with severe preeclampsia]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, 26(1), 40-4. https://doi.org/10.3760/cma.j.issn.1003-9406.2009.01.009
Zhang J, et al. [The Pvu II and Xba I Polymorphisms in the Estrogen Receptor Alpha Gene in Chinese Patients With Severe Preeclampsia]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009;26(1):40-4. PubMed PMID: 19199249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The Pvu II and Xba I polymorphisms in the estrogen receptor alpha gene in Chinese patients with severe preeclampsia]. AU - Zhang,Juan, AU - Bai,Huai, AU - Liu,Xing-hui, AU - Fan,Ping, AU - Liu,Rui, AU - He,Guo-lin, PY - 2009/2/10/entrez PY - 2009/2/10/pubmed PY - 2009/5/21/medline SP - 40 EP - 4 JF - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics JO - Zhonghua Yi Xue Yi Chuan Xue Za Zhi VL - 26 IS - 1 N2 - OBJECTIVE: To assess the allele and genotype frequencies of the estrogen receptor alpha (ESR alpha) Pvu II and Xba I polymorphisms in patients with severe preeclampsia and compare them with those of normal pregnant women. METHODS: Blood samples from 131 patients with severe preeclampsia and 223 normal pregnant women from Chinese Han in Chengdu area were analyzed, using PCR-RFLP method. Pregnant patients with blood pressure exceeding 140/90 mmHg (or 18.7/12 kPa) were recruited with a strict definition of preeclampsia. Genotyping was performed using PCR-RFLP for Pvu II and Xba I polymorphisms in the ESR alpha gene. RESULTS: The T and C allele frequencies for Pvu II site were 0.580 and 0.420 in the patient group, and 0.576 and 0.424 in the controls, respectively. The A and G allele frequencies for Xba I site were 0.763 and 0.237 in the patient group, and 0.807 and 0.193 in control group, respectively. No significant difference in the allele frequencies of either site was observed between the two groups. However, the CC homozygotes or CT heterozygotes in the control pregnant women had higher systolic blood pressure levels than TT homozygotes for Pvu II site after the data was adjusted for age and BMI (114.00+/-21.44 mmHg or 114.33+/-1.21 mmHg vs. 108.62+/-1.91 mmHg, P<0.05). No genotype effect on the blood pressures was found for Pvu II site in the case group, nor for Xba I site in either group. CONCLUSION: Our work has excluded the association of the ESRalpha Pvu II and Xb I polymorphism with severe preeclampsia in a Southwest Chinese population, although this polymorphism may be associated with the systolic blood pressure level in the normal pregnant women. SN - 1003-9406 UR - https://www.unboundmedicine.com/medline/citation/19199249/[The_Pvu_II_and_Xba_I_polymorphisms_in_the_estrogen_receptor_alpha_gene_in_Chinese_patients_with_severe_preeclampsia]_ L2 - http://www.diseaseinfosearch.org/result/5920 DB - PRIME DP - Unbound Medicine ER -