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Alleles and haplotypes of the estrogen receptor alpha gene are associated with an increased risk of spontaneous abortion.
Fertil Steril. 2010 Apr; 93(6):1809-15.FS

Abstract

OBJECTIVE

To investigate whether polymorphisms in estrogen receptor alpha (ERalpha) or beta (ERbeta) genes are associated with a risk of miscarriage.

DESIGN

A retrospectively analyzed, prospectively obtained database of cases and controls.

SETTING

University hospital menopause unit.

PATIENT(S)

177 women with at least one spontaneous abortion and 442 controls with at least one live birth and no history of miscarriage.

INTERVENTION(S)

None.

MAIN OUTCOME MEASURE(S)

Genotype frequencies and odd ratios for abortion risk in cases and controls for four single nucleotide polymorphisms (SNPs) located in intron 1 (C>T and A>G), intron 4 (A>T), and exon 8 (T>C) for the ERalpha gene, and two SNPs located in intron 2 (C>T) and intron 8 (G>A) for the ERbeta gene.

RESULT(S)

A statistically significant association was found between spontaneous abortion and SNPs rs2234693 (C>T, defined by restriction enzyme PvuII) and rs9340799 (A>G, defined by restriction enzyme XbaI) in intron 1 of the ERalpha gene. The age-adjusted odds ratio for abortion risk was 1.29 for the TA haplotype (defined by PvuII-XbaI) with respect to the CG haplotype in women with at least one abortion, which increased to 1.9 in women with two or more abortions.

CONCLUSION(S)

The TA haplotype defined by PvuII and XbaI was associated with an increased risk of reproductive loss. No association was found for the ERbeta gene.

Authors+Show Affiliations

Research Foundation, Hospital Clínico Universitario, Valencia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19200973

Citation

Pineda, Begoña, et al. "Alleles and Haplotypes of the Estrogen Receptor Alpha Gene Are Associated With an Increased Risk of Spontaneous Abortion." Fertility and Sterility, vol. 93, no. 6, 2010, pp. 1809-15.
Pineda B, Hermenegildo C, Tarín JJ, et al. Alleles and haplotypes of the estrogen receptor alpha gene are associated with an increased risk of spontaneous abortion. Fertil Steril. 2010;93(6):1809-15.
Pineda, B., Hermenegildo, C., Tarín, J. J., Laporta, P., Cano, A., & García-Pérez, M. A. (2010). Alleles and haplotypes of the estrogen receptor alpha gene are associated with an increased risk of spontaneous abortion. Fertility and Sterility, 93(6), 1809-15. https://doi.org/10.1016/j.fertnstert.2008.12.086
Pineda B, et al. Alleles and Haplotypes of the Estrogen Receptor Alpha Gene Are Associated With an Increased Risk of Spontaneous Abortion. Fertil Steril. 2010;93(6):1809-15. PubMed PMID: 19200973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alleles and haplotypes of the estrogen receptor alpha gene are associated with an increased risk of spontaneous abortion. AU - Pineda,Begoña, AU - Hermenegildo,Carlos, AU - Tarín,Juan J, AU - Laporta,Paz, AU - Cano,Antonio, AU - García-Pérez,Miguel Angel, Y1 - 2009/02/06/ PY - 2008/09/25/received PY - 2008/12/12/revised PY - 2008/12/16/accepted PY - 2009/2/10/entrez PY - 2009/2/10/pubmed PY - 2010/4/17/medline SP - 1809 EP - 15 JF - Fertility and sterility JO - Fertil Steril VL - 93 IS - 6 N2 - OBJECTIVE: To investigate whether polymorphisms in estrogen receptor alpha (ERalpha) or beta (ERbeta) genes are associated with a risk of miscarriage. DESIGN: A retrospectively analyzed, prospectively obtained database of cases and controls. SETTING: University hospital menopause unit. PATIENT(S): 177 women with at least one spontaneous abortion and 442 controls with at least one live birth and no history of miscarriage. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Genotype frequencies and odd ratios for abortion risk in cases and controls for four single nucleotide polymorphisms (SNPs) located in intron 1 (C>T and A>G), intron 4 (A>T), and exon 8 (T>C) for the ERalpha gene, and two SNPs located in intron 2 (C>T) and intron 8 (G>A) for the ERbeta gene. RESULT(S): A statistically significant association was found between spontaneous abortion and SNPs rs2234693 (C>T, defined by restriction enzyme PvuII) and rs9340799 (A>G, defined by restriction enzyme XbaI) in intron 1 of the ERalpha gene. The age-adjusted odds ratio for abortion risk was 1.29 for the TA haplotype (defined by PvuII-XbaI) with respect to the CG haplotype in women with at least one abortion, which increased to 1.9 in women with two or more abortions. CONCLUSION(S): The TA haplotype defined by PvuII and XbaI was associated with an increased risk of reproductive loss. No association was found for the ERbeta gene. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/19200973/Alleles_and_haplotypes_of_the_estrogen_receptor_alpha_gene_are_associated_with_an_increased_risk_of_spontaneous_abortion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(08)04775-4 DB - PRIME DP - Unbound Medicine ER -