Tags

Type your tag names separated by a space and hit enter

Evaluation of macrocytosis.
Am Fam Physician 2009; 79(3):203-8AF

Abstract

Macrocytosis, generally defined as a mean corpuscular volume greater than 100 fL, is frequently encountered when a complete blood count is performed. The most common etiologies are alcoholism, vitamin B12 and folate deficiencies, and medications. History and physical examination, vitamin B12 level, reticulocyte count, and a peripheral smear are helpful in delineating the underlying cause of macrocytosis. When the peripheral smear indicates megaloblastic anemia (demonstrated by macro-ovalocytes and hyper-segmented neutrophils), vitamin B12 or folate deficiency is the most likely cause. When the peripheral smear is non-megaloblastic, the reticulocyte count helps differentiate between drug or alcohol toxicity and hemolysis or hemorrhage. Of other possible etiologies, hypothyroidism, liver disease, and primary bone marrow dysplasias (including myelodysplasia and myeloproliferative disorders) are some of the more common causes.

Authors+Show Affiliations

Department of Family Medicine, University of Michigan, Ann Arbor, Michigan, USA. jkaferle@umich.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19202968

Citation

Kaferle, Joyce, and Cheryl E. Strzoda. "Evaluation of Macrocytosis." American Family Physician, vol. 79, no. 3, 2009, pp. 203-8.
Kaferle J, Strzoda CE. Evaluation of macrocytosis. Am Fam Physician. 2009;79(3):203-8.
Kaferle, J., & Strzoda, C. E. (2009). Evaluation of macrocytosis. American Family Physician, 79(3), pp. 203-8.
Kaferle J, Strzoda CE. Evaluation of Macrocytosis. Am Fam Physician. 2009 Feb 1;79(3):203-8. PubMed PMID: 19202968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of macrocytosis. AU - Kaferle,Joyce, AU - Strzoda,Cheryl E, PY - 2009/2/11/entrez PY - 2009/2/11/pubmed PY - 2009/2/28/medline SP - 203 EP - 8 JF - American family physician JO - Am Fam Physician VL - 79 IS - 3 N2 - Macrocytosis, generally defined as a mean corpuscular volume greater than 100 fL, is frequently encountered when a complete blood count is performed. The most common etiologies are alcoholism, vitamin B12 and folate deficiencies, and medications. History and physical examination, vitamin B12 level, reticulocyte count, and a peripheral smear are helpful in delineating the underlying cause of macrocytosis. When the peripheral smear indicates megaloblastic anemia (demonstrated by macro-ovalocytes and hyper-segmented neutrophils), vitamin B12 or folate deficiency is the most likely cause. When the peripheral smear is non-megaloblastic, the reticulocyte count helps differentiate between drug or alcohol toxicity and hemolysis or hemorrhage. Of other possible etiologies, hypothyroidism, liver disease, and primary bone marrow dysplasias (including myelodysplasia and myeloproliferative disorders) are some of the more common causes. SN - 0002-838X UR - https://www.unboundmedicine.com/medline/citation/19202968/Evaluation_of_macrocytosis_ L2 - http://www.aafp.org/link_out?pmid=19202968 DB - PRIME DP - Unbound Medicine ER -