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Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy.

Abstract

INTRODUCTION

Despite many therapeutic options, painful diabetic neuropathy is still a common and challenging complication of diabetes mellitus and is often resistant to treatment with current modalities.

METHODS

In this randomized, single-blind clinical trial we compared the efficacy of parenteral vitamin B(12) and nortriptyline, for symptomatic improvement of pain, paresthesia, burning, freezing, stabbing and electrical sensation. Changes in nerve conduction parameters of amplitude, duration and latency were also compared.

RESULTS

One hundred patients (50 in each group) completed the study. After treatment, the pain score based on a visual analogue scale decreased 3.66 units in the vitamin B(12) group and 0.84 units in the nortriptyline group (P <0.001). Similarly, the paresthesia score decreased 2.98 units versus 1.06 units (P <0.001). The decrements of tingling sensation were 3.48 units versus 1.02 units (P <0.001). Changes in vibration, position, pinprick and nerve conduction parameters were not significant in two groups.

CONCLUSION

In conclusion, vitamin B(12) is more effective than nortriptyline for the treatment of symptomatic painful diabetic neuropathy.

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  • Authors+Show Affiliations

    ,

    Department of Endocrinology, Arak University of Medical Sciences, Arak, Iran.

    , ,

    Source

    MeSH

    Adolescent
    Adult
    Analgesics, Non-Narcotic
    Anticonvulsants
    Antidepressive Agents, Tricyclic
    Blood Glucose
    Diabetic Neuropathies
    Female
    Glycated Hemoglobin A
    Humans
    Injections, Intramuscular
    Lipids
    Male
    Middle Aged
    Neural Conduction
    Neuralgia
    Neurons
    Nortriptyline
    Pain Measurement
    Paresthesia
    Surveys and Questionnaires
    Time Factors
    Vitamin B 12
    Young Adult

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    19212856

    Citation

    Talaei, Afsaneh, et al. "Vitamin B12 May Be More Effective Than Nortriptyline in Improving Painful Diabetic Neuropathy." International Journal of Food Sciences and Nutrition, vol. 60 Suppl 5, 2009, pp. 71-6.
    Talaei A, Siavash M, Majidi H, et al. Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy. Int J Food Sci Nutr. 2009;60 Suppl 5:71-6.
    Talaei, A., Siavash, M., Majidi, H., & Chehrei, A. (2009). Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy. International Journal of Food Sciences and Nutrition, 60 Suppl 5, pp. 71-6. doi:10.1080/09637480802406153.
    Talaei A, et al. Vitamin B12 May Be More Effective Than Nortriptyline in Improving Painful Diabetic Neuropathy. Int J Food Sci Nutr. 2009;60 Suppl 5:71-6. PubMed PMID: 19212856.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy. AU - Talaei,Afsaneh, AU - Siavash,Mansour, AU - Majidi,Hamid, AU - Chehrei,Ali, Y1 - 2009/02/11/ PY - 2009/2/13/entrez PY - 2009/2/13/pubmed PY - 2010/7/2/medline SP - 71 EP - 6 JF - International journal of food sciences and nutrition JO - Int J Food Sci Nutr VL - 60 Suppl 5 N2 - INTRODUCTION: Despite many therapeutic options, painful diabetic neuropathy is still a common and challenging complication of diabetes mellitus and is often resistant to treatment with current modalities. METHODS: In this randomized, single-blind clinical trial we compared the efficacy of parenteral vitamin B(12) and nortriptyline, for symptomatic improvement of pain, paresthesia, burning, freezing, stabbing and electrical sensation. Changes in nerve conduction parameters of amplitude, duration and latency were also compared. RESULTS: One hundred patients (50 in each group) completed the study. After treatment, the pain score based on a visual analogue scale decreased 3.66 units in the vitamin B(12) group and 0.84 units in the nortriptyline group (P <0.001). Similarly, the paresthesia score decreased 2.98 units versus 1.06 units (P <0.001). The decrements of tingling sensation were 3.48 units versus 1.02 units (P <0.001). Changes in vibration, position, pinprick and nerve conduction parameters were not significant in two groups. CONCLUSION: In conclusion, vitamin B(12) is more effective than nortriptyline for the treatment of symptomatic painful diabetic neuropathy. SN - 1465-3478 UR - https://www.unboundmedicine.com/medline/citation/19212856/full_citation L2 - http://www.tandfonline.com/doi/full/10.1080/09637480802406153 DB - PRIME DP - Unbound Medicine ER -