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Quantitative assessment of optic nerve head morphology and retinal nerve fibre layer in non-arteritic anterior ischaemic optic neuropathy with optical coherence tomography and confocal scanning laser ophthalmoloscopy.
Br J Ophthalmol. 2009 Jun; 93(6):731-5.BJ

Abstract

BACKGROUND/AIMS

To compare the optic disc parameters between patients with non-arteritic anterior ischaemic optic neuropathy (NAION) and normal controls, using optical coherence tomography (OCT) and Heidelberg Retinal Tomograph III (HRT), and to evaluate the structure-function relationship in NAION eyes.

METHODS

Both eyes of 22 patients with typical unilateral NAION of > or =6 months' duration and 52 eyes from 52 randomly selected normal subjects underwent Humphrey visual field (HVF) examination and measurement of optic disc and retinal nerve fibre layer thickness (RNFLT).

RESULTS

For the NAION-affected eyes, NAION fellow eyes and normal controls, the ocular magnification-corrected OCT disc areas were respectively 1.849 (SD 0.343) mm(2), 1.809 (0.285) mm(2) and 1.964 (0.386) mm(2); the cup areas were 0.246 (0.187) mm(2), 0.172 (0.180) mm(2) and 0.469 (0.332) mm(2). On HRT, the disc areas were 2.11 (0.38) mm(2), 2.06 (0.40) mm(2) and 2.16 (0.42) mm(2); and the cup areas were 0.28 (0.34) mm(2), 0.25 (0.18) mm(2) and 0.48 (0.32) mm(2). On both OCT and HRT, the cup areas and cup-disc area ratios (CDAR) of both eyes of NAION patients were significantly smaller than controls (p< or =0.01), but the disc areas were not (p> or =0.21). There was a significant correlation between HVF mean deviation and OCT RNFLT (r = 0.44, p = 0.04) but not with HRT RNFLT (p = 0.30) in NAION-affected eyes.

CONCLUSION

NAION patients have smaller optic cups and CDARs in both eyes compared with controls. A larger sample size is necessary to demonstrate if disc size affects the risk of developing NAION. The NAION-affected eyes' OCT RNFLT correlated with HVF mean deviation but the HRT RNFLT did not.

Authors+Show Affiliations

Department of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong. kmcc2001@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19211599

Citation

Chan, C K M., et al. "Quantitative Assessment of Optic Nerve Head Morphology and Retinal Nerve Fibre Layer in Non-arteritic Anterior Ischaemic Optic Neuropathy With Optical Coherence Tomography and Confocal Scanning Laser Ophthalmoloscopy." The British Journal of Ophthalmology, vol. 93, no. 6, 2009, pp. 731-5.
Chan CK, Cheng AC, Leung CK, et al. Quantitative assessment of optic nerve head morphology and retinal nerve fibre layer in non-arteritic anterior ischaemic optic neuropathy with optical coherence tomography and confocal scanning laser ophthalmoloscopy. Br J Ophthalmol. 2009;93(6):731-5.
Chan, C. K., Cheng, A. C., Leung, C. K., Cheung, C. Y., Yung, A. Y., Gong, B., & Lam, D. S. (2009). Quantitative assessment of optic nerve head morphology and retinal nerve fibre layer in non-arteritic anterior ischaemic optic neuropathy with optical coherence tomography and confocal scanning laser ophthalmoloscopy. The British Journal of Ophthalmology, 93(6), 731-5. https://doi.org/10.1136/bjo.2008.143297
Chan CK, et al. Quantitative Assessment of Optic Nerve Head Morphology and Retinal Nerve Fibre Layer in Non-arteritic Anterior Ischaemic Optic Neuropathy With Optical Coherence Tomography and Confocal Scanning Laser Ophthalmoloscopy. Br J Ophthalmol. 2009;93(6):731-5. PubMed PMID: 19211599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitative assessment of optic nerve head morphology and retinal nerve fibre layer in non-arteritic anterior ischaemic optic neuropathy with optical coherence tomography and confocal scanning laser ophthalmoloscopy. AU - Chan,C K M, AU - Cheng,A C O, AU - Leung,C K S, AU - Cheung,C Y L, AU - Yung,A Y, AU - Gong,B, AU - Lam,D S C, Y1 - 2009/02/11/ PY - 2009/2/13/entrez PY - 2009/2/13/pubmed PY - 2009/6/20/medline SP - 731 EP - 5 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 93 IS - 6 N2 - BACKGROUND/AIMS: To compare the optic disc parameters between patients with non-arteritic anterior ischaemic optic neuropathy (NAION) and normal controls, using optical coherence tomography (OCT) and Heidelberg Retinal Tomograph III (HRT), and to evaluate the structure-function relationship in NAION eyes. METHODS: Both eyes of 22 patients with typical unilateral NAION of > or =6 months' duration and 52 eyes from 52 randomly selected normal subjects underwent Humphrey visual field (HVF) examination and measurement of optic disc and retinal nerve fibre layer thickness (RNFLT). RESULTS: For the NAION-affected eyes, NAION fellow eyes and normal controls, the ocular magnification-corrected OCT disc areas were respectively 1.849 (SD 0.343) mm(2), 1.809 (0.285) mm(2) and 1.964 (0.386) mm(2); the cup areas were 0.246 (0.187) mm(2), 0.172 (0.180) mm(2) and 0.469 (0.332) mm(2). On HRT, the disc areas were 2.11 (0.38) mm(2), 2.06 (0.40) mm(2) and 2.16 (0.42) mm(2); and the cup areas were 0.28 (0.34) mm(2), 0.25 (0.18) mm(2) and 0.48 (0.32) mm(2). On both OCT and HRT, the cup areas and cup-disc area ratios (CDAR) of both eyes of NAION patients were significantly smaller than controls (p< or =0.01), but the disc areas were not (p> or =0.21). There was a significant correlation between HVF mean deviation and OCT RNFLT (r = 0.44, p = 0.04) but not with HRT RNFLT (p = 0.30) in NAION-affected eyes. CONCLUSION: NAION patients have smaller optic cups and CDARs in both eyes compared with controls. A larger sample size is necessary to demonstrate if disc size affects the risk of developing NAION. The NAION-affected eyes' OCT RNFLT correlated with HVF mean deviation but the HRT RNFLT did not. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/19211599/Quantitative_assessment_of_optic_nerve_head_morphology_and_retinal_nerve_fibre_layer_in_non_arteritic_anterior_ischaemic_optic_neuropathy_with_optical_coherence_tomography_and_confocal_scanning_laser_ophthalmoloscopy_ L2 - https://bjo.bmj.com/lookup/pmidlookup?view=long&amp;pmid=19211599 DB - PRIME DP - Unbound Medicine ER -