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Lung disease caused by exposure to coal mine and silica dust.
Semin Respir Crit Care Med 2008; 29(6):651-61SR

Abstract

Susceptible workers exposed to coal mine and silica dust may develop a variety of pulmonary diseases. The prime example is classical pneumoconiosis, a nodular interstitial lung disease that, in severe cases, may lead to progressive massive fibrosis (PMF) . Exposure to silica and coal mine dusts may also result in pulmonary scarring in a pattern that mimics idiopathic pulmonary fibrosis, and in chronic obstructive pulmonary disease (COPD), including emphysema and chronic bronchitis, that appears indistinguishable from obstructive lung disease caused by exposure to tobacco smoke. Coal mine and silica dust may therefore result in restrictive, obstructive, or mixed patterns of impairment on pulmonary function testing. Most physicians are aware of the nodular fibrosing pulmonary tissue reactions in response to retained dust, but they may not realize that these other reactions of the pulmonary parenchyma and airways to dust exist and can result in significant respiratory dysfunction in sensitive individuals. This article discusses current data on exposure to coal mine and silica dust in the United States, the epidemiology of the diseases caused by these exposures, and new concepts of causation and pathogenesis. We also review the patterns of pulmonary disease and impairment that may result.

Authors+Show Affiliations

Department of Environmental and Occupational Health Sciences, University of Illinois School of Public Health, Chicago, USA. bobcohen@uic.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19221963

Citation

Cohen, Robert A C., et al. "Lung Disease Caused By Exposure to Coal Mine and Silica Dust." Seminars in Respiratory and Critical Care Medicine, vol. 29, no. 6, 2008, pp. 651-61.
Cohen RA, Patel A, Green FH. Lung disease caused by exposure to coal mine and silica dust. Semin Respir Crit Care Med. 2008;29(6):651-61.
Cohen, R. A., Patel, A., & Green, F. H. (2008). Lung disease caused by exposure to coal mine and silica dust. Seminars in Respiratory and Critical Care Medicine, 29(6), pp. 651-61. doi:10.1055/s-0028-1101275.
Cohen RA, Patel A, Green FH. Lung Disease Caused By Exposure to Coal Mine and Silica Dust. Semin Respir Crit Care Med. 2008;29(6):651-61. PubMed PMID: 19221963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lung disease caused by exposure to coal mine and silica dust. AU - Cohen,Robert A C, AU - Patel,Aiyub, AU - Green,Francis H Y, Y1 - 2009/02/16/ PY - 2009/2/18/entrez PY - 2009/2/18/pubmed PY - 2009/3/26/medline SP - 651 EP - 61 JF - Seminars in respiratory and critical care medicine JO - Semin Respir Crit Care Med VL - 29 IS - 6 N2 - Susceptible workers exposed to coal mine and silica dust may develop a variety of pulmonary diseases. The prime example is classical pneumoconiosis, a nodular interstitial lung disease that, in severe cases, may lead to progressive massive fibrosis (PMF) . Exposure to silica and coal mine dusts may also result in pulmonary scarring in a pattern that mimics idiopathic pulmonary fibrosis, and in chronic obstructive pulmonary disease (COPD), including emphysema and chronic bronchitis, that appears indistinguishable from obstructive lung disease caused by exposure to tobacco smoke. Coal mine and silica dust may therefore result in restrictive, obstructive, or mixed patterns of impairment on pulmonary function testing. Most physicians are aware of the nodular fibrosing pulmonary tissue reactions in response to retained dust, but they may not realize that these other reactions of the pulmonary parenchyma and airways to dust exist and can result in significant respiratory dysfunction in sensitive individuals. This article discusses current data on exposure to coal mine and silica dust in the United States, the epidemiology of the diseases caused by these exposures, and new concepts of causation and pathogenesis. We also review the patterns of pulmonary disease and impairment that may result. SN - 1098-9048 UR - https://www.unboundmedicine.com/medline/citation/19221963/Lung_disease_caused_by_exposure_to_coal_mine_and_silica_dust_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0028-1101275 DB - PRIME DP - Unbound Medicine ER -