Tags

Type your tag names separated by a space and hit enter

Mitochondria as targets for chemotherapy.
Apoptosis. 2009 Apr; 14(4):624-40.A

Abstract

Mitochondrial malfunctioning is implicated in the pathogenesis of a variety of disorders, including cancer and multiple neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, and Huntington's disease. Disturbance of mitochondrial vital functions, e.g., production of ATP, calcium buffering capacity, and generation of reactive oxygen species, can be potentially involved in disease pathogenesis. Neurological disorders caused by mitochondrial deterioration are often associated with cell loss within specific brain regions. In contrast, mitochondrial alterations in tumor cells and the "Warburg effect" might lead to cell survival and resistance of tumor cells to chemotherapy. This review is devoted to the role of mitochondria in neurodegeneration and tumor formation, and describes how targeting of mitochondria can be beneficial in the therapy of these diseases, which affect a large human population.

Authors+Show Affiliations

Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Vladimir.Gogvadze@ki.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19205885

Citation

Gogvadze, Vladimir, et al. "Mitochondria as Targets for Chemotherapy." Apoptosis : an International Journal On Programmed Cell Death, vol. 14, no. 4, 2009, pp. 624-40.
Gogvadze V, Orrenius S, Zhivotovsky B. Mitochondria as targets for chemotherapy. Apoptosis. 2009;14(4):624-40.
Gogvadze, V., Orrenius, S., & Zhivotovsky, B. (2009). Mitochondria as targets for chemotherapy. Apoptosis : an International Journal On Programmed Cell Death, 14(4), 624-40. https://doi.org/10.1007/s10495-009-0323-0
Gogvadze V, Orrenius S, Zhivotovsky B. Mitochondria as Targets for Chemotherapy. Apoptosis. 2009;14(4):624-40. PubMed PMID: 19205885.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitochondria as targets for chemotherapy. AU - Gogvadze,Vladimir, AU - Orrenius,Sten, AU - Zhivotovsky,Boris, PY - 2009/2/12/entrez PY - 2009/2/12/pubmed PY - 2009/4/30/medline SP - 624 EP - 40 JF - Apoptosis : an international journal on programmed cell death JO - Apoptosis VL - 14 IS - 4 N2 - Mitochondrial malfunctioning is implicated in the pathogenesis of a variety of disorders, including cancer and multiple neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, and Huntington's disease. Disturbance of mitochondrial vital functions, e.g., production of ATP, calcium buffering capacity, and generation of reactive oxygen species, can be potentially involved in disease pathogenesis. Neurological disorders caused by mitochondrial deterioration are often associated with cell loss within specific brain regions. In contrast, mitochondrial alterations in tumor cells and the "Warburg effect" might lead to cell survival and resistance of tumor cells to chemotherapy. This review is devoted to the role of mitochondria in neurodegeneration and tumor formation, and describes how targeting of mitochondria can be beneficial in the therapy of these diseases, which affect a large human population. SN - 1573-675X UR - https://www.unboundmedicine.com/medline/citation/19205885/Mitochondria_as_targets_for_chemotherapy_ L2 - https://doi.org/10.1007/s10495-009-0323-0 DB - PRIME DP - Unbound Medicine ER -