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The Phycodnaviridae: the story of how tiny giants rule the world.
Curr Top Microbiol Immunol. 2009; 328:1-42.CT

Abstract

The family Phycodnaviridae encompasses a diverse and rapidly expanding collection of large icosahedral, dsDNA viruses that infect algae. These lytic and lysogenic viruses have genomes ranging from 160 to 560 kb. The family consists of six genera based initially on host range and supported by sequence comparisons. The family is monophyletic with branches for each genus, but the phycodnaviruses have evolutionary roots that connect them with several other families of large DNA viruses, referred to as the nucleocytoplasmic large DNA viruses (NCLDV). The phycodnaviruses have diverse genome structures, some with large regions of noncoding sequence and others with regions of ssDNA. The genomes of members in three genera in the Phycodnaviridae have been sequenced. The genome analyses have revealed more than 1000 unique genes, with only 14 homologous genes in common among the three genera of phycodnaviruses sequenced to date. Thus, their gene diversity far exceeds the number of so-called core genes. Not much is known about the replication of these viruses, but the consequences of these infections on phytoplankton have global affects, including influencing geochemical cycling and weather patterns.

Authors+Show Affiliations

Bigelow Laboratory for Ocean Sciences, 180 McKown Point, P.O. Box 475, West Boothbay Harbor, ME 04575-0475, USA. wwilson@bigelow.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

19216434

Citation

Wilson, W H., et al. "The Phycodnaviridae: the Story of How Tiny Giants Rule the World." Current Topics in Microbiology and Immunology, vol. 328, 2009, pp. 1-42.
Wilson WH, Van Etten JL, Allen MJ. The Phycodnaviridae: the story of how tiny giants rule the world. Curr Top Microbiol Immunol. 2009;328:1-42.
Wilson, W. H., Van Etten, J. L., & Allen, M. J. (2009). The Phycodnaviridae: the story of how tiny giants rule the world. Current Topics in Microbiology and Immunology, 328, 1-42.
Wilson WH, Van Etten JL, Allen MJ. The Phycodnaviridae: the Story of How Tiny Giants Rule the World. Curr Top Microbiol Immunol. 2009;328:1-42. PubMed PMID: 19216434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Phycodnaviridae: the story of how tiny giants rule the world. AU - Wilson,W H, AU - Van Etten,J L, AU - Allen,M J, PY - 2009/2/17/entrez PY - 2009/2/17/pubmed PY - 2009/3/13/medline SP - 1 EP - 42 JF - Current topics in microbiology and immunology JO - Curr Top Microbiol Immunol VL - 328 N2 - The family Phycodnaviridae encompasses a diverse and rapidly expanding collection of large icosahedral, dsDNA viruses that infect algae. These lytic and lysogenic viruses have genomes ranging from 160 to 560 kb. The family consists of six genera based initially on host range and supported by sequence comparisons. The family is monophyletic with branches for each genus, but the phycodnaviruses have evolutionary roots that connect them with several other families of large DNA viruses, referred to as the nucleocytoplasmic large DNA viruses (NCLDV). The phycodnaviruses have diverse genome structures, some with large regions of noncoding sequence and others with regions of ssDNA. The genomes of members in three genera in the Phycodnaviridae have been sequenced. The genome analyses have revealed more than 1000 unique genes, with only 14 homologous genes in common among the three genera of phycodnaviruses sequenced to date. Thus, their gene diversity far exceeds the number of so-called core genes. Not much is known about the replication of these viruses, but the consequences of these infections on phytoplankton have global affects, including influencing geochemical cycling and weather patterns. SN - 0070-217X UR - https://www.unboundmedicine.com/medline/citation/19216434/The_Phycodnaviridae:_the_story_of_how_tiny_giants_rule_the_world_ L2 - https://doi.org/10.1007/978-3-540-68618-7_1 DB - PRIME DP - Unbound Medicine ER -
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