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Increased levels of interleukin-12 and interleukin-18 in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis.
J Physiol Pharmacol. 2008 Dec; 59 Suppl 6:507-13.JP

Abstract

We studied prospectively 43 patients with sarcoidosis and 13 normal subjects. IL-12 and IL-18 levels were measured using ELISA kits. Spirometry and body plethysmography were performed using an Elite DL Medgraphics body box. The sarcoidosis group was characterized by significantly higher median range of the plasma angiotensin-converting enzyme (ACE) concentration (72 vs. 34 U/l, P<0.0001), lymphocyte (34 vs. 14%, P<0.0001), CD4+ cells percentages (59 vs. 36%), and CD4/CD8 ratio (4.2 vs. 1.99, P<0.0001). The BALF IL-12 and IL-18 levels were significantly higher in sarcoidosis patients than in healthy subjects (4.1 pg/ml vs. 3.2 pg/ml; P<0.001 and 11.1 pg/ml vs. 6.15 pg/ml, P<0.0001, respectively). A negative correlation between BALF IL-12 and ACE plasma levels (r=-0.33, P<0.05) within the sarcoidosis group was found. Our data suggest a potential role of IL-12 and IL-18 in a local immunologic response in pulmonary sarcoidosis.

Authors+Show Affiliations

Department of Pneumology, Bialystok Medical University, Bialystok, Poland. robmroz@wp.plNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19218675

Citation

Mroz, R M., et al. "Increased Levels of Interleukin-12 and Interleukin-18 in Bronchoalveolar Lavage Fluid of Patients With Pulmonary Sarcoidosis." Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, vol. 59 Suppl 6, 2008, pp. 507-13.
Mroz RM, Korniluk M, Stasiak-Barmuta A, et al. Increased levels of interleukin-12 and interleukin-18 in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis. J Physiol Pharmacol. 2008;59 Suppl 6:507-13.
Mroz, R. M., Korniluk, M., Stasiak-Barmuta, A., & Chyczewska, E. (2008). Increased levels of interleukin-12 and interleukin-18 in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis. Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, 59 Suppl 6, 507-13.
Mroz RM, et al. Increased Levels of Interleukin-12 and Interleukin-18 in Bronchoalveolar Lavage Fluid of Patients With Pulmonary Sarcoidosis. J Physiol Pharmacol. 2008;59 Suppl 6:507-13. PubMed PMID: 19218675.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased levels of interleukin-12 and interleukin-18 in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis. AU - Mroz,R M, AU - Korniluk,M, AU - Stasiak-Barmuta,A, AU - Chyczewska,E, PY - 2008/08/08/received PY - 2008/08/22/accepted PY - 2009/2/17/entrez PY - 2009/2/28/pubmed PY - 2009/4/18/medline SP - 507 EP - 13 JF - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JO - J Physiol Pharmacol VL - 59 Suppl 6 N2 - We studied prospectively 43 patients with sarcoidosis and 13 normal subjects. IL-12 and IL-18 levels were measured using ELISA kits. Spirometry and body plethysmography were performed using an Elite DL Medgraphics body box. The sarcoidosis group was characterized by significantly higher median range of the plasma angiotensin-converting enzyme (ACE) concentration (72 vs. 34 U/l, P<0.0001), lymphocyte (34 vs. 14%, P<0.0001), CD4+ cells percentages (59 vs. 36%), and CD4/CD8 ratio (4.2 vs. 1.99, P<0.0001). The BALF IL-12 and IL-18 levels were significantly higher in sarcoidosis patients than in healthy subjects (4.1 pg/ml vs. 3.2 pg/ml; P<0.001 and 11.1 pg/ml vs. 6.15 pg/ml, P<0.0001, respectively). A negative correlation between BALF IL-12 and ACE plasma levels (r=-0.33, P<0.05) within the sarcoidosis group was found. Our data suggest a potential role of IL-12 and IL-18 in a local immunologic response in pulmonary sarcoidosis. SN - 1899-1505 UR - https://www.unboundmedicine.com/medline/citation/19218675/Increased_levels_of_interleukin_12_and_interleukin_18_in_bronchoalveolar_lavage_fluid_of_patients_with_pulmonary_sarcoidosis_ L2 - http://www.diseaseinfosearch.org/result/6412 DB - PRIME DP - Unbound Medicine ER -