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Immune modulation in the blue mussel Mytilus edulis exposed to North Sea produced water.
Environ Pollut. 2009 Jun; 157(6):1939-44.EP

Abstract

The discharge of oil well produced water (PW) provides a constant source of contaminants to the marine environment including polycyclic aromatic hydrocarbons, alkylated phenols, metals and production chemicals. High concentrations of PW cause adverse effects to exposed biota, including reduced survival, growth and reproduction. Here we explore the effects of PW on immune function in the blue mussel, Mytilus edulis. Mussels were exposed for 21 days to sublethal PW concentrations (0.125-0.5%) and cellular parameters were measured. Cell viability, phagocytosis and cytotoxicity were inhibited after exposure to 0.25% and 0.5% PW, whilst the 0.125% PW treatment produced significant increases in these biomarker responses. This biphasic response was only observed after 7 days exposure; longer exposure periods led to a reduction in immune parameters. Results indicate that PW concentrations close to the discharge point cause modulation to cellular immunity. The implications for longer-term disease resistance are discussed.

Authors+Show Affiliations

Ecotoxicology & Stress Biology Research Centre, School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth, Devon, PL4 8AA, UK. marie.hannam@plymouth.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19217195

Citation

Hannam, M L., et al. "Immune Modulation in the Blue Mussel Mytilus Edulis Exposed to North Sea Produced Water." Environmental Pollution (Barking, Essex : 1987), vol. 157, no. 6, 2009, pp. 1939-44.
Hannam ML, Bamber SD, Sundt RC, et al. Immune modulation in the blue mussel Mytilus edulis exposed to North Sea produced water. Environ Pollut. 2009;157(6):1939-44.
Hannam, M. L., Bamber, S. D., Sundt, R. C., & Galloway, T. S. (2009). Immune modulation in the blue mussel Mytilus edulis exposed to North Sea produced water. Environmental Pollution (Barking, Essex : 1987), 157(6), 1939-44. https://doi.org/10.1016/j.envpol.2008.12.031
Hannam ML, et al. Immune Modulation in the Blue Mussel Mytilus Edulis Exposed to North Sea Produced Water. Environ Pollut. 2009;157(6):1939-44. PubMed PMID: 19217195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immune modulation in the blue mussel Mytilus edulis exposed to North Sea produced water. AU - Hannam,M L, AU - Bamber,S D, AU - Sundt,R C, AU - Galloway,T S, Y1 - 2009/02/12/ PY - 2008/10/24/received PY - 2008/12/12/revised PY - 2008/12/18/accepted PY - 2009/2/17/entrez PY - 2009/2/17/pubmed PY - 2009/11/5/medline SP - 1939 EP - 44 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ Pollut VL - 157 IS - 6 N2 - The discharge of oil well produced water (PW) provides a constant source of contaminants to the marine environment including polycyclic aromatic hydrocarbons, alkylated phenols, metals and production chemicals. High concentrations of PW cause adverse effects to exposed biota, including reduced survival, growth and reproduction. Here we explore the effects of PW on immune function in the blue mussel, Mytilus edulis. Mussels were exposed for 21 days to sublethal PW concentrations (0.125-0.5%) and cellular parameters were measured. Cell viability, phagocytosis and cytotoxicity were inhibited after exposure to 0.25% and 0.5% PW, whilst the 0.125% PW treatment produced significant increases in these biomarker responses. This biphasic response was only observed after 7 days exposure; longer exposure periods led to a reduction in immune parameters. Results indicate that PW concentrations close to the discharge point cause modulation to cellular immunity. The implications for longer-term disease resistance are discussed. SN - 1873-6424 UR - https://www.unboundmedicine.com/medline/citation/19217195/Immune_modulation_in_the_blue_mussel_Mytilus_edulis_exposed_to_North_Sea_produced_water_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0269-7491(09)00027-X DB - PRIME DP - Unbound Medicine ER -