Tags

Type your tag names separated by a space and hit enter

Accelerated hippocampal atrophy rates in stable and progressive amnestic mild cognitive impairment.
Psychiatry Res. 2009 Mar 31; 171(3):221-31.PR

Abstract

Studies suggest that smaller hippocampal volume predicts Alzheimer's disease (AD) in mild cognitive impairment (MCI). However, few studies have demonstrated decline rates in cognition and hippocampal volume in MCI subjects with stable clinical presentation. Furthermore, the effects of apolipoprotein E (ApoE) on the change rates of medial temporal structures and cognition in MCI are rarely investigated. Fifty-eight subjects with amnestic MCI and 20 normal aging elderly controls received annual neuropsychological and magnetic resonance imaging (MRI) assessments. Annual decline rates in neuropsychological test scores, hippocampal and amygdalar volumes were calculated. ApoE genotypes were examined. Nineteen (32.7%) MCI subjects converted to AD during an average 22.5-month follow-up period. The annual hippocampal atrophy rate was correlated with a decline in memory test scores. The presence of the ApoE varepsilon4 allele did not affect the change rates in neuropsychological test scores and medial temporal structures volume. Compared to subjects with stable MCI (MCI-S) and normal aging, progressive MCI (MCI-P) had the highest annual decline rates in cognition and hippocampal volume. Logistic regression analysis showed that higher annual decline rates in hippocampal volume and global cognitive test scores were associated with conversion to AD. Furthermore, although MCI-S subjects had little cognitive decline, their hippocampal atrophy rates were higher than those of normal aging controls. Therefore, accelerated hippocampal atrophy rates may be an early and important presentation in MCI subjects.

Authors+Show Affiliations

Department of Neurology, National Yang-Ming University School of Medicine, Taipei, Taiwan. pnwang@vghtpe.gov.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19217759

Citation

Wang, Pei-Ning, et al. "Accelerated Hippocampal Atrophy Rates in Stable and Progressive Amnestic Mild Cognitive Impairment." Psychiatry Research, vol. 171, no. 3, 2009, pp. 221-31.
Wang PN, Liu HC, Lirng JF, et al. Accelerated hippocampal atrophy rates in stable and progressive amnestic mild cognitive impairment. Psychiatry Res. 2009;171(3):221-31.
Wang, P. N., Liu, H. C., Lirng, J. F., Lin, K. N., & Wu, Z. A. (2009). Accelerated hippocampal atrophy rates in stable and progressive amnestic mild cognitive impairment. Psychiatry Research, 171(3), 221-31. https://doi.org/10.1016/j.pscychresns.2008.05.002
Wang PN, et al. Accelerated Hippocampal Atrophy Rates in Stable and Progressive Amnestic Mild Cognitive Impairment. Psychiatry Res. 2009 Mar 31;171(3):221-31. PubMed PMID: 19217759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Accelerated hippocampal atrophy rates in stable and progressive amnestic mild cognitive impairment. AU - Wang,Pei-Ning, AU - Liu,Hsiu-Chih, AU - Lirng,Jiing-Feng, AU - Lin,Ker-Neng, AU - Wu,Zin-An, Y1 - 2009/02/13/ PY - 2007/10/10/received PY - 2008/03/17/revised PY - 2008/05/07/accepted PY - 2009/2/17/entrez PY - 2009/2/17/pubmed PY - 2009/5/12/medline SP - 221 EP - 31 JF - Psychiatry research JO - Psychiatry Res VL - 171 IS - 3 N2 - Studies suggest that smaller hippocampal volume predicts Alzheimer's disease (AD) in mild cognitive impairment (MCI). However, few studies have demonstrated decline rates in cognition and hippocampal volume in MCI subjects with stable clinical presentation. Furthermore, the effects of apolipoprotein E (ApoE) on the change rates of medial temporal structures and cognition in MCI are rarely investigated. Fifty-eight subjects with amnestic MCI and 20 normal aging elderly controls received annual neuropsychological and magnetic resonance imaging (MRI) assessments. Annual decline rates in neuropsychological test scores, hippocampal and amygdalar volumes were calculated. ApoE genotypes were examined. Nineteen (32.7%) MCI subjects converted to AD during an average 22.5-month follow-up period. The annual hippocampal atrophy rate was correlated with a decline in memory test scores. The presence of the ApoE varepsilon4 allele did not affect the change rates in neuropsychological test scores and medial temporal structures volume. Compared to subjects with stable MCI (MCI-S) and normal aging, progressive MCI (MCI-P) had the highest annual decline rates in cognition and hippocampal volume. Logistic regression analysis showed that higher annual decline rates in hippocampal volume and global cognitive test scores were associated with conversion to AD. Furthermore, although MCI-S subjects had little cognitive decline, their hippocampal atrophy rates were higher than those of normal aging controls. Therefore, accelerated hippocampal atrophy rates may be an early and important presentation in MCI subjects. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/19217759/Accelerated_hippocampal_atrophy_rates_in_stable_and_progressive_amnestic_mild_cognitive_impairment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0925-4927(08)00071-1 DB - PRIME DP - Unbound Medicine ER -