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Fluid control in elderly patients with nocturia.
Int J Urol. 2009 Mar; 16(3):307-13.IJ

Abstract

OBJECTIVES

To investigate the pathophysiology of nocturnal polyuria associated with aging.

METHODS

Fifty patients (mean age 67.7 years, range 50-87) with nocturia were recruited for this prospective study. Patients were classified into nocturnal polyuria (NP) and non-nocturnal polyuria (non-NP) groups based on records of their frequency-volume charts. A hypertonic saline infusion test was carried out to evaluate individual osmotic and volume control.

RESULTS

In the NP group, there was a significantly increased nocturnal diuretic rate compared with the daytime diuretic rate. In the non-NP group, there was a significantly decreased nocturnal diuretic rate compared with the daytime rate. There was also a positive correlation between systolic blood pressure and nocturnal diuretic rate, and a negative correlation between systolic blood pressure and daytime diuretic rate in those with NP, but no correlation in those without NP. Thus, a close relationship between diuretic rates and systolic blood pressure was seen in NP patients. Moreover, a slight overall shift upward from the physiological range of plasma osmolality relative to arginine vasopressin after hypertonic saline loading was seen in those with NP compared with those without. An altered circadian rhythm was also seen in diurnal plasma arginine vasopressin levels in patients with and without NP.

CONCLUSIONS

Patients with nocturnal polyuria are likely to have a more hypervolemic or vasoconstrictive condition. It is considered that non-osmotic control takes on a greater meaning in patients with nocturnal polyuria, though osmotic control contributes less to diuresis within the physiological plasma osmolality range with aging.

Authors+Show Affiliations

Department of Urology, Uda City Hospital, Uda, Nara, Japan. osnatsume@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19207113

Citation

Natsume, Osamu, et al. "Fluid Control in Elderly Patients With Nocturia." International Journal of Urology : Official Journal of the Japanese Urological Association, vol. 16, no. 3, 2009, pp. 307-13.
Natsume O, Kaneko Y, Hirayama A, et al. Fluid control in elderly patients with nocturia. Int J Urol. 2009;16(3):307-13.
Natsume, O., Kaneko, Y., Hirayama, A., Fujimoto, K., & Hirao, Y. (2009). Fluid control in elderly patients with nocturia. International Journal of Urology : Official Journal of the Japanese Urological Association, 16(3), 307-13. https://doi.org/10.1111/j.1442-2042.2008.02248.x
Natsume O, et al. Fluid Control in Elderly Patients With Nocturia. Int J Urol. 2009;16(3):307-13. PubMed PMID: 19207113.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fluid control in elderly patients with nocturia. AU - Natsume,Osamu, AU - Kaneko,Yoshiteru, AU - Hirayama,Akihide, AU - Fujimoto,Kiyohide, AU - Hirao,Yoshihiko, Y1 - 2009/02/04/ PY - 2009/2/12/entrez PY - 2009/2/12/pubmed PY - 2009/7/16/medline SP - 307 EP - 13 JF - International journal of urology : official journal of the Japanese Urological Association JO - Int. J. Urol. VL - 16 IS - 3 N2 - OBJECTIVES: To investigate the pathophysiology of nocturnal polyuria associated with aging. METHODS: Fifty patients (mean age 67.7 years, range 50-87) with nocturia were recruited for this prospective study. Patients were classified into nocturnal polyuria (NP) and non-nocturnal polyuria (non-NP) groups based on records of their frequency-volume charts. A hypertonic saline infusion test was carried out to evaluate individual osmotic and volume control. RESULTS: In the NP group, there was a significantly increased nocturnal diuretic rate compared with the daytime diuretic rate. In the non-NP group, there was a significantly decreased nocturnal diuretic rate compared with the daytime rate. There was also a positive correlation between systolic blood pressure and nocturnal diuretic rate, and a negative correlation between systolic blood pressure and daytime diuretic rate in those with NP, but no correlation in those without NP. Thus, a close relationship between diuretic rates and systolic blood pressure was seen in NP patients. Moreover, a slight overall shift upward from the physiological range of plasma osmolality relative to arginine vasopressin after hypertonic saline loading was seen in those with NP compared with those without. An altered circadian rhythm was also seen in diurnal plasma arginine vasopressin levels in patients with and without NP. CONCLUSIONS: Patients with nocturnal polyuria are likely to have a more hypervolemic or vasoconstrictive condition. It is considered that non-osmotic control takes on a greater meaning in patients with nocturnal polyuria, though osmotic control contributes less to diuresis within the physiological plasma osmolality range with aging. SN - 1442-2042 UR - https://www.unboundmedicine.com/medline/citation/19207113/Fluid_control_in_elderly_patients_with_nocturia_ L2 - https://doi.org/10.1111/j.1442-2042.2008.02248.x DB - PRIME DP - Unbound Medicine ER -