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Characterization and zoonotic potential of endemic hepatitis E virus (HEV) strains in humans and animals in Hungary.
J Clin Virol. 2009 Apr; 44(4):277-81.JC

Abstract

BACKGROUND

Hepatitis E virus (HEV) is a common cause of acute, fecally transmitted hepatitis in developing countries. Identification of HEV in indigenous human infection and in domestic pig raising the possibility that HEV infection is also a zoonosis.

OBJECTIVES/STUDY DESIGN

Molecular detection and epidemiology of HEV in humans (South-East Hungary) with acute hepatitis and in domestic (pig, cattle) and wild (boar and roe-deer) animals (countrywide) by ELISA and RT-PCR.

RESULTS

Between 2001 and 2006, a total of 116 (9.6%) of 1203 human sera were positive by HEV IgM ELISA and 13 (24.5%) of 53 samples were also confirmed by RT-PCR and sequencing. Forty-two (27.3%) of 154, 11 (34.4%) of 32 and 9 (12.2%) of 74 samples were RT-PCR-positive from swine (feces: 22.7%; liver: 30.8%), roe-deer (liver) and wild boar (liver), respectively. Except for an imported infection caused by genotype 1, 19 sequences (human: 12, swine: 4, roe-deer: 1, wild boar: 2) belong to genotype 3 HEV. Genetically identical strains were detected in human and roe-deer and in 2 other human clusters.

CONCLUSIONS

HEV is an endemic agent in Hungary. Consumption of raw or undercooked meat-products is one of the possible sources of the indigenous HEV infections. Cross-species infection with genotype 3 HEV potentially involves a food-borne transmission route in Hungary.

Authors+Show Affiliations

Regional Laboratory of Virology, ANTSZ Regional Institute of State Public Health Service, Pécs, Hungary. reuter.gabor@baranya.antsz.huNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19217346

Citation

Reuter, Gábor, et al. "Characterization and Zoonotic Potential of Endemic Hepatitis E Virus (HEV) Strains in Humans and Animals in Hungary." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 44, no. 4, 2009, pp. 277-81.
Reuter G, Fodor D, Forgách P, et al. Characterization and zoonotic potential of endemic hepatitis E virus (HEV) strains in humans and animals in Hungary. J Clin Virol. 2009;44(4):277-81.
Reuter, G., Fodor, D., Forgách, P., Kátai, A., & Szucs, G. (2009). Characterization and zoonotic potential of endemic hepatitis E virus (HEV) strains in humans and animals in Hungary. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 44(4), 277-81. https://doi.org/10.1016/j.jcv.2009.01.008
Reuter G, et al. Characterization and Zoonotic Potential of Endemic Hepatitis E Virus (HEV) Strains in Humans and Animals in Hungary. J Clin Virol. 2009;44(4):277-81. PubMed PMID: 19217346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization and zoonotic potential of endemic hepatitis E virus (HEV) strains in humans and animals in Hungary. AU - Reuter,Gábor, AU - Fodor,Domonka, AU - Forgách,Petra, AU - Kátai,Andrea, AU - Szucs,György, Y1 - 2009/02/12/ PY - 2008/03/27/received PY - 2008/12/30/revised PY - 2009/01/14/accepted PY - 2009/2/17/entrez PY - 2009/2/17/pubmed PY - 2009/4/25/medline SP - 277 EP - 81 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 44 IS - 4 N2 - BACKGROUND: Hepatitis E virus (HEV) is a common cause of acute, fecally transmitted hepatitis in developing countries. Identification of HEV in indigenous human infection and in domestic pig raising the possibility that HEV infection is also a zoonosis. OBJECTIVES/STUDY DESIGN: Molecular detection and epidemiology of HEV in humans (South-East Hungary) with acute hepatitis and in domestic (pig, cattle) and wild (boar and roe-deer) animals (countrywide) by ELISA and RT-PCR. RESULTS: Between 2001 and 2006, a total of 116 (9.6%) of 1203 human sera were positive by HEV IgM ELISA and 13 (24.5%) of 53 samples were also confirmed by RT-PCR and sequencing. Forty-two (27.3%) of 154, 11 (34.4%) of 32 and 9 (12.2%) of 74 samples were RT-PCR-positive from swine (feces: 22.7%; liver: 30.8%), roe-deer (liver) and wild boar (liver), respectively. Except for an imported infection caused by genotype 1, 19 sequences (human: 12, swine: 4, roe-deer: 1, wild boar: 2) belong to genotype 3 HEV. Genetically identical strains were detected in human and roe-deer and in 2 other human clusters. CONCLUSIONS: HEV is an endemic agent in Hungary. Consumption of raw or undercooked meat-products is one of the possible sources of the indigenous HEV infections. Cross-species infection with genotype 3 HEV potentially involves a food-borne transmission route in Hungary. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/19217346/Characterization_and_zoonotic_potential_of_endemic_hepatitis_E_virus__HEV__strains_in_humans_and_animals_in_Hungary_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(09)00036-5 DB - PRIME DP - Unbound Medicine ER -