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Impact of obesity on metabolic syndrome components and adipokines in prepubertal children.
J Pediatr (Rio J). 2009 May-Jun; 85(3):261-8.JP

Abstract

OBJECTIVES

To verify the impact of obesity on metabolic syndrome components and adipokine levels in prepubertal children.

METHODS

This cross-sectional study compared 30 obese, 31 overweight and 33 eutrophic children attending a university hospital-based outpatient pediatric clinic. Parameters assessed included glucose, serum lipids, insulin, homeostasis model assessment-insulin resistance (HOMA-IR), glucose/insulin relation, adiponectin, and leptin. We compared the frequency of acanthosis nigricans and changes in waist, blood pressure, glucose, serum lipids, and insulin. The correlation between body mass index (BMI) z score and adipokines was evaluated.

RESULTS

Among obese children, there was a difference in the mean values of HDL cholesterol and adiponectin, whereas among the eutrophic children, there was a difference in the mean values of insulin, HOMA-IR, glucose/insulin relation, and leptin (p < 0.001). A difference was also observed regarding the frequency of acanthosis nigricans and alteration in waist and HDL cholesterol (p < 0.005) in the obese group. The BMI z score showed a positive correlation with leptin (p < 0.001) and a negative correlation with adiponectin (p = 0.001). In multiple linear regression, this correlation was maintained only for leptin; HDL-cholesterol correlated with adiponectin (p = 0.007) and HOMA-IR correlated with both variables (p < 0.05).

CONCLUSIONS

These findings provide evidence of the influence of obesity on metabolic syndrome components and on adipokine levels in prepubertal children, indicating that these components may contribute to the beginning of cardiovascular diseases.

Authors+Show Affiliations

Outpatient Clinic for Childhood Obesity Research. isamadeira@oi.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng por

PubMed ID

19212612

Citation

Madeira, Isabel R., et al. "Impact of Obesity On Metabolic Syndrome Components and Adipokines in Prepubertal Children." Jornal De Pediatria, vol. 85, no. 3, 2009, pp. 261-8.
Madeira IR, Carvalho CN, Gazolla FM, et al. Impact of obesity on metabolic syndrome components and adipokines in prepubertal children. J Pediatr (Rio J). 2009;85(3):261-8.
Madeira, I. R., Carvalho, C. N., Gazolla, F. M., Pinto, L. W., Borges, M. A., & Bordallo, M. A. (2009). Impact of obesity on metabolic syndrome components and adipokines in prepubertal children. Jornal De Pediatria, 85(3), 261-8. https://doi.org/10.2223/JPED.1873
Madeira IR, et al. Impact of Obesity On Metabolic Syndrome Components and Adipokines in Prepubertal Children. J Pediatr (Rio J). 2009;85(3):261-8. PubMed PMID: 19212612.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of obesity on metabolic syndrome components and adipokines in prepubertal children. AU - Madeira,Isabel R, AU - Carvalho,Cecilia N M, AU - Gazolla,Fernanda M, AU - Pinto,Liana W, AU - Borges,Marcos A, AU - Bordallo,Maria Alice N, Y1 - 2009/02/10/ PY - 2008/09/23/received PY - 2009/04/01/accepted PY - 2009/2/13/entrez PY - 2009/2/13/pubmed PY - 2009/12/16/medline SP - 261 EP - 8 JF - Jornal de pediatria JO - J Pediatr (Rio J) VL - 85 IS - 3 N2 - OBJECTIVES: To verify the impact of obesity on metabolic syndrome components and adipokine levels in prepubertal children. METHODS: This cross-sectional study compared 30 obese, 31 overweight and 33 eutrophic children attending a university hospital-based outpatient pediatric clinic. Parameters assessed included glucose, serum lipids, insulin, homeostasis model assessment-insulin resistance (HOMA-IR), glucose/insulin relation, adiponectin, and leptin. We compared the frequency of acanthosis nigricans and changes in waist, blood pressure, glucose, serum lipids, and insulin. The correlation between body mass index (BMI) z score and adipokines was evaluated. RESULTS: Among obese children, there was a difference in the mean values of HDL cholesterol and adiponectin, whereas among the eutrophic children, there was a difference in the mean values of insulin, HOMA-IR, glucose/insulin relation, and leptin (p < 0.001). A difference was also observed regarding the frequency of acanthosis nigricans and alteration in waist and HDL cholesterol (p < 0.005) in the obese group. The BMI z score showed a positive correlation with leptin (p < 0.001) and a negative correlation with adiponectin (p = 0.001). In multiple linear regression, this correlation was maintained only for leptin; HDL-cholesterol correlated with adiponectin (p = 0.007) and HOMA-IR correlated with both variables (p < 0.05). CONCLUSIONS: These findings provide evidence of the influence of obesity on metabolic syndrome components and on adipokine levels in prepubertal children, indicating that these components may contribute to the beginning of cardiovascular diseases. SN - 1678-4782 UR - https://www.unboundmedicine.com/medline/citation/19212612/Impact_of_obesity_on_metabolic_syndrome_components_and_adipokines_in_prepubertal_children_ DB - PRIME DP - Unbound Medicine ER -