Tags

Type your tag names separated by a space and hit enter

Non-alcoholic fatty liver disease pathogenesis: the present and the future.
Dig Liver Dis. 2009 Sep; 41(9):615-25.DL

Abstract

Non-alcoholic fatty liver disease is the clinical hepatic expression of metabolic syndrome. The prevalence of non-alcoholic fatty liver disease is around 20-30%, and with a rapid increase in the metabolic risk factors in the general population, non-alcoholic fatty liver disease has become the most common cause of liver disease worldwide. A fraction (20-30%) of non-alcoholic fatty liver disease patients develop a potentially progressive hepatic disorder, namely non-alcoholic steatohepatitis, leading to end-stage liver disease. The pathogenesis of non-alcoholic fatty liver disease is not entirely understood, and even if insulin resistance is a major pathogenetic key, many other factors are implicated in both liver fat accumulation and disease progression to non-alcoholic steatohepatitis. In this review we aim to examine the literature, principally concerning human non-alcoholic fatty liver disease pathogenesis, and to identify the newest, most promising clinical and basic research data.

Authors+Show Affiliations

Cattedra & Unità Operativa di Gastroenterologia, Di.Bi.M.I.S., University of Palermo, Palermo, Italy. petsa@inwind.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19223251

Citation

Petta, S, et al. "Non-alcoholic Fatty Liver Disease Pathogenesis: the Present and the Future." Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 41, no. 9, 2009, pp. 615-25.
Petta S, Muratore C, Craxì A. Non-alcoholic fatty liver disease pathogenesis: the present and the future. Dig Liver Dis. 2009;41(9):615-25.
Petta, S., Muratore, C., & Craxì, A. (2009). Non-alcoholic fatty liver disease pathogenesis: the present and the future. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 41(9), 615-25. https://doi.org/10.1016/j.dld.2009.01.004
Petta S, Muratore C, Craxì A. Non-alcoholic Fatty Liver Disease Pathogenesis: the Present and the Future. Dig Liver Dis. 2009;41(9):615-25. PubMed PMID: 19223251.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-alcoholic fatty liver disease pathogenesis: the present and the future. AU - Petta,S, AU - Muratore,C, AU - Craxì,A, Y1 - 2009/02/14/ PY - 2008/09/30/received PY - 2008/12/31/revised PY - 2009/01/08/accepted PY - 2009/2/19/entrez PY - 2009/2/19/pubmed PY - 2009/12/16/medline SP - 615 EP - 25 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 41 IS - 9 N2 - Non-alcoholic fatty liver disease is the clinical hepatic expression of metabolic syndrome. The prevalence of non-alcoholic fatty liver disease is around 20-30%, and with a rapid increase in the metabolic risk factors in the general population, non-alcoholic fatty liver disease has become the most common cause of liver disease worldwide. A fraction (20-30%) of non-alcoholic fatty liver disease patients develop a potentially progressive hepatic disorder, namely non-alcoholic steatohepatitis, leading to end-stage liver disease. The pathogenesis of non-alcoholic fatty liver disease is not entirely understood, and even if insulin resistance is a major pathogenetic key, many other factors are implicated in both liver fat accumulation and disease progression to non-alcoholic steatohepatitis. In this review we aim to examine the literature, principally concerning human non-alcoholic fatty liver disease pathogenesis, and to identify the newest, most promising clinical and basic research data. SN - 1878-3562 UR - https://www.unboundmedicine.com/medline/citation/19223251/Non_alcoholic_fatty_liver_disease_pathogenesis:_the_present_and_the_future_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1590-8658(09)00006-1 DB - PRIME DP - Unbound Medicine ER -