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Hyperreninemia characterizing women with polycystic ovary syndrome improves after metformin therapy.
Kidney Blood Press Res. 2009; 32(1):24-31.KB

Abstract

BACKGROUND

Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation, hyperandrogenemia and insulin resistance. Hyperreninemia is observed in insulin resistance and hyperandrogenemic states.

AIMS

To investigate the levels of total plasma renin and their possible relationship with insulin resistance and hyperandrogenemia and to explore the effect of metformin on these parameters in PCOS women.

METHODS

48 PCOS women who were age- and body mass index (BMI)-matched with 21 healthy women were studied. Total renin, aldosterone levels, glucose and insulin levels were measured at basal state and during an oral glucose tolerance test in all subjects. A subgroup of women with PCOS was evaluated 6 months after metformin administration.

RESULTS

Total renin levels were significantly higher in PCOS women compared to controls. PCOS women compared to controls displayed higher areas under the curve for glucose, insulin and total renin (AUCREN). Mean AUCREN was correlated significantly with insulin resistance indices and positively with free testosterone levels. Total renin, aldosterone, androgen levels and insulin sensitivity indices were significantly improved after 6 months on metformin treatment.

CONCLUSIONS

PCOS women demonstrated an insulin resistance and hyperandogenemia-related increase in serum total renin levels. Metformin treatment was shown to significantly reduce total renin levels.

Authors+Show Affiliations

First Department of Internal Medicine, Laiko General Hospital, Athens, Greece. akandara@otenet.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19212122

Citation

Diamanti-Kandarakis, Evanthia, et al. "Hyperreninemia Characterizing Women With Polycystic Ovary Syndrome Improves After Metformin Therapy." Kidney & Blood Pressure Research, vol. 32, no. 1, 2009, pp. 24-31.
Diamanti-Kandarakis E, Economou FN, Livadas S, et al. Hyperreninemia characterizing women with polycystic ovary syndrome improves after metformin therapy. Kidney Blood Press Res. 2009;32(1):24-31.
Diamanti-Kandarakis, E., Economou, F. N., Livadas, S., Tantalaki, E., Piperi, C., Papavassiliou, A. G., & Panidis, D. (2009). Hyperreninemia characterizing women with polycystic ovary syndrome improves after metformin therapy. Kidney & Blood Pressure Research, 32(1), 24-31. https://doi.org/10.1159/000201791
Diamanti-Kandarakis E, et al. Hyperreninemia Characterizing Women With Polycystic Ovary Syndrome Improves After Metformin Therapy. Kidney Blood Press Res. 2009;32(1):24-31. PubMed PMID: 19212122.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperreninemia characterizing women with polycystic ovary syndrome improves after metformin therapy. AU - Diamanti-Kandarakis,Evanthia, AU - Economou,Frangiskos N, AU - Livadas,Sarantis, AU - Tantalaki,Evangelia, AU - Piperi,Christina, AU - Papavassiliou,Athanasios G, AU - Panidis,Dimitrios, Y1 - 2009/02/12/ PY - 2008/09/05/received PY - 2008/12/10/accepted PY - 2009/2/13/entrez PY - 2009/2/13/pubmed PY - 2009/5/19/medline SP - 24 EP - 31 JF - Kidney & blood pressure research JO - Kidney Blood Press Res VL - 32 IS - 1 N2 - BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation, hyperandrogenemia and insulin resistance. Hyperreninemia is observed in insulin resistance and hyperandrogenemic states. AIMS: To investigate the levels of total plasma renin and their possible relationship with insulin resistance and hyperandrogenemia and to explore the effect of metformin on these parameters in PCOS women. METHODS: 48 PCOS women who were age- and body mass index (BMI)-matched with 21 healthy women were studied. Total renin, aldosterone levels, glucose and insulin levels were measured at basal state and during an oral glucose tolerance test in all subjects. A subgroup of women with PCOS was evaluated 6 months after metformin administration. RESULTS: Total renin levels were significantly higher in PCOS women compared to controls. PCOS women compared to controls displayed higher areas under the curve for glucose, insulin and total renin (AUCREN). Mean AUCREN was correlated significantly with insulin resistance indices and positively with free testosterone levels. Total renin, aldosterone, androgen levels and insulin sensitivity indices were significantly improved after 6 months on metformin treatment. CONCLUSIONS: PCOS women demonstrated an insulin resistance and hyperandogenemia-related increase in serum total renin levels. Metformin treatment was shown to significantly reduce total renin levels. SN - 1423-0143 UR - https://www.unboundmedicine.com/medline/citation/19212122/Hyperreninemia_characterizing_women_with_polycystic_ovary_syndrome_improves_after_metformin_therapy_ L2 - https://www.karger.com?DOI=10.1159/000201791 DB - PRIME DP - Unbound Medicine ER -