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Effect of mouthrinse containing propolis on oral microorganisms and human gingival fibroblasts.

Abstract

OBJECTIVES

The aim of this study was to compare the effects of four different mouthrinse containing propolis solutions and mouthrinse containing 0.2% chlorhexidine (CHX) on oral microorganisms and human gingival fibroblasts.

METHODS

Four different solutions of propolis were prepared and propylene glycol and alcohol were used as solvents for each propolis sample. Mouthrinse containing propolis was prepared at four different concentrations as 10%, 5%, 2.5% and 1%. Besides, CHX was used as control group. The antibacterial effects of five solutions on oral microorganisms were tested and their cytotoxic effects on human gingival fibroblasts were evaluated by agar diffusion test.

RESULTS

At this concentrations effectiveness of mouthrinse containing propolis samples on oral microorganisms were not found as effective as CHX. On the contrary, samples found less cytotoxic on human gingival fibroblasts than CHX.

CONCLUSIONS

Standardized preparations of propolis can be used as a mouthrinse at appropriate concentrations. To obtain a standardized chemical composition, advanced researches are needed.

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  • Authors+Show Affiliations

    ,

    Department of Oral and Maxillofacial Surgery, School of Dentistry, Cumhuriyet University, Sivas, Turkey.

    , , , ,

    Source

    European journal of dentistry 1:4 2007 Oct pg 195-201

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19212467

    Citation

    Ozan, Fatih, et al. "Effect of Mouthrinse Containing Propolis On Oral Microorganisms and Human Gingival Fibroblasts." European Journal of Dentistry, vol. 1, no. 4, 2007, pp. 195-201.
    Ozan F, Sümer Z, Polat ZA, et al. Effect of mouthrinse containing propolis on oral microorganisms and human gingival fibroblasts. Eur J Dent. 2007;1(4):195-201.
    Ozan, F., Sümer, Z., Polat, Z. A., Er, K., Ozan, U., & Deger, O. (2007). Effect of mouthrinse containing propolis on oral microorganisms and human gingival fibroblasts. European Journal of Dentistry, 1(4), pp. 195-201.
    Ozan F, et al. Effect of Mouthrinse Containing Propolis On Oral Microorganisms and Human Gingival Fibroblasts. Eur J Dent. 2007;1(4):195-201. PubMed PMID: 19212467.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of mouthrinse containing propolis on oral microorganisms and human gingival fibroblasts. AU - Ozan,Fatih, AU - Sümer,Zeynep, AU - Polat,Zübeyde Akın, AU - Er,Kürşat, AU - Ozan,Ulkü, AU - Deger,Orhan, PY - 2009/2/13/entrez PY - 2007/10/1/pubmed PY - 2007/10/1/medline KW - Antibacterial activity KW - Cell culture KW - Chlorhexidine KW - Mouthrinse KW - Propolis SP - 195 EP - 201 JF - European journal of dentistry JO - Eur J Dent VL - 1 IS - 4 N2 - OBJECTIVES: The aim of this study was to compare the effects of four different mouthrinse containing propolis solutions and mouthrinse containing 0.2% chlorhexidine (CHX) on oral microorganisms and human gingival fibroblasts. METHODS: Four different solutions of propolis were prepared and propylene glycol and alcohol were used as solvents for each propolis sample. Mouthrinse containing propolis was prepared at four different concentrations as 10%, 5%, 2.5% and 1%. Besides, CHX was used as control group. The antibacterial effects of five solutions on oral microorganisms were tested and their cytotoxic effects on human gingival fibroblasts were evaluated by agar diffusion test. RESULTS: At this concentrations effectiveness of mouthrinse containing propolis samples on oral microorganisms were not found as effective as CHX. On the contrary, samples found less cytotoxic on human gingival fibroblasts than CHX. CONCLUSIONS: Standardized preparations of propolis can be used as a mouthrinse at appropriate concentrations. To obtain a standardized chemical composition, advanced researches are needed. SN - 1305-7456 UR - https://www.unboundmedicine.com/medline/citation/19212467/Effect_of_mouthrinse_containing_propolis_on_oral_microorganisms_and_human_gingival_fibroblasts_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19212467/ DB - PRIME DP - Unbound Medicine ER -