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Interleukin-18 in induced sputum: association with lung function in chronic obstructive pulmonary disease.
Respir Med. 2009 Jul; 103(7):1056-62.RM

Abstract

BACKGROUND

It has been shown that interleukin (IL)-18 levels in induced sputum are reduced in asthmatic and healthy smokers. However, in chronic obstructive pulmonary disease (COPD) patients, recent data show an overproduction in the lungs and increased serum levels of IL-18, suggesting that IL-18 may be involved in the pathogenesis of COPD.

METHOD

In order to assess the relation of IL-18 with pulmonary function and airway inflammation in COPD, IL-18, tumour necrosis factor-alpha, and IL-8 levels were measured by ELISA in sputum supernatants obtained from patients with bronchitis type COPD (n=28), and healthy subjects (18 smokers and 17 non-smokers). Cellular localization of IL-18 was assessed by immunocytochemistry.

RESULTS

The levels of IL-18 were significantly higher in sputum supernatants of COPD patients compared to healthy smokers and non-smokers (p<0.05). IL-18 production was localized to sputum macrophages. IL-18 levels were inversely correlated with FEV(1) (% predicted) (r=-0.572, p=0.002) and FEV(1)/FVC ratio in COPD smokers (r=-0.608, p=0.001). No correlations were found between IL-18 levels and inflammatory markers studied in induced sputum obtained from COPD patients, healthy smokers and non-smokers.

CONCLUSION

In patients with COPD, increased levels of IL-18 in induced sputum were associated with airflow limitation, suggesting that IL-18 may be implicated in the pathogenesis of COPD.

Authors+Show Affiliations

Department of Respiratory Medicine, Medical School, University of Athens, Sotiria Hospital for Diseases of Chest, 152 Mesogion Avenue, Athens GR-11527, Greece. krovina@med.uoa.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19208460

Citation

Rovina, Nikoletta, et al. "Interleukin-18 in Induced Sputum: Association With Lung Function in Chronic Obstructive Pulmonary Disease." Respiratory Medicine, vol. 103, no. 7, 2009, pp. 1056-62.
Rovina N, Dima E, Gerassimou C, et al. Interleukin-18 in induced sputum: association with lung function in chronic obstructive pulmonary disease. Respir Med. 2009;103(7):1056-62.
Rovina, N., Dima, E., Gerassimou, C., Kollintza, A., Gratziou, C., & Roussos, C. (2009). Interleukin-18 in induced sputum: association with lung function in chronic obstructive pulmonary disease. Respiratory Medicine, 103(7), 1056-62. https://doi.org/10.1016/j.rmed.2009.01.011
Rovina N, et al. Interleukin-18 in Induced Sputum: Association With Lung Function in Chronic Obstructive Pulmonary Disease. Respir Med. 2009;103(7):1056-62. PubMed PMID: 19208460.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interleukin-18 in induced sputum: association with lung function in chronic obstructive pulmonary disease. AU - Rovina,Nikoletta, AU - Dima,Efrossini, AU - Gerassimou,Christina, AU - Kollintza,Androniki, AU - Gratziou,Christina, AU - Roussos,Charis, Y1 - 2009/02/08/ PY - 2008/11/23/received PY - 2009/01/09/revised PY - 2009/01/14/accepted PY - 2009/2/12/entrez PY - 2009/2/12/pubmed PY - 2010/7/10/medline SP - 1056 EP - 62 JF - Respiratory medicine JO - Respir Med VL - 103 IS - 7 N2 - BACKGROUND: It has been shown that interleukin (IL)-18 levels in induced sputum are reduced in asthmatic and healthy smokers. However, in chronic obstructive pulmonary disease (COPD) patients, recent data show an overproduction in the lungs and increased serum levels of IL-18, suggesting that IL-18 may be involved in the pathogenesis of COPD. METHOD: In order to assess the relation of IL-18 with pulmonary function and airway inflammation in COPD, IL-18, tumour necrosis factor-alpha, and IL-8 levels were measured by ELISA in sputum supernatants obtained from patients with bronchitis type COPD (n=28), and healthy subjects (18 smokers and 17 non-smokers). Cellular localization of IL-18 was assessed by immunocytochemistry. RESULTS: The levels of IL-18 were significantly higher in sputum supernatants of COPD patients compared to healthy smokers and non-smokers (p<0.05). IL-18 production was localized to sputum macrophages. IL-18 levels were inversely correlated with FEV(1) (% predicted) (r=-0.572, p=0.002) and FEV(1)/FVC ratio in COPD smokers (r=-0.608, p=0.001). No correlations were found between IL-18 levels and inflammatory markers studied in induced sputum obtained from COPD patients, healthy smokers and non-smokers. CONCLUSION: In patients with COPD, increased levels of IL-18 in induced sputum were associated with airflow limitation, suggesting that IL-18 may be implicated in the pathogenesis of COPD. SN - 1532-3064 UR - https://www.unboundmedicine.com/medline/citation/19208460/Interleukin_18_in_induced_sputum:_association_with_lung_function_in_chronic_obstructive_pulmonary_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(09)00027-4 DB - PRIME DP - Unbound Medicine ER -