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Etiology and outcome of bronchiectasis in children: a study of 41 patients.
Tunis Med 2008; 86(11):996-9TM

Abstract

BACKGROUND

Bronchiectasis remains an important cause of chronic suppurative lung disease in the developing world. The aim of this study is to describe the epidemiological characteristics, clinical features, underlying aetiologies and outcome of bronchiectasis in the paediatric hospital of Tunis.

METHODS

A retrospective study of 41 children with bronchiectasis was conducted between January 1994 and December 2006. Diagnosis was made in patients with clinical suspicion of bronchiectasis associated with abnormalities on chest X ray (n=37) and/or on high resolution computed tomography (HRCT) (n=36).

RESULTS

Mean age at diagnosis was 5 years 9 months; (range: 6 months-14 years). Persistent cough and bronchorrhea were the most common symptoms. Fourteen patients (34%) had dyspnoea on first presentation, 11 of them (26.8%) had chest deformation and/or finger clubbing. Haemoptysis was noted in only two cases. Mean time to diagnosis from symptom onset was 2.7 years (range: 2 months-4 years). The underlying aetiologies were identified in 52% of patients. Cystic fibrosis (17%), previous pneumonic illness (9.7%), primary ciliary dyskinesia (9.7%) and immunodeficiency (9.7%) were the most common causes. After a mean follow-up of 6.6 years, the annual lower respiratory infection rate decreased from 7.2 +/- 3 to 3.1 +/- 2.6 (p<0.05), Twenty one point nine per cent of patients had chronic respiratory failure and five patients required surgery.

CONCLUSIONS

Delays diagnosis of bronchiectasis remains important in our country. Congenital and indeterminate aetiologies are the most common forms. Prognosis is poor with a high prevalence of chronic respiratory failure.

Authors+Show Affiliations

Paediatric Department C, Paediatric Hospital of Tunis, Tunisia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19213492

Citation

Bouyahia, Olfa, et al. "Etiology and Outcome of Bronchiectasis in Children: a Study of 41 Patients." La Tunisie Medicale, vol. 86, no. 11, 2008, pp. 996-9.
Bouyahia O, Essadem L, Matoussi N, et al. Etiology and outcome of bronchiectasis in children: a study of 41 patients. Tunis Med. 2008;86(11):996-9.
Bouyahia, O., Essadem, L., Matoussi, N., Gharsallah, L., Fitouri, Z., Mrad Mazigh, S., ... Sammoud El Gharbi, A. (2008). Etiology and outcome of bronchiectasis in children: a study of 41 patients. La Tunisie Medicale, 86(11), pp. 996-9.
Bouyahia O, et al. Etiology and Outcome of Bronchiectasis in Children: a Study of 41 Patients. Tunis Med. 2008;86(11):996-9. PubMed PMID: 19213492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Etiology and outcome of bronchiectasis in children: a study of 41 patients. AU - Bouyahia,Olfa, AU - Essadem,Leila, AU - Matoussi,Nadia, AU - Gharsallah,Lamia, AU - Fitouri,Zohra, AU - Mrad Mazigh,Sonia, AU - Boukthir,Samir, AU - Bellagah,I, AU - Ben Becher,Saida, AU - Sammoud El Gharbi,Azza, PY - 2009/2/14/entrez PY - 2009/2/14/pubmed PY - 2009/3/14/medline SP - 996 EP - 9 JF - La Tunisie medicale JO - Tunis Med VL - 86 IS - 11 N2 - BACKGROUND: Bronchiectasis remains an important cause of chronic suppurative lung disease in the developing world. The aim of this study is to describe the epidemiological characteristics, clinical features, underlying aetiologies and outcome of bronchiectasis in the paediatric hospital of Tunis. METHODS: A retrospective study of 41 children with bronchiectasis was conducted between January 1994 and December 2006. Diagnosis was made in patients with clinical suspicion of bronchiectasis associated with abnormalities on chest X ray (n=37) and/or on high resolution computed tomography (HRCT) (n=36). RESULTS: Mean age at diagnosis was 5 years 9 months; (range: 6 months-14 years). Persistent cough and bronchorrhea were the most common symptoms. Fourteen patients (34%) had dyspnoea on first presentation, 11 of them (26.8%) had chest deformation and/or finger clubbing. Haemoptysis was noted in only two cases. Mean time to diagnosis from symptom onset was 2.7 years (range: 2 months-4 years). The underlying aetiologies were identified in 52% of patients. Cystic fibrosis (17%), previous pneumonic illness (9.7%), primary ciliary dyskinesia (9.7%) and immunodeficiency (9.7%) were the most common causes. After a mean follow-up of 6.6 years, the annual lower respiratory infection rate decreased from 7.2 +/- 3 to 3.1 +/- 2.6 (p<0.05), Twenty one point nine per cent of patients had chronic respiratory failure and five patients required surgery. CONCLUSIONS: Delays diagnosis of bronchiectasis remains important in our country. Congenital and indeterminate aetiologies are the most common forms. Prognosis is poor with a high prevalence of chronic respiratory failure. SN - 0041-4131 UR - https://www.unboundmedicine.com/medline/citation/19213492/Etiology_and_outcome_of_bronchiectasis_in_children:_a_study_of_41_patients_ L2 - http://www.diseaseinfosearch.org/result/7870 DB - PRIME DP - Unbound Medicine ER -