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Protective effects of selenium, zinc, or their combination on cadmium-induced oxidative stress in rat kidney.
Biol Trace Elem Res 2009; 130(2):152-61BT

Abstract

The present study was conducted to investigate whether the combined treatment with Se and Zn offers more beneficial effects than that provided by either of them alone in reversing Cd-induced oxidative stress in the kidney of rat. For this purpose, 30 adult male Wistar albino rats, equally divided into control and four treated groups, received either 200 ppm Cd (as CdCl(2)), 200 ppm Cd + 500 ppm Zn (as ZnCl(2)), 200 ppm Cd + 0.1 ppm Se (as Na(2)SeO(3)), or 200 ppm Cd + 500 ppm Zn + 0.1 ppm Se in their drinking water for 35 days. The results showed that Cd treatment decreased significantly the catalase (CAT) and glutathione peroxidase (GSH-Px) activities, whereas the superoxide dismutase (SOD) activity and the renal levels of lipid peroxidation (as malondialdehyde, MDA) were increased compared to control rats. The treatment of Cd-exposed rats with Se alone had no significant effect on the Cd-induced increase in the MDA concentrations but increased significantly the CAT activities and reversed Cd-induced increase in SOD activity. It also partially prevented Cd-induced decrease in GSH-Px activity. The treatment of Cd-exposed animals with Zn alone increased significantly the CAT activity and partially protected against Cd-induced increase in the MDA concentrations, whereas it had no significant effect on the Cd-induced increase in SOD activity and decrease in GSH-Px activity. The combined treatment of Cd-exposed animals with Se and Zn was more effective than that with either of them alone in reversing Cd-induced decrease in CAT and GSH-Px activities and Cd-induced increase in MDA concentrations. Results demonstrated beneficial effects of combined Se and Zn treatment in Cd-induced oxidative stress in kidney and suggest that Se and Zn can have a synergistic role against Cd toxicity.

Authors+Show Affiliations

UR 09/30: Génétique, Biodiversité et Valorisation des Bioressources, Institut de Biotechnologie, Monastir, Tunisia. imed_messaoudi@yahoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19214400

Citation

Messaoudi, Imed, et al. "Protective Effects of Selenium, Zinc, or Their Combination On Cadmium-induced Oxidative Stress in Rat Kidney." Biological Trace Element Research, vol. 130, no. 2, 2009, pp. 152-61.
Messaoudi I, El Heni J, Hammouda F, et al. Protective effects of selenium, zinc, or their combination on cadmium-induced oxidative stress in rat kidney. Biol Trace Elem Res. 2009;130(2):152-61.
Messaoudi, I., El Heni, J., Hammouda, F., Saïd, K., & Kerkeni, A. (2009). Protective effects of selenium, zinc, or their combination on cadmium-induced oxidative stress in rat kidney. Biological Trace Element Research, 130(2), pp. 152-61. doi:10.1007/s12011-009-8324-y.
Messaoudi I, et al. Protective Effects of Selenium, Zinc, or Their Combination On Cadmium-induced Oxidative Stress in Rat Kidney. Biol Trace Elem Res. 2009;130(2):152-61. PubMed PMID: 19214400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of selenium, zinc, or their combination on cadmium-induced oxidative stress in rat kidney. AU - Messaoudi,Imed, AU - El Heni,Jihen, AU - Hammouda,Fatima, AU - Saïd,Khaled, AU - Kerkeni,Abdelhamid, Y1 - 2009/02/13/ PY - 2008/10/27/received PY - 2009/01/13/accepted PY - 2009/2/14/entrez PY - 2009/2/14/pubmed PY - 2009/9/8/medline SP - 152 EP - 61 JF - Biological trace element research JO - Biol Trace Elem Res VL - 130 IS - 2 N2 - The present study was conducted to investigate whether the combined treatment with Se and Zn offers more beneficial effects than that provided by either of them alone in reversing Cd-induced oxidative stress in the kidney of rat. For this purpose, 30 adult male Wistar albino rats, equally divided into control and four treated groups, received either 200 ppm Cd (as CdCl(2)), 200 ppm Cd + 500 ppm Zn (as ZnCl(2)), 200 ppm Cd + 0.1 ppm Se (as Na(2)SeO(3)), or 200 ppm Cd + 500 ppm Zn + 0.1 ppm Se in their drinking water for 35 days. The results showed that Cd treatment decreased significantly the catalase (CAT) and glutathione peroxidase (GSH-Px) activities, whereas the superoxide dismutase (SOD) activity and the renal levels of lipid peroxidation (as malondialdehyde, MDA) were increased compared to control rats. The treatment of Cd-exposed rats with Se alone had no significant effect on the Cd-induced increase in the MDA concentrations but increased significantly the CAT activities and reversed Cd-induced increase in SOD activity. It also partially prevented Cd-induced decrease in GSH-Px activity. The treatment of Cd-exposed animals with Zn alone increased significantly the CAT activity and partially protected against Cd-induced increase in the MDA concentrations, whereas it had no significant effect on the Cd-induced increase in SOD activity and decrease in GSH-Px activity. The combined treatment of Cd-exposed animals with Se and Zn was more effective than that with either of them alone in reversing Cd-induced decrease in CAT and GSH-Px activities and Cd-induced increase in MDA concentrations. Results demonstrated beneficial effects of combined Se and Zn treatment in Cd-induced oxidative stress in kidney and suggest that Se and Zn can have a synergistic role against Cd toxicity. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/19214400/Protective_effects_of_selenium_zinc_or_their_combination_on_cadmium_induced_oxidative_stress_in_rat_kidney_ L2 - https://dx.doi.org/10.1007/s12011-009-8324-y DB - PRIME DP - Unbound Medicine ER -