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Placental 11beta-HSD2 gene expression at birth is inversely correlated with growth velocity in the first year of life after intrauterine growth restriction.
Pediatr Res 2009; 65(6):647-53PR

Abstract

Intrauterine growth restriction (IUGR) is associated with an increased risk for short stature and diseases in adulthood thought to be inflicted by fetal programming. We hypothesized that placental endocrine systems involved in perinatal growth might also play a role in postnatal growth after IUGR. In a prospective controlled multicenter study, placental gene expression of IGF-binding protein-1 (IGFBP-1), leptin and 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) were measured in 14 IUGR infants and 15 children born appropriate for gestational age (AGA) proven by serial ultrasound examinations. Postnatally, IUGR infants experienced a significantly higher growth velocity than AGA neonates (at 1 y: p = 0.001). Gene expression of 11beta-HSD2 at birth correlated positively with birth length (r = 0.55, p = 0.04) and inversely with growth velocity in the first year of life (r = -0.69, p = 0.01) in the IUGR, but not in the AGA group. There was no correlation between gene expression of placental IGFBP-1, leptin and birth weight, length and growth velocity during the first year of life. AGA infants showed significantly higher concentrations of cortisone in venous cord blood after birth (p = 0.02) as a surrogate of a higher 11beta-HSD2 activity in the fetoplacental unit. In conclusion, placental 11beta-HSD2 gene expression might predict postnatal growth in IUGR.

Authors+Show Affiliations

Department of Paediatrics and Adolescent Medicine, University of Erlangen-Nuremberg, Erlangen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19218882

Citation

Tzschoppe, Anja, et al. "Placental 11beta-HSD2 Gene Expression at Birth Is Inversely Correlated With Growth Velocity in the First Year of Life After Intrauterine Growth Restriction." Pediatric Research, vol. 65, no. 6, 2009, pp. 647-53.
Tzschoppe A, Struwe E, Blessing H, et al. Placental 11beta-HSD2 gene expression at birth is inversely correlated with growth velocity in the first year of life after intrauterine growth restriction. Pediatr Res. 2009;65(6):647-53.
Tzschoppe, A., Struwe, E., Blessing, H., Fahlbusch, F., Liebhaber, G., Dörr, H. G., ... Dötsch, J. (2009). Placental 11beta-HSD2 gene expression at birth is inversely correlated with growth velocity in the first year of life after intrauterine growth restriction. Pediatric Research, 65(6), pp. 647-53. doi:10.1203/PDR.0b013e31819e7337.
Tzschoppe A, et al. Placental 11beta-HSD2 Gene Expression at Birth Is Inversely Correlated With Growth Velocity in the First Year of Life After Intrauterine Growth Restriction. Pediatr Res. 2009;65(6):647-53. PubMed PMID: 19218882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Placental 11beta-HSD2 gene expression at birth is inversely correlated with growth velocity in the first year of life after intrauterine growth restriction. AU - Tzschoppe,Anja, AU - Struwe,Ellen, AU - Blessing,Holger, AU - Fahlbusch,Fabian, AU - Liebhaber,Gisela, AU - Dörr,Helmuth G, AU - Rauh,Manfred, AU - Rascher,Wolfgang, AU - Goecke,Tamme W, AU - Schild,Ralf L, AU - Schleussner,Ekkehard, AU - Scheler,Cerrie, AU - Hübler,Axel, AU - Dahlem,Peter, AU - Dötsch,Jörg, PY - 2009/2/17/entrez PY - 2009/2/17/pubmed PY - 2009/8/18/medline SP - 647 EP - 53 JF - Pediatric research JO - Pediatr. Res. VL - 65 IS - 6 N2 - Intrauterine growth restriction (IUGR) is associated with an increased risk for short stature and diseases in adulthood thought to be inflicted by fetal programming. We hypothesized that placental endocrine systems involved in perinatal growth might also play a role in postnatal growth after IUGR. In a prospective controlled multicenter study, placental gene expression of IGF-binding protein-1 (IGFBP-1), leptin and 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) were measured in 14 IUGR infants and 15 children born appropriate for gestational age (AGA) proven by serial ultrasound examinations. Postnatally, IUGR infants experienced a significantly higher growth velocity than AGA neonates (at 1 y: p = 0.001). Gene expression of 11beta-HSD2 at birth correlated positively with birth length (r = 0.55, p = 0.04) and inversely with growth velocity in the first year of life (r = -0.69, p = 0.01) in the IUGR, but not in the AGA group. There was no correlation between gene expression of placental IGFBP-1, leptin and birth weight, length and growth velocity during the first year of life. AGA infants showed significantly higher concentrations of cortisone in venous cord blood after birth (p = 0.02) as a surrogate of a higher 11beta-HSD2 activity in the fetoplacental unit. In conclusion, placental 11beta-HSD2 gene expression might predict postnatal growth in IUGR. SN - 1530-0447 UR - https://www.unboundmedicine.com/medline/citation/19218882/Placental_11beta_HSD2_gene_expression_at_birth_is_inversely_correlated_with_growth_velocity_in_the_first_year_of_life_after_intrauterine_growth_restriction_ L2 - http://dx.doi.org/10.1203/PDR.0b013e31819e7337 DB - PRIME DP - Unbound Medicine ER -