Tags

Type your tag names separated by a space and hit enter

Vasoactive intestinal polypeptide and gastrin-producing islet cell carcinoma.
Arch Pathol Lab Med. 1977 May; 101(5):262-5.AP

Abstract

A 61-year-old woman had watery diarrhea, hypochlorhydria, hypokalemia, and elevated serum gastrin levels. She had islet cell carcinoma of the body of the pancreas with multiple metastases to the liver. Radioimmunoassay and immunofluorescence demonstrated both vasoactive intestinal polypeptide (VIP) and gastrin in the surgically removed carcinoma and in a metastatic focus. Electron microscopical findings confirmed the presence of two cell types whose secretory granules had characteristics ascribed to these two hormones. Plasma prostaglandin E levels were also elevated above normal. Serum VIP levels became elevated to the Verner-Morrison range prior to her death of a bleeding duodenal ulcer two years after initial symptoms.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

192171

Citation

Judge, D M., et al. "Vasoactive Intestinal Polypeptide and Gastrin-producing Islet Cell Carcinoma." Archives of Pathology & Laboratory Medicine, vol. 101, no. 5, 1977, pp. 262-5.
Judge DM, Demers LM, Nahrwold DL, et al. Vasoactive intestinal polypeptide and gastrin-producing islet cell carcinoma. Arch Pathol Lab Med. 1977;101(5):262-5.
Judge, D. M., Demers, L. M., Nahrwold, D. L., Dickman, P. S., Petrokubi, R. J., & Trapukdi, S. (1977). Vasoactive intestinal polypeptide and gastrin-producing islet cell carcinoma. Archives of Pathology & Laboratory Medicine, 101(5), 262-5.
Judge DM, et al. Vasoactive Intestinal Polypeptide and Gastrin-producing Islet Cell Carcinoma. Arch Pathol Lab Med. 1977;101(5):262-5. PubMed PMID: 192171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vasoactive intestinal polypeptide and gastrin-producing islet cell carcinoma. AU - Judge,D M, AU - Demers,L M, AU - Nahrwold,D L, AU - Dickman,P S, AU - Petrokubi,R J, AU - Trapukdi,S, PY - 1977/5/1/pubmed PY - 1977/5/1/medline PY - 1977/5/1/entrez SP - 262 EP - 5 JF - Archives of pathology & laboratory medicine JO - Arch Pathol Lab Med VL - 101 IS - 5 N2 - A 61-year-old woman had watery diarrhea, hypochlorhydria, hypokalemia, and elevated serum gastrin levels. She had islet cell carcinoma of the body of the pancreas with multiple metastases to the liver. Radioimmunoassay and immunofluorescence demonstrated both vasoactive intestinal polypeptide (VIP) and gastrin in the surgically removed carcinoma and in a metastatic focus. Electron microscopical findings confirmed the presence of two cell types whose secretory granules had characteristics ascribed to these two hormones. Plasma prostaglandin E levels were also elevated above normal. Serum VIP levels became elevated to the Verner-Morrison range prior to her death of a bleeding duodenal ulcer two years after initial symptoms. SN - 0003-9985 UR - https://www.unboundmedicine.com/medline/citation/192171/Vasoactive_intestinal_polypeptide_and_gastrin_producing_islet_cell_carcinoma_ L2 - https://medlineplus.gov/pancreaticcancer.html DB - PRIME DP - Unbound Medicine ER -