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GLP-1 regulates gastroduodenal motility involving cholinergic pathways.
Neurogastroenterol Motil. 2009 Jun; 21(6):609-18, e21-2.NM

Abstract

The gut-born incretin hormone glucagon-like peptide-1 (GLP-1) delays gastric emptying. To elucidate the mechanisms by which GLP-1 affects gastroduodenal motility and glycaemia, we studied the effects of exendin(9-39), a potent GLP-1 receptor antagonist, on gastroduodenal motility and pancreatic hormones. In this randomized, double-blind, placebo-controlled, four-arm, cross-over trial, 10 healthy volunteers were studied during the interdigestive period followed by duodenal perfusion of a mixed liquid meal (250 kcal). On four separate days, exendin(9-39), atropine, exendin(9-39) + atropine or saline were infused intravenously. Antro-pyloro-duodenal and fundic motility were assessed. The compliance of the proximal stomach was determined by isobaric distensions. During fasting, exendin(9-39) did not influence proximal gastric volume, pyloric tone, and duodenal contractility. Exendin(9-39) significantly increased antral waves only in the absence of atropine. During duodenal meal perfusion, exendin(9-39) significantly reduced proximal gastric volume accommodation, abbreviated postprandial antral inhibition, reduced the postprandial increase in pyloric tone, and reduced gastric compliance. Atropine abolished the effects of exendin(9-39) on gastric volume accommodation but did not affect its effects on postprandial antroduodenal motility and on gastric compliance. Exendin(9-39) increased fasting and postprandial glycaemia and plasma glucagon but not insulin concentrations. Atropine did not affect GLP-1 secretion. Cholinergic mechanisms mediate the effects of GLP-1 on postprandial gastric accommodation but not on antro-pyloro-duodenal motility. GLP-1 reduces fasting and postprandial glycaemia, in part by reducing glucagon secretion.

Authors+Show Affiliations

Department of Internal Medicine II, Ludwig-Maximilians University, Munich, Germany. joerg.schirra@med.uni-muenchen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19220754

Citation

Schirra, J, et al. "GLP-1 Regulates Gastroduodenal Motility Involving Cholinergic Pathways." Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, vol. 21, no. 6, 2009, pp. 609-18, e21-2.
Schirra J, Nicolaus M, Woerle HJ, et al. GLP-1 regulates gastroduodenal motility involving cholinergic pathways. Neurogastroenterol Motil. 2009;21(6):609-18, e21-2.
Schirra, J., Nicolaus, M., Woerle, H. J., Struckmeier, C., Katschinski, M., & Göke, B. (2009). GLP-1 regulates gastroduodenal motility involving cholinergic pathways. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, 21(6), 609-18, e21-2. https://doi.org/10.1111/j.1365-2982.2008.01246.x
Schirra J, et al. GLP-1 Regulates Gastroduodenal Motility Involving Cholinergic Pathways. Neurogastroenterol Motil. 2009;21(6):609-18, e21-2. PubMed PMID: 19220754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - GLP-1 regulates gastroduodenal motility involving cholinergic pathways. AU - Schirra,J, AU - Nicolaus,M, AU - Woerle,H J, AU - Struckmeier,C, AU - Katschinski,M, AU - Göke,B, Y1 - 2009/02/06/ PY - 2009/2/18/entrez PY - 2009/2/18/pubmed PY - 2009/11/3/medline SP - 609-18, e21-2 JF - Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society JO - Neurogastroenterol Motil VL - 21 IS - 6 N2 - The gut-born incretin hormone glucagon-like peptide-1 (GLP-1) delays gastric emptying. To elucidate the mechanisms by which GLP-1 affects gastroduodenal motility and glycaemia, we studied the effects of exendin(9-39), a potent GLP-1 receptor antagonist, on gastroduodenal motility and pancreatic hormones. In this randomized, double-blind, placebo-controlled, four-arm, cross-over trial, 10 healthy volunteers were studied during the interdigestive period followed by duodenal perfusion of a mixed liquid meal (250 kcal). On four separate days, exendin(9-39), atropine, exendin(9-39) + atropine or saline were infused intravenously. Antro-pyloro-duodenal and fundic motility were assessed. The compliance of the proximal stomach was determined by isobaric distensions. During fasting, exendin(9-39) did not influence proximal gastric volume, pyloric tone, and duodenal contractility. Exendin(9-39) significantly increased antral waves only in the absence of atropine. During duodenal meal perfusion, exendin(9-39) significantly reduced proximal gastric volume accommodation, abbreviated postprandial antral inhibition, reduced the postprandial increase in pyloric tone, and reduced gastric compliance. Atropine abolished the effects of exendin(9-39) on gastric volume accommodation but did not affect its effects on postprandial antroduodenal motility and on gastric compliance. Exendin(9-39) increased fasting and postprandial glycaemia and plasma glucagon but not insulin concentrations. Atropine did not affect GLP-1 secretion. Cholinergic mechanisms mediate the effects of GLP-1 on postprandial gastric accommodation but not on antro-pyloro-duodenal motility. GLP-1 reduces fasting and postprandial glycaemia, in part by reducing glucagon secretion. SN - 1365-2982 UR - https://www.unboundmedicine.com/medline/citation/19220754/GLP_1_regulates_gastroduodenal_motility_involving_cholinergic_pathways_ L2 - https://doi.org/10.1111/j.1365-2982.2008.01246.x DB - PRIME DP - Unbound Medicine ER -