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Field effectiveness of pyrantel and failure of Parascaris equorum egg count reduction following ivermectin treatment in Italian horse farms.
Vet Parasitol. 2009 Apr 06; 161(1-2):138-41.VP

Abstract

A study was carried out to assess the field efficacy of ivermectin (IVM) and pyrantel pamoate (PYR) against Parascaris equorum. Seventy-three foals (3-18 months old) from 5 stud farms, not treated with anthelmintics in the previous 10 weeks and with individual faecal egg counts (FEC) >200, were included in the study. For each stud farm, 5-7 foals were included in the IVM-treatment group (IVM 0.2%, 200 mcg/kg body weight) or in the PYR-treatment group (PYR 38%, 13.2mg/kg body weight) and 3 were untreated as controls. For each foal, FECs were carried out before treatment (Day 0) and on Days 7 and 21. An individually based estimation of efficacy was assessed by a bootstrap simulation applied to different previously suggested formulae to evaluate the percent reduction of faecal egg counts (FECR). Two thousand bootstrap resamples were constructed from individual FECRs and the parasite population was considered susceptible for FECs >or=90 and 95% confidence interval (C.I.) >or=95%, suspected resistant for FECRs comprised between 80 and 90% and 95% C.I. <95% and resistant when FECR <or=80 and 95% C.I. <or=90%. IVM treatment was effective in foals from 2 farms, was equivocal at both study times in 1 farm and ineffective in 2 farms, while PYR was fully effective on all farms. This data shows that P. equorum-resistant populations are present also in Italy and the phenomenon is spreading in horses throughout Europe.

Authors+Show Affiliations

Dip. di Scienze Biopatologiche ed Igiene delle Produzioni Animali e Alimentari, Sez. di Parassitologia, Università degli Studi di Perugia, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

19201100

Citation

Veronesi, Fabrizia, et al. "Field Effectiveness of Pyrantel and Failure of Parascaris Equorum Egg Count Reduction Following Ivermectin Treatment in Italian Horse Farms." Veterinary Parasitology, vol. 161, no. 1-2, 2009, pp. 138-41.
Veronesi F, Moretta I, Moretti A, et al. Field effectiveness of pyrantel and failure of Parascaris equorum egg count reduction following ivermectin treatment in Italian horse farms. Vet Parasitol. 2009;161(1-2):138-41.
Veronesi, F., Moretta, I., Moretti, A., Fioretti, D. P., & Genchi, C. (2009). Field effectiveness of pyrantel and failure of Parascaris equorum egg count reduction following ivermectin treatment in Italian horse farms. Veterinary Parasitology, 161(1-2), 138-41. https://doi.org/10.1016/j.vetpar.2009.01.004
Veronesi F, et al. Field Effectiveness of Pyrantel and Failure of Parascaris Equorum Egg Count Reduction Following Ivermectin Treatment in Italian Horse Farms. Vet Parasitol. 2009 Apr 6;161(1-2):138-41. PubMed PMID: 19201100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Field effectiveness of pyrantel and failure of Parascaris equorum egg count reduction following ivermectin treatment in Italian horse farms. AU - Veronesi,Fabrizia, AU - Moretta,Iolanda, AU - Moretti,Annabella, AU - Fioretti,Daniela Piergili, AU - Genchi,Claudio, Y1 - 2009/01/20/ PY - 2008/10/09/received PY - 2009/01/07/revised PY - 2009/01/09/accepted PY - 2009/2/10/entrez PY - 2009/2/10/pubmed PY - 2009/6/3/medline SP - 138 EP - 41 JF - Veterinary parasitology JO - Vet Parasitol VL - 161 IS - 1-2 N2 - A study was carried out to assess the field efficacy of ivermectin (IVM) and pyrantel pamoate (PYR) against Parascaris equorum. Seventy-three foals (3-18 months old) from 5 stud farms, not treated with anthelmintics in the previous 10 weeks and with individual faecal egg counts (FEC) >200, were included in the study. For each stud farm, 5-7 foals were included in the IVM-treatment group (IVM 0.2%, 200 mcg/kg body weight) or in the PYR-treatment group (PYR 38%, 13.2mg/kg body weight) and 3 were untreated as controls. For each foal, FECs were carried out before treatment (Day 0) and on Days 7 and 21. An individually based estimation of efficacy was assessed by a bootstrap simulation applied to different previously suggested formulae to evaluate the percent reduction of faecal egg counts (FECR). Two thousand bootstrap resamples were constructed from individual FECRs and the parasite population was considered susceptible for FECs >or=90 and 95% confidence interval (C.I.) >or=95%, suspected resistant for FECRs comprised between 80 and 90% and 95% C.I. <95% and resistant when FECR <or=80 and 95% C.I. <or=90%. IVM treatment was effective in foals from 2 farms, was equivocal at both study times in 1 farm and ineffective in 2 farms, while PYR was fully effective on all farms. This data shows that P. equorum-resistant populations are present also in Italy and the phenomenon is spreading in horses throughout Europe. SN - 0304-4017 UR - https://www.unboundmedicine.com/medline/citation/19201100/Field_effectiveness_of_pyrantel_and_failure_of_Parascaris_equorum_egg_count_reduction_following_ivermectin_treatment_in_Italian_horse_farms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-4017(09)00031-4 DB - PRIME DP - Unbound Medicine ER -