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Acute effects of nicotine on arterial stiffness and wave reflection in healthy young non-smokers.
Clin Exp Pharmacol Physiol. 2009 Aug; 36(8):784-9.CE

Abstract

1. Recently, we have demonstrated that cigarette smoke exposure proportionally increases plasma nicotine levels and arterial wave reflection to the aorta. However, the exact contribution of nicotine to the smoke-induced enhancement of wave reflection and the potential underlying mechanisms have not been fully investigated. 2. The present study was a prospective study in 15 healthy male non-smokers. All received a placebo and a 2 mg nicotine tablet, according to a randomized double-blind cross-over study design. Each subject underwent repeated measurements at baseline and for 1 h after nicotine or placebo intake, using carotid-femoral pulse wave velocity (PWV) to assess arterial compliance. Concurrently, aortic pressures and the augmentation index were evaluated using applanation tonometry. 3. Plasma nicotine concentrations achieved 1 h after intake of the nicotine tablet reached comparable levels to those achieved after 1 h exposure to passive smoke (3.6 +/- 0.4 vs 3.2 +/- 0.4 ng/mL, respectively; P = 0.4). 4. Nicotine enhanced arterial wave reflection to the aorta, as assessed by the augmentation index corrected for heart rate (4.2 +/- 1.3 vs-0.7 +/- 0.8% with placebo; P = 0.001). In addition, a progressive increase in carotid-femoral PWV was noted after nicotine administration (0.3 +/- 0.1 vs-0.02 +/- 0.1 m/s with placebo; P = 0.04). This remained significant even after adjustment for changes in mean blood pressure and heart rate (P = 0.01). 5. Plasma nicotine concentrations comparable to those achieved after exposure to passive smoke enhance arterial wave reflection to the aorta. This is accompanied by an increase in carotid-femoral PWV, denoting a deterioration of arterial compliance by nicotine.

Authors+Show Affiliations

Department of Cardiology, Erasme Hospital, Brussels, Belgium. adamopoulos1@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19207722

Citation

Adamopoulos, Dionysios, et al. "Acute Effects of Nicotine On Arterial Stiffness and Wave Reflection in Healthy Young Non-smokers." Clinical and Experimental Pharmacology & Physiology, vol. 36, no. 8, 2009, pp. 784-9.
Adamopoulos D, Argacha JF, Gujic M, et al. Acute effects of nicotine on arterial stiffness and wave reflection in healthy young non-smokers. Clin Exp Pharmacol Physiol. 2009;36(8):784-9.
Adamopoulos, D., Argacha, J. F., Gujic, M., Preumont, N., Degaute, J. P., & van de Borne, P. (2009). Acute effects of nicotine on arterial stiffness and wave reflection in healthy young non-smokers. Clinical and Experimental Pharmacology & Physiology, 36(8), 784-9. https://doi.org/10.1111/j.1440-1681.2009.05141.x
Adamopoulos D, et al. Acute Effects of Nicotine On Arterial Stiffness and Wave Reflection in Healthy Young Non-smokers. Clin Exp Pharmacol Physiol. 2009;36(8):784-9. PubMed PMID: 19207722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute effects of nicotine on arterial stiffness and wave reflection in healthy young non-smokers. AU - Adamopoulos,Dionysios, AU - Argacha,Jean-François, AU - Gujic,Marko, AU - Preumont,Nicolas, AU - Degaute,Jean-Paul, AU - van de Borne,Philippe, Y1 - 2009/01/17/ PY - 2009/2/12/entrez PY - 2009/2/12/pubmed PY - 2010/2/6/medline SP - 784 EP - 9 JF - Clinical and experimental pharmacology & physiology JO - Clin. Exp. Pharmacol. Physiol. VL - 36 IS - 8 N2 - 1. Recently, we have demonstrated that cigarette smoke exposure proportionally increases plasma nicotine levels and arterial wave reflection to the aorta. However, the exact contribution of nicotine to the smoke-induced enhancement of wave reflection and the potential underlying mechanisms have not been fully investigated. 2. The present study was a prospective study in 15 healthy male non-smokers. All received a placebo and a 2 mg nicotine tablet, according to a randomized double-blind cross-over study design. Each subject underwent repeated measurements at baseline and for 1 h after nicotine or placebo intake, using carotid-femoral pulse wave velocity (PWV) to assess arterial compliance. Concurrently, aortic pressures and the augmentation index were evaluated using applanation tonometry. 3. Plasma nicotine concentrations achieved 1 h after intake of the nicotine tablet reached comparable levels to those achieved after 1 h exposure to passive smoke (3.6 +/- 0.4 vs 3.2 +/- 0.4 ng/mL, respectively; P = 0.4). 4. Nicotine enhanced arterial wave reflection to the aorta, as assessed by the augmentation index corrected for heart rate (4.2 +/- 1.3 vs-0.7 +/- 0.8% with placebo; P = 0.001). In addition, a progressive increase in carotid-femoral PWV was noted after nicotine administration (0.3 +/- 0.1 vs-0.02 +/- 0.1 m/s with placebo; P = 0.04). This remained significant even after adjustment for changes in mean blood pressure and heart rate (P = 0.01). 5. Plasma nicotine concentrations comparable to those achieved after exposure to passive smoke enhance arterial wave reflection to the aorta. This is accompanied by an increase in carotid-femoral PWV, denoting a deterioration of arterial compliance by nicotine. SN - 1440-1681 UR - https://www.unboundmedicine.com/medline/citation/19207722/Acute_effects_of_nicotine_on_arterial_stiffness_and_wave_reflection_in_healthy_young_non_smokers_ L2 - https://doi.org/10.1111/j.1440-1681.2009.05141.x DB - PRIME DP - Unbound Medicine ER -