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Sleep disturbances and serum ferritin levels in children with attention-deficit/hyperactivity disorder.
Eur Child Adolesc Psychiatry 2009; 18(7):393-9EC

Abstract

BACKGROUND

A subset of children with attention-deficit/hyperactivity disorder (ADHD) may present with impairing sleep disturbances. While preliminary evidence suggests that iron deficiency might be involved into the pathophysiology of daytime ADHD symptoms, no research has been conducted to explore the relationship between iron deficiency and sleep disturbances in patients with ADHD. The aim of this study was to assess the association between serum ferritin levels and parent reports of sleep disturbances in a sample of children with ADHD.

MEASURES

parents filled out the Sleep Disturbance Scale for Children (SDSC) and the Conners Parent Rating Scale (CPRS). Serum ferritin levels were determined using the Tinaquant method.

RESULTS

Compared to children with serum ferritin levels >or=45 microg/l, those with serum ferritin levels <45 microg/l had significantly higher scores on the SDSC subscale "Sleep wake transition disorders" (SWTD) (P = 0.042), which includes items on abnormal movements in sleep, as well as significantly higher scores on the CPRS-ADHD index (P = 0.034). The mean scores on the other SDSC subscales did not significantly differ between children with serum ferritin >or=45 and <45 microg/l. Serum ferritin levels were inversely correlated to SWTD scores (P = 0.043).

CONCLUSION

Serum ferritin levels <45 microg/l might indicate a risk for sleep wake transition disorders, including abnormal sleep movements, in children with ADHD. Our results based on questionnaires set the basis for further actigraphic and polysomnographic studies on nighttime activity and iron deficiency in ADHD. Research in this field may suggest future trials of iron supplementation (possibly in association with ADHD medications) for abnormal sleep motor activity in children with ADHD.

Authors+Show Affiliations

AP-HP, Child and Adolescent Psychopathology Unit, Robert Debré Hospital, Paris VII University, Paris, France. samuele.cortese@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19205783

Citation

Cortese, Samuele, et al. "Sleep Disturbances and Serum Ferritin Levels in Children With Attention-deficit/hyperactivity Disorder." European Child & Adolescent Psychiatry, vol. 18, no. 7, 2009, pp. 393-9.
Cortese S, Konofal E, Bernardina BD, et al. Sleep disturbances and serum ferritin levels in children with attention-deficit/hyperactivity disorder. Eur Child Adolesc Psychiatry. 2009;18(7):393-9.
Cortese, S., Konofal, E., Bernardina, B. D., Mouren, M. C., & Lecendreux, M. (2009). Sleep disturbances and serum ferritin levels in children with attention-deficit/hyperactivity disorder. European Child & Adolescent Psychiatry, 18(7), pp. 393-9. doi:10.1007/s00787-009-0746-8.
Cortese S, et al. Sleep Disturbances and Serum Ferritin Levels in Children With Attention-deficit/hyperactivity Disorder. Eur Child Adolesc Psychiatry. 2009;18(7):393-9. PubMed PMID: 19205783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sleep disturbances and serum ferritin levels in children with attention-deficit/hyperactivity disorder. AU - Cortese,Samuele, AU - Konofal,Eric, AU - Bernardina,Bernardo Dalla, AU - Mouren,Marie-Christine, AU - Lecendreux,Michel, Y1 - 2009/02/05/ PY - 2008/03/16/received PY - 2008/11/24/accepted PY - 2009/2/12/entrez PY - 2009/2/12/pubmed PY - 2009/9/22/medline SP - 393 EP - 9 JF - European child & adolescent psychiatry JO - Eur Child Adolesc Psychiatry VL - 18 IS - 7 N2 - BACKGROUND: A subset of children with attention-deficit/hyperactivity disorder (ADHD) may present with impairing sleep disturbances. While preliminary evidence suggests that iron deficiency might be involved into the pathophysiology of daytime ADHD symptoms, no research has been conducted to explore the relationship between iron deficiency and sleep disturbances in patients with ADHD. The aim of this study was to assess the association between serum ferritin levels and parent reports of sleep disturbances in a sample of children with ADHD. MEASURES: parents filled out the Sleep Disturbance Scale for Children (SDSC) and the Conners Parent Rating Scale (CPRS). Serum ferritin levels were determined using the Tinaquant method. RESULTS: Compared to children with serum ferritin levels >or=45 microg/l, those with serum ferritin levels <45 microg/l had significantly higher scores on the SDSC subscale "Sleep wake transition disorders" (SWTD) (P = 0.042), which includes items on abnormal movements in sleep, as well as significantly higher scores on the CPRS-ADHD index (P = 0.034). The mean scores on the other SDSC subscales did not significantly differ between children with serum ferritin >or=45 and <45 microg/l. Serum ferritin levels were inversely correlated to SWTD scores (P = 0.043). CONCLUSION: Serum ferritin levels <45 microg/l might indicate a risk for sleep wake transition disorders, including abnormal sleep movements, in children with ADHD. Our results based on questionnaires set the basis for further actigraphic and polysomnographic studies on nighttime activity and iron deficiency in ADHD. Research in this field may suggest future trials of iron supplementation (possibly in association with ADHD medications) for abnormal sleep motor activity in children with ADHD. SN - 1435-165X UR - https://www.unboundmedicine.com/medline/citation/19205783/Sleep_disturbances_and_serum_ferritin_levels_in_children_with_attention_deficit/hyperactivity_disorder_ L2 - https://dx.doi.org/10.1007/s00787-009-0746-8 DB - PRIME DP - Unbound Medicine ER -