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[Epidemiological features of invasive pneumococcal disease before and after the introduction of pneumococcal conjugate vaccine in Gran Canaria (Canary Islands)].
Enferm Infecc Microbiol Clin. 2009 Jan; 27(1):14-21.EI

Abstract

INTRODUCTION

The introduction of pneumococcal conjugate vaccine (PCV-7) has modified the epidemiology of invasive pneumococcal disease (IPD). Our aim was to investigate the epidemiological features of IPD before and after implementing the use of PCV-7.

METHODS

All invasive Streptococcus pneumoniae strains isolated in our hospital from 2000 to 2006 were included. Serotypes were identified and antibiograms were performed in all cases. Data obtained before (2000-2001) and after (2004-2006) authorization of PCV-7 use in Spain were compared.

RESULTS

There were 241 cases of IPD. None of the patients with IPD aged 2 years or younger had received PCV-7. PCV-7 coverage in children aged 5 or younger was about 48%. There was a non-significant increase in the incidence of IPD in children (from 53.8 to 57.8 cases/100 000 population), with no change in adults. When IPD incidence was adjusted by the number of blood samples collected, there was a non-significant decrease in both children and adults. Since PCV-7 came on the market, there has been a decrease in vaccine serotypes and an increase in non-vaccine serotypes. The emergent serotypes since that time include 3, 6A, 15, and 19A. Penicillin resistance decreased significantly (p<0.001) from the pre-vaccine period (87.3%) to 2003 (13.8%), and later rose from 2003 through 2006 (41.7%). Erythromycin resistance showed no changes during the study.

CONCLUSIONS

The incidence of IPD in children aged 2 years and younger in Gran Canaria has not decreased despite the introduction of PCV-7. However, there has been a reduction in the number of cases related to vaccine serotypes and a significant decrease in penicillin resistance. In contrast, non-vaccine serotype IPD cases have increased. Universal vaccination and the use of new polyvalent vaccines may enhance these effects.

Authors+Show Affiliations

Servicio de Microbiología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, España. fartcam@gobiernodecanarias.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

19217998

Citation

Artiles, Fernando, et al. "[Epidemiological Features of Invasive Pneumococcal Disease Before and After the Introduction of Pneumococcal Conjugate Vaccine in Gran Canaria (Canary Islands)]." Enfermedades Infecciosas Y Microbiologia Clinica, vol. 27, no. 1, 2009, pp. 14-21.
Artiles F, Horcajada I, Cañas AM, et al. [Epidemiological features of invasive pneumococcal disease before and after the introduction of pneumococcal conjugate vaccine in Gran Canaria (Canary Islands)]. Enferm Infecc Microbiol Clin. 2009;27(1):14-21.
Artiles, F., Horcajada, I., Cañas, A. M., Alamo, I., Bordes, A., González, A., Santana, M., & Lafarga, B. (2009). [Epidemiological features of invasive pneumococcal disease before and after the introduction of pneumococcal conjugate vaccine in Gran Canaria (Canary Islands)]. Enfermedades Infecciosas Y Microbiologia Clinica, 27(1), 14-21. https://doi.org/10.1016/j.eimc.2008.03.001
Artiles F, et al. [Epidemiological Features of Invasive Pneumococcal Disease Before and After the Introduction of Pneumococcal Conjugate Vaccine in Gran Canaria (Canary Islands)]. Enferm Infecc Microbiol Clin. 2009;27(1):14-21. PubMed PMID: 19217998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Epidemiological features of invasive pneumococcal disease before and after the introduction of pneumococcal conjugate vaccine in Gran Canaria (Canary Islands)]. AU - Artiles,Fernando, AU - Horcajada,Iballa, AU - Cañas,Ana María, AU - Alamo,Isabel, AU - Bordes,Ana, AU - González,Agustín, AU - Santana,Milagrosa, AU - Lafarga,Bernardo, Y1 - 2009/01/09/ PY - 2007/10/19/received PY - 2008/03/27/accepted PY - 2009/2/17/entrez PY - 2009/2/17/pubmed PY - 2009/5/22/medline SP - 14 EP - 21 JF - Enfermedades infecciosas y microbiologia clinica JO - Enferm Infecc Microbiol Clin VL - 27 IS - 1 N2 - INTRODUCTION: The introduction of pneumococcal conjugate vaccine (PCV-7) has modified the epidemiology of invasive pneumococcal disease (IPD). Our aim was to investigate the epidemiological features of IPD before and after implementing the use of PCV-7. METHODS: All invasive Streptococcus pneumoniae strains isolated in our hospital from 2000 to 2006 were included. Serotypes were identified and antibiograms were performed in all cases. Data obtained before (2000-2001) and after (2004-2006) authorization of PCV-7 use in Spain were compared. RESULTS: There were 241 cases of IPD. None of the patients with IPD aged 2 years or younger had received PCV-7. PCV-7 coverage in children aged 5 or younger was about 48%. There was a non-significant increase in the incidence of IPD in children (from 53.8 to 57.8 cases/100 000 population), with no change in adults. When IPD incidence was adjusted by the number of blood samples collected, there was a non-significant decrease in both children and adults. Since PCV-7 came on the market, there has been a decrease in vaccine serotypes and an increase in non-vaccine serotypes. The emergent serotypes since that time include 3, 6A, 15, and 19A. Penicillin resistance decreased significantly (p<0.001) from the pre-vaccine period (87.3%) to 2003 (13.8%), and later rose from 2003 through 2006 (41.7%). Erythromycin resistance showed no changes during the study. CONCLUSIONS: The incidence of IPD in children aged 2 years and younger in Gran Canaria has not decreased despite the introduction of PCV-7. However, there has been a reduction in the number of cases related to vaccine serotypes and a significant decrease in penicillin resistance. In contrast, non-vaccine serotype IPD cases have increased. Universal vaccination and the use of new polyvalent vaccines may enhance these effects. SN - 0213-005X UR - https://www.unboundmedicine.com/medline/citation/19217998/[Epidemiological_features_of_invasive_pneumococcal_disease_before_and_after_the_introduction_of_pneumococcal_conjugate_vaccine_in_Gran_Canaria__Canary_Islands_]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0213-005X(08)00007-4 DB - PRIME DP - Unbound Medicine ER -