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Upregulation of Th1 cytokine profile in bronchoalveolar lavage fluid of patients with hypersensitivity pneumonitis.
J Physiol Pharmacol. 2008 Dec; 59 Suppl 6:499-505.JP

Abstract

The aim was to find out how the IL-12 and IL-18 levels in the bronchoalveolar lavage fluid (BALF) correspond to the inflammatory activity of the hypersensitivity pneumonitis (HP). We studied 12 patients with HP and 13 normal subjects. IL-12 and IL-18 levels were measured using ELISA kits. We found a significantly higher plasma angiotensin-converting enzyme (ACE) concentration (55 vs. 34 U/L, P=0.0016), lymphocyte percentage (57 vs. 14%, P<0.001), CD8+ cells (32 vs. 17%, P<0.001) and a lower CD4/CD8 ratio (1.2 vs. 2.0, P<0.0001). The IL-12 and IL-18 levels in BALF were significantly higher in HP patients than in healthy subjects (3.9 vs. 3.2 pg/ml, P=0.003 and 14.2 vs. 6.15 pg/ml, P% 0.0001, respectively). We found a strong positive correlation between IL-12 and the percentage of lymphocytes (r=0.68, P=0.015) and a negative one between IL-12 and the percentage of macrophages in BALF (r=-0.64, P=0.024). We conclude that upregulation of the Th1 cell cytokine profile may play a significant role in the pathogenesis of HP.

Authors+Show Affiliations

Department of Pneumology, Bialystok Medical University, Bialystok, Poland. robmroz@wp.plNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19218674

Citation

Mroz, R M., et al. "Upregulation of Th1 Cytokine Profile in Bronchoalveolar Lavage Fluid of Patients With Hypersensitivity Pneumonitis." Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, vol. 59 Suppl 6, 2008, pp. 499-505.
Mroz RM, Korniluk M, Stasiak-Barmuta A, et al. Upregulation of Th1 cytokine profile in bronchoalveolar lavage fluid of patients with hypersensitivity pneumonitis. J Physiol Pharmacol. 2008;59 Suppl 6:499-505.
Mroz, R. M., Korniluk, M., Stasiak-Barmuta, A., & Chyczewska, E. (2008). Upregulation of Th1 cytokine profile in bronchoalveolar lavage fluid of patients with hypersensitivity pneumonitis. Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, 59 Suppl 6, 499-505.
Mroz RM, et al. Upregulation of Th1 Cytokine Profile in Bronchoalveolar Lavage Fluid of Patients With Hypersensitivity Pneumonitis. J Physiol Pharmacol. 2008;59 Suppl 6:499-505. PubMed PMID: 19218674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Upregulation of Th1 cytokine profile in bronchoalveolar lavage fluid of patients with hypersensitivity pneumonitis. AU - Mroz,R M, AU - Korniluk,M, AU - Stasiak-Barmuta,A, AU - Chyczewska,E, PY - 2008/08/08/received PY - 2008/08/20/accepted PY - 2009/2/17/entrez PY - 2009/2/28/pubmed PY - 2009/4/18/medline SP - 499 EP - 505 JF - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JO - J Physiol Pharmacol VL - 59 Suppl 6 N2 - The aim was to find out how the IL-12 and IL-18 levels in the bronchoalveolar lavage fluid (BALF) correspond to the inflammatory activity of the hypersensitivity pneumonitis (HP). We studied 12 patients with HP and 13 normal subjects. IL-12 and IL-18 levels were measured using ELISA kits. We found a significantly higher plasma angiotensin-converting enzyme (ACE) concentration (55 vs. 34 U/L, P=0.0016), lymphocyte percentage (57 vs. 14%, P<0.001), CD8+ cells (32 vs. 17%, P<0.001) and a lower CD4/CD8 ratio (1.2 vs. 2.0, P<0.0001). The IL-12 and IL-18 levels in BALF were significantly higher in HP patients than in healthy subjects (3.9 vs. 3.2 pg/ml, P=0.003 and 14.2 vs. 6.15 pg/ml, P% 0.0001, respectively). We found a strong positive correlation between IL-12 and the percentage of lymphocytes (r=0.68, P=0.015) and a negative one between IL-12 and the percentage of macrophages in BALF (r=-0.64, P=0.024). We conclude that upregulation of the Th1 cell cytokine profile may play a significant role in the pathogenesis of HP. SN - 1899-1505 UR - https://www.unboundmedicine.com/medline/citation/19218674/Upregulation_of_Th1_cytokine_profile_in_bronchoalveolar_lavage_fluid_of_patients_with_hypersensitivity_pneumonitis_ L2 - https://antibodies.cancer.gov/detail/CPTC-IL18-4 DB - PRIME DP - Unbound Medicine ER -