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[Relationship between protein oxidation levels in the follicular fluid and the outcome parameters of in vitro fertilization-embryo transplantation].
Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jan; 29(1):160-3.NF

Abstract

OBJECTIVE

To explore the relationship between protein oxidation levels in the follicular fluid and the outcome parameters of in vitro fertilization-embryo transplantation (IVF-ET).

METHODS

The levels of advanced oxidation protein products (AOPP) in the follicular fluid were measured in 64 women with tubal infertility undergoing IVF-ET. The relationship between the AOPP levels and IVF-ET outcome parameters was analyzed.

RESULTS

AOPP levels showed significant inverse correlations between the proportion of mature oocytes (r=-0.401, P=0.001), fertilization rate (r=-0.257, P=0.045), cleavage rate (r=-0.290, P=0.024) and good embryo rate (r=-0.520, P=0.000). AOPP levels differed significantly between the groups with different retrieved oocyte numbers (F=3.851, P=0.027), being the lowest in women with 8 to 15 retrieved oocytes and the highest in those with retrieved oocytes below 8. The AOPP level in the non-pregnant women was significantly higher than that in the pregnant women (t=3.665, P=0.001). The AOPP levels also differed significantly with age (F=15.919, P=0.000), and the women >35 years of age had the highest level and those below 30 years had the lowest level.

CONCLUSION

Protein oxidative stress is present in the follicular fluid of women on IVF-ET cycles. High level of AOPP may have adverse effects on the oocytes and early embryonic development and may affect the outcome of IVF-ET.

Authors+Show Affiliations

Reproductive Technology Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. syl950446@126.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

19218140

Citation

Song, Ya-li, et al. "[Relationship Between Protein Oxidation Levels in the Follicular Fluid and the Outcome Parameters of in Vitro Fertilization-embryo Transplantation]." Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, vol. 29, no. 1, 2009, pp. 160-3.
Song YL, Quan S, Tian JW, et al. [Relationship between protein oxidation levels in the follicular fluid and the outcome parameters of in vitro fertilization-embryo transplantation]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29(1):160-3.
Song, Y. L., Quan, S., Tian, J. W., Li, H., Chen, S. M., & Xing, F. Q. (2009). [Relationship between protein oxidation levels in the follicular fluid and the outcome parameters of in vitro fertilization-embryo transplantation]. Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, 29(1), 160-3.
Song YL, et al. [Relationship Between Protein Oxidation Levels in the Follicular Fluid and the Outcome Parameters of in Vitro Fertilization-embryo Transplantation]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29(1):160-3. PubMed PMID: 19218140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Relationship between protein oxidation levels in the follicular fluid and the outcome parameters of in vitro fertilization-embryo transplantation]. AU - Song,Ya-li, AU - Quan,Song, AU - Tian,Jian-wei, AU - Li,Hong, AU - Chen,Si-mei, AU - Xing,Fu-qi, PY - 2009/2/17/entrez PY - 2009/2/17/pubmed PY - 2010/4/30/medline SP - 160 EP - 3 JF - Nan fang yi ke da xue xue bao = Journal of Southern Medical University JO - Nan Fang Yi Ke Da Xue Xue Bao VL - 29 IS - 1 N2 - OBJECTIVE: To explore the relationship between protein oxidation levels in the follicular fluid and the outcome parameters of in vitro fertilization-embryo transplantation (IVF-ET). METHODS: The levels of advanced oxidation protein products (AOPP) in the follicular fluid were measured in 64 women with tubal infertility undergoing IVF-ET. The relationship between the AOPP levels and IVF-ET outcome parameters was analyzed. RESULTS: AOPP levels showed significant inverse correlations between the proportion of mature oocytes (r=-0.401, P=0.001), fertilization rate (r=-0.257, P=0.045), cleavage rate (r=-0.290, P=0.024) and good embryo rate (r=-0.520, P=0.000). AOPP levels differed significantly between the groups with different retrieved oocyte numbers (F=3.851, P=0.027), being the lowest in women with 8 to 15 retrieved oocytes and the highest in those with retrieved oocytes below 8. The AOPP level in the non-pregnant women was significantly higher than that in the pregnant women (t=3.665, P=0.001). The AOPP levels also differed significantly with age (F=15.919, P=0.000), and the women >35 years of age had the highest level and those below 30 years had the lowest level. CONCLUSION: Protein oxidative stress is present in the follicular fluid of women on IVF-ET cycles. High level of AOPP may have adverse effects on the oocytes and early embryonic development and may affect the outcome of IVF-ET. SN - 1673-4254 UR - https://www.unboundmedicine.com/medline/citation/19218140/[Relationship_between_protein_oxidation_levels_in_the_follicular_fluid_and_the_outcome_parameters_of_in_vitro_fertilization_embryo_transplantation]_ L2 - http://www.diseaseinfosearch.org/result/7171 DB - PRIME DP - Unbound Medicine ER -