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Scrub typhus: the geographic distribution of phenotypic and genotypic variants of Orientia tsutsugamushi.
Clin Infect Dis. 2009 Mar 15; 48 Suppl 3:S203-30.CI

Abstract

Orientia tsutsugamushi is the etiological agent of scrub typhus, an acute, mite-borne, febrile illness that occurs in the Asia-Pacific region. Historically, strain characterization used serological analysis and revealed dramatic antigenic diversity. Eyeing a recommendation of potential vaccine candidates for broad protection, we review geographic diversity and serological and DNA prevalences. DNA analysis together with immunological analysis suggest that the prototype Karp strain and closely related strains are the most common throughout the region of endemicity. According to serological analysis, approximately 50% of isolates are seroreactive to Karp antisera, and approximately one-quarter of isolates are seroreactive to antisera against the prototype Gilliam strain. Molecular methods reveal greater diversity. By molecular methods, strains phylogenetically similar to Karp make up approximately 40% of all genotyped isolates, followed by the JG genotype group (Japan strains serotypically similar to the Gilliam strain but genetically non-Gilliam; 18% of all genotyped isolates). Three other genotype groups (Kato-related, Kawasaki-like, and TA763-like) each represent approximately 10% of genotyped isolates. Strains genetically similar to the Gilliam strain make up only 5% of isolates. Strains from these groups should be included in any potential vaccine.

Authors+Show Affiliations

Department of Evolution, Ecology, and Organismal Biology, The Ohio State University, Columbus, OH 43210, USA. Kelly.350@osu.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

19220144

Citation

Kelly, Daryl J., et al. "Scrub Typhus: the Geographic Distribution of Phenotypic and Genotypic Variants of Orientia Tsutsugamushi." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 48 Suppl 3, 2009, pp. S203-30.
Kelly DJ, Fuerst PA, Ching WM, et al. Scrub typhus: the geographic distribution of phenotypic and genotypic variants of Orientia tsutsugamushi. Clin Infect Dis. 2009;48 Suppl 3:S203-30.
Kelly, D. J., Fuerst, P. A., Ching, W. M., & Richards, A. L. (2009). Scrub typhus: the geographic distribution of phenotypic and genotypic variants of Orientia tsutsugamushi. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 48 Suppl 3, S203-30. https://doi.org/10.1086/596576
Kelly DJ, et al. Scrub Typhus: the Geographic Distribution of Phenotypic and Genotypic Variants of Orientia Tsutsugamushi. Clin Infect Dis. 2009 Mar 15;48 Suppl 3:S203-30. PubMed PMID: 19220144.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Scrub typhus: the geographic distribution of phenotypic and genotypic variants of Orientia tsutsugamushi. AU - Kelly,Daryl J, AU - Fuerst,Paul A, AU - Ching,Wei-Mei, AU - Richards,Allen L, PY - 2009/2/18/entrez PY - 2009/2/28/pubmed PY - 2009/3/19/medline SP - S203 EP - 30 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 48 Suppl 3 N2 - Orientia tsutsugamushi is the etiological agent of scrub typhus, an acute, mite-borne, febrile illness that occurs in the Asia-Pacific region. Historically, strain characterization used serological analysis and revealed dramatic antigenic diversity. Eyeing a recommendation of potential vaccine candidates for broad protection, we review geographic diversity and serological and DNA prevalences. DNA analysis together with immunological analysis suggest that the prototype Karp strain and closely related strains are the most common throughout the region of endemicity. According to serological analysis, approximately 50% of isolates are seroreactive to Karp antisera, and approximately one-quarter of isolates are seroreactive to antisera against the prototype Gilliam strain. Molecular methods reveal greater diversity. By molecular methods, strains phylogenetically similar to Karp make up approximately 40% of all genotyped isolates, followed by the JG genotype group (Japan strains serotypically similar to the Gilliam strain but genetically non-Gilliam; 18% of all genotyped isolates). Three other genotype groups (Kato-related, Kawasaki-like, and TA763-like) each represent approximately 10% of genotyped isolates. Strains genetically similar to the Gilliam strain make up only 5% of isolates. Strains from these groups should be included in any potential vaccine. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/19220144/Scrub_typhus:_the_geographic_distribution_of_phenotypic_and_genotypic_variants_of_Orientia_tsutsugamushi_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/596576 DB - PRIME DP - Unbound Medicine ER -