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Usual interstitial pneumonia and nonspecific interstitial pneumonia with and without concurrent emphysema: thin-section CT findings.
Radiology. 2009 Apr; 251(1):271-9.R

Abstract

PURPOSE

To determine whether concurrent emphysema influences the distinction between usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP) at thin-section computed tomography (CT).

MATERIALS AND METHODS

Institutional review board approval was obtained for this retrospective study; informed consent was not required. The study included 54 patients with NSIP and 42 patients with UIP (55 men, 41 women; mean age, 60.2 years +/- 9.2 [standard deviation]; age range, 33-77 years). Two independent readers assessed the CT images and made a first-choice diagnosis. The appearances of UIP and NSIP at CT were compared with univariate and multivariate analyses. Receiver operating characteristic curves were used to determine how concurrent emphysema influences the distinction of UIP from NSIP at thin-section CT.

RESULTS

The diagnosis was correct in 136 (71%) of 192 readings. In patients with concurrent emphysema, the diagnosis was correct in 30 (44%) of 68 readings. Sensitivity, specificity, and accuracy for diagnosis were lower in patients with concurrent emphysema than in patients without concurrent emphysema. In patients with concurrent emphysema, there were no significant differences in extent of fibrosis, extent of honeycombing, extent of consolidation, coarseness of fibrosis score, extent of traction bronchiectasis, upper lung irregular lines, peribronchovascular distribution, and nodules between UIP and NSIP. According to multivariate analysis, the CT feature that helped best differentiate UIP from NSIP in patients with emphysema was traction bronchiolectasis.

CONCLUSION

Concurrent emphysema influenced the distinction between UIP and NSIP.

Authors+Show Affiliations

Department of Radiology, National Hospital Organization, Kinki-Chuo Chest Medical Center, 1180 Nagasone-cho, Kita-ku, Sakai City, Osaka 591-8555, Japan. akira@kch.hosp.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

19221055

Citation

Akira, Masanori, et al. "Usual Interstitial Pneumonia and Nonspecific Interstitial Pneumonia With and Without Concurrent Emphysema: Thin-section CT Findings." Radiology, vol. 251, no. 1, 2009, pp. 271-9.
Akira M, Inoue Y, Kitaichi M, et al. Usual interstitial pneumonia and nonspecific interstitial pneumonia with and without concurrent emphysema: thin-section CT findings. Radiology. 2009;251(1):271-9.
Akira, M., Inoue, Y., Kitaichi, M., Yamamoto, S., Arai, T., & Toyokawa, K. (2009). Usual interstitial pneumonia and nonspecific interstitial pneumonia with and without concurrent emphysema: thin-section CT findings. Radiology, 251(1), 271-9. https://doi.org/10.1148/radiol.2511080917
Akira M, et al. Usual Interstitial Pneumonia and Nonspecific Interstitial Pneumonia With and Without Concurrent Emphysema: Thin-section CT Findings. Radiology. 2009;251(1):271-9. PubMed PMID: 19221055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Usual interstitial pneumonia and nonspecific interstitial pneumonia with and without concurrent emphysema: thin-section CT findings. AU - Akira,Masanori, AU - Inoue,Yoshikazu, AU - Kitaichi,Masanori, AU - Yamamoto,Satoru, AU - Arai,Toru, AU - Toyokawa,Kazushige, Y1 - 2009/02/12/ PY - 2009/2/18/entrez PY - 2009/2/18/pubmed PY - 2009/4/23/medline SP - 271 EP - 9 JF - Radiology JO - Radiology VL - 251 IS - 1 N2 - PURPOSE: To determine whether concurrent emphysema influences the distinction between usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP) at thin-section computed tomography (CT). MATERIALS AND METHODS: Institutional review board approval was obtained for this retrospective study; informed consent was not required. The study included 54 patients with NSIP and 42 patients with UIP (55 men, 41 women; mean age, 60.2 years +/- 9.2 [standard deviation]; age range, 33-77 years). Two independent readers assessed the CT images and made a first-choice diagnosis. The appearances of UIP and NSIP at CT were compared with univariate and multivariate analyses. Receiver operating characteristic curves were used to determine how concurrent emphysema influences the distinction of UIP from NSIP at thin-section CT. RESULTS: The diagnosis was correct in 136 (71%) of 192 readings. In patients with concurrent emphysema, the diagnosis was correct in 30 (44%) of 68 readings. Sensitivity, specificity, and accuracy for diagnosis were lower in patients with concurrent emphysema than in patients without concurrent emphysema. In patients with concurrent emphysema, there were no significant differences in extent of fibrosis, extent of honeycombing, extent of consolidation, coarseness of fibrosis score, extent of traction bronchiectasis, upper lung irregular lines, peribronchovascular distribution, and nodules between UIP and NSIP. According to multivariate analysis, the CT feature that helped best differentiate UIP from NSIP in patients with emphysema was traction bronchiolectasis. CONCLUSION: Concurrent emphysema influenced the distinction between UIP and NSIP. SN - 1527-1315 UR - https://www.unboundmedicine.com/medline/citation/19221055/Usual_interstitial_pneumonia_and_nonspecific_interstitial_pneumonia_with_and_without_concurrent_emphysema:_thin_section_CT_findings_ L2 - https://pubs.rsna.org/doi/10.1148/radiol.2511080917?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -