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The effect of simvastatin on coenzyme Q and antioxidant/oxidant balance in diabetic-hypercholesterolaemic rats.
Gen Physiol Biophys. 2008 Dec; 27(4):291-8.GP

Abstract

The effect of simvastatin administered for 10 days on coenzyme Q and antioxidant/oxidant balance in a rat model of diabetes mellitus and hypercholesterolaemia was studied. In the diabetic-hypercholesterolaemic rats the signs of oxidative stress-decreased alpha-tocopherol/cholesterol in the plasma (p < 0.01) and alpha-tocopherol in liver (p < 0.001) together with increased lipid peroxidation in the liver (TBARS, p < 0.05) were found. Increased coenzyme Q9 concentrations in the plasma (p < 0.05) and liver (p < 0.01), coenzyme Q10 in the myocardium (p < 0.05) and in the liver (p < 0.01) may indicate adaptation to oxidative stress. Administration of simvastatin (10 mg/kg) to the diabetic-hypercholesterolaemic rats counteracted increased myocardial (coenzyme Q10, p < 0.05) and liver (total coenzyme Q9, p < 0.05) coenzyme Q concentrations but did not improve alpha-tocopherol depletion and increased formation of TBARS in the liver. Even though simvastatin treatment did not induce coenzyme Q deficiency in plasma, heart and liver of the diabetic-hypercholesterolaemic rats as compared to the control levels, it was not able to prevent completely the changes in antioxidant/oxidant balance induced by diabetes and hypercholesterolaemia. The results highlight the importance of studying the effect of statins on the coenzyme Q levels in the animal models of pathological conditions known to change the initial antioxidant defence system.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32 Bratislava, Slovakia. kuzelova@fpharm.uniba.skNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19202203

Citation

Kuzelová, Magdaléna, et al. "The Effect of Simvastatin On Coenzyme Q and Antioxidant/oxidant Balance in Diabetic-hypercholesterolaemic Rats." General Physiology and Biophysics, vol. 27, no. 4, 2008, pp. 291-8.
Kuzelová M, Adameová A, Sumbalová Z, et al. The effect of simvastatin on coenzyme Q and antioxidant/oxidant balance in diabetic-hypercholesterolaemic rats. Gen Physiol Biophys. 2008;27(4):291-8.
Kuzelová, M., Adameová, A., Sumbalová, Z., Paulíková, I., Harcárová, A., Svec, P., & Kucharská, J. (2008). The effect of simvastatin on coenzyme Q and antioxidant/oxidant balance in diabetic-hypercholesterolaemic rats. General Physiology and Biophysics, 27(4), 291-8.
Kuzelová M, et al. The Effect of Simvastatin On Coenzyme Q and Antioxidant/oxidant Balance in Diabetic-hypercholesterolaemic Rats. Gen Physiol Biophys. 2008;27(4):291-8. PubMed PMID: 19202203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of simvastatin on coenzyme Q and antioxidant/oxidant balance in diabetic-hypercholesterolaemic rats. AU - Kuzelová,Magdaléna, AU - Adameová,Adriana, AU - Sumbalová,Zuzana, AU - Paulíková,Ingrid, AU - Harcárová,Anna, AU - Svec,Pavel, AU - Kucharská,Jarmila, PY - 2009/2/10/entrez PY - 2009/2/10/pubmed PY - 2009/5/5/medline SP - 291 EP - 8 JF - General physiology and biophysics JO - Gen Physiol Biophys VL - 27 IS - 4 N2 - The effect of simvastatin administered for 10 days on coenzyme Q and antioxidant/oxidant balance in a rat model of diabetes mellitus and hypercholesterolaemia was studied. In the diabetic-hypercholesterolaemic rats the signs of oxidative stress-decreased alpha-tocopherol/cholesterol in the plasma (p < 0.01) and alpha-tocopherol in liver (p < 0.001) together with increased lipid peroxidation in the liver (TBARS, p < 0.05) were found. Increased coenzyme Q9 concentrations in the plasma (p < 0.05) and liver (p < 0.01), coenzyme Q10 in the myocardium (p < 0.05) and in the liver (p < 0.01) may indicate adaptation to oxidative stress. Administration of simvastatin (10 mg/kg) to the diabetic-hypercholesterolaemic rats counteracted increased myocardial (coenzyme Q10, p < 0.05) and liver (total coenzyme Q9, p < 0.05) coenzyme Q concentrations but did not improve alpha-tocopherol depletion and increased formation of TBARS in the liver. Even though simvastatin treatment did not induce coenzyme Q deficiency in plasma, heart and liver of the diabetic-hypercholesterolaemic rats as compared to the control levels, it was not able to prevent completely the changes in antioxidant/oxidant balance induced by diabetes and hypercholesterolaemia. The results highlight the importance of studying the effect of statins on the coenzyme Q levels in the animal models of pathological conditions known to change the initial antioxidant defence system. SN - 0231-5882 UR - https://www.unboundmedicine.com/medline/citation/19202203/The_effect_of_simvastatin_on_coenzyme_Q_and_antioxidant/oxidant_balance_in_diabetic_hypercholesterolaemic_rats_ DB - PRIME DP - Unbound Medicine ER -