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Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy.
Int J Food Sci Nutr 2009; 60 Suppl 5:71-6IJ

Abstract

INTRODUCTION

Despite many therapeutic options, painful diabetic neuropathy is still a common and challenging complication of diabetes mellitus and is often resistant to treatment with current modalities.

METHODS

In this randomized, single-blind clinical trial we compared the efficacy of parenteral vitamin B(12) and nortriptyline, for symptomatic improvement of pain, paresthesia, burning, freezing, stabbing and electrical sensation. Changes in nerve conduction parameters of amplitude, duration and latency were also compared.

RESULTS

One hundred patients (50 in each group) completed the study. After treatment, the pain score based on a visual analogue scale decreased 3.66 units in the vitamin B(12) group and 0.84 units in the nortriptyline group (P <0.001). Similarly, the paresthesia score decreased 2.98 units versus 1.06 units (P <0.001). The decrements of tingling sensation were 3.48 units versus 1.02 units (P <0.001). Changes in vibration, position, pinprick and nerve conduction parameters were not significant in two groups.

CONCLUSION

In conclusion, vitamin B(12) is more effective than nortriptyline for the treatment of symptomatic painful diabetic neuropathy.

Authors+Show Affiliations

Department of Endocrinology, Arak University of Medical Sciences, Arak, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19212856

Citation

Talaei, Afsaneh, et al. "Vitamin B12 May Be More Effective Than Nortriptyline in Improving Painful Diabetic Neuropathy." International Journal of Food Sciences and Nutrition, vol. 60 Suppl 5, 2009, pp. 71-6.
Talaei A, Siavash M, Majidi H, et al. Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy. Int J Food Sci Nutr. 2009;60 Suppl 5:71-6.
Talaei, A., Siavash, M., Majidi, H., & Chehrei, A. (2009). Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy. International Journal of Food Sciences and Nutrition, 60 Suppl 5, pp. 71-6. doi:10.1080/09637480802406153.
Talaei A, et al. Vitamin B12 May Be More Effective Than Nortriptyline in Improving Painful Diabetic Neuropathy. Int J Food Sci Nutr. 2009;60 Suppl 5:71-6. PubMed PMID: 19212856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy. AU - Talaei,Afsaneh, AU - Siavash,Mansour, AU - Majidi,Hamid, AU - Chehrei,Ali, Y1 - 2009/02/11/ PY - 2009/2/13/entrez PY - 2009/2/13/pubmed PY - 2010/7/2/medline SP - 71 EP - 6 JF - International journal of food sciences and nutrition JO - Int J Food Sci Nutr VL - 60 Suppl 5 N2 - INTRODUCTION: Despite many therapeutic options, painful diabetic neuropathy is still a common and challenging complication of diabetes mellitus and is often resistant to treatment with current modalities. METHODS: In this randomized, single-blind clinical trial we compared the efficacy of parenteral vitamin B(12) and nortriptyline, for symptomatic improvement of pain, paresthesia, burning, freezing, stabbing and electrical sensation. Changes in nerve conduction parameters of amplitude, duration and latency were also compared. RESULTS: One hundred patients (50 in each group) completed the study. After treatment, the pain score based on a visual analogue scale decreased 3.66 units in the vitamin B(12) group and 0.84 units in the nortriptyline group (P <0.001). Similarly, the paresthesia score decreased 2.98 units versus 1.06 units (P <0.001). The decrements of tingling sensation were 3.48 units versus 1.02 units (P <0.001). Changes in vibration, position, pinprick and nerve conduction parameters were not significant in two groups. CONCLUSION: In conclusion, vitamin B(12) is more effective than nortriptyline for the treatment of symptomatic painful diabetic neuropathy. SN - 1465-3478 UR - https://www.unboundmedicine.com/medline/citation/19212856/full_citation L2 - http://www.tandfonline.com/doi/full/10.1080/09637480802406153 DB - PRIME DP - Unbound Medicine ER -