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Dietary patterns in pregnancy and respiratory and atopic outcomes in childhood.
Thorax. 2009 May; 64(5):411-7.T

Abstract

BACKGROUND

Studies of the relation between maternal diet in pregnancy and respiratory and atopic outcomes in the offspring have focused on the effects of individual nutrients and foods rather than dietary patterns. A study was undertaken to determine whether dietary patterns in pregnancy are related to childhood asthma and related outcomes.

METHODS

In a population-based birth cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC), dietary patterns in pregnancy previously identified using principal components analysis ("health conscious", "traditional", "processed", "vegetarian" and "confectionery") were related to early wheezing phenotypes and eczema; wheezing, hay fever, eczema, doctor-diagnosed asthma, atopy and total IgE at 7 years; lung function and bronchial responsiveness at 8-9 years. In regression models, confounders were controlled for using propensity scores.

RESULTS

Univariately, the "health conscious" pattern was positively associated with eczema, total IgE, forced expiratory volume in 1 s and forced expiratory flow and negatively associated with early wheezing and asthma (unadjusted odds ratios per standard deviation increase in pattern score for early persistent wheeze and asthma: 0.78 (95% CI 0.70 to 0.87), p = 7.3x10(-6), N = 8886 and 0.90 (95% CI 0.84 to 0.97), p = 0.007, N = 7625, respectively). The "processed" pattern was positively associated with early wheezing and negatively associated with atopy and forced vital capacity. On controlling for confounders, the effects were substantially attenuated and became non-significant (adjusted odds ratios for the associations of the "health conscious" pattern with early persistent wheeze and asthma: 1.00 (0.86 to 1.16), p = 0.99 and 0.95 (0.86 to 1.04), p = 0.27, respectively).

CONCLUSIONS

In this cohort, dietary patterns in pregnancy did not predict asthma and related outcomes in the offspring after controlling for confounders.

Authors+Show Affiliations

National Heart and Lung Institute, Imperial College London, UK. s.shaheen@imperial.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19213776

Citation

Shaheen, S O., et al. "Dietary Patterns in Pregnancy and Respiratory and Atopic Outcomes in Childhood." Thorax, vol. 64, no. 5, 2009, pp. 411-7.
Shaheen SO, Northstone K, Newson RB, et al. Dietary patterns in pregnancy and respiratory and atopic outcomes in childhood. Thorax. 2009;64(5):411-7.
Shaheen, S. O., Northstone, K., Newson, R. B., Emmett, P. M., Sherriff, A., & Henderson, A. J. (2009). Dietary patterns in pregnancy and respiratory and atopic outcomes in childhood. Thorax, 64(5), 411-7. https://doi.org/10.1136/thx.2008.104703
Shaheen SO, et al. Dietary Patterns in Pregnancy and Respiratory and Atopic Outcomes in Childhood. Thorax. 2009;64(5):411-7. PubMed PMID: 19213776.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary patterns in pregnancy and respiratory and atopic outcomes in childhood. AU - Shaheen,S O, AU - Northstone,K, AU - Newson,R B, AU - Emmett,P M, AU - Sherriff,A, AU - Henderson,A J, Y1 - 2009/02/12/ PY - 2009/2/14/entrez PY - 2009/2/14/pubmed PY - 2009/6/19/medline SP - 411 EP - 7 JF - Thorax JO - Thorax VL - 64 IS - 5 N2 - BACKGROUND: Studies of the relation between maternal diet in pregnancy and respiratory and atopic outcomes in the offspring have focused on the effects of individual nutrients and foods rather than dietary patterns. A study was undertaken to determine whether dietary patterns in pregnancy are related to childhood asthma and related outcomes. METHODS: In a population-based birth cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC), dietary patterns in pregnancy previously identified using principal components analysis ("health conscious", "traditional", "processed", "vegetarian" and "confectionery") were related to early wheezing phenotypes and eczema; wheezing, hay fever, eczema, doctor-diagnosed asthma, atopy and total IgE at 7 years; lung function and bronchial responsiveness at 8-9 years. In regression models, confounders were controlled for using propensity scores. RESULTS: Univariately, the "health conscious" pattern was positively associated with eczema, total IgE, forced expiratory volume in 1 s and forced expiratory flow and negatively associated with early wheezing and asthma (unadjusted odds ratios per standard deviation increase in pattern score for early persistent wheeze and asthma: 0.78 (95% CI 0.70 to 0.87), p = 7.3x10(-6), N = 8886 and 0.90 (95% CI 0.84 to 0.97), p = 0.007, N = 7625, respectively). The "processed" pattern was positively associated with early wheezing and negatively associated with atopy and forced vital capacity. On controlling for confounders, the effects were substantially attenuated and became non-significant (adjusted odds ratios for the associations of the "health conscious" pattern with early persistent wheeze and asthma: 1.00 (0.86 to 1.16), p = 0.99 and 0.95 (0.86 to 1.04), p = 0.27, respectively). CONCLUSIONS: In this cohort, dietary patterns in pregnancy did not predict asthma and related outcomes in the offspring after controlling for confounders. SN - 1468-3296 UR - https://www.unboundmedicine.com/medline/citation/19213776/Dietary_patterns_in_pregnancy_and_respiratory_and_atopic_outcomes_in_childhood_ L2 - https://thorax.bmj.com/lookup/pmidlookup?view=long&pmid=19213776 DB - PRIME DP - Unbound Medicine ER -